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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Becker, Sidney ; Feldmann, Jonas ; Wiedemann, Stefan ; Okamura, Hidenori ; Schneider, Christina ; Iwan, Katharina ; Crisp, Antony ; Rossa, Martin ; Amatov, Tynchtyk ; Carell, Thomas

Science (American Association for the Advancement of Science), 2019-10, Vol.366 (6461), p.76-82 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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2
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, Jeffrey M ; Medina, Jesús R ; Feng, Yanhong ; Shu, Arthur ; Romeril, Stuart P ; Grant, Seth W ; Li, William Hoi Hong ; Heerding, Dirk A ; Minthorn, Elisabeth ; Mencken, Thomas ; Atkins, Charity ; Liu, Qi ; Rabindran, Sridhar ; Kumar, Rakesh ; Hong, Xuan ; Goetz, Aaron ; Stanley, Thomas ; Taylor, J. David ; Sigethy, Scott D ; Tomberlin, Ginger H ; Hassell, Annie M ; Kahler, Kirsten M ; Shewchuk, Lisa M ; Gampe, Robert T

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7193-7207 [Periódico revisado por pares]

United States: American Chemical Society

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3
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; LaBonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; LaMarche, Matthew J

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7773-7782 [Periódico revisado por pares]

United States: American Chemical Society

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4
Synthetic Entries to and Biological Activity of Pyrrolopyrimidines
Synthetic Entries to and Biological Activity of Pyrrolopyrimidines
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Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

De Coen, Laurens M ; Heugebaert, Thomas S. A ; García, Daniel ; Stevens, Christian V

Chemical reviews, 2016-01, Vol.116 (1), p.80-139 [Periódico revisado por pares]

United States: American Chemical Society

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5
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Marsilje, Thomas H ; Pei, Wei ; Chen, Bei ; Lu, Wenshuo ; Uno, Tetsuo ; Jin, Yunho ; Jiang, Tao ; Kim, Sungjoon ; Li, Nanxin ; Warmuth, Markus ; Sarkisova, Yelena ; Sun, Frank ; Steffy, Auzon ; Pferdekamper, AnneMarie C ; Li, Allen G ; Joseph, Sean B ; Kim, Young ; Liu, Bo ; Tuntland, Tove ; Cui, Xiaoming ; Gray, Nathanael S ; Steensma, Ruo ; Wan, Yongqin ; Jiang, Jiqing ; Chopiuk, Greg ; Li, Jie ; Gordon, W. Perry ; Richmond, Wendy ; Johnson, Kevin ; Chang, Jonathan ; Groessl, Todd ; He, You-Qun ; Phimister, Andrew ; Aycinena, Alex ; Lee, Christian C ; Bursulaya, Badry ; Karanewsky, Donald S ; Seidel, H. Martin ; Harris, Jennifer L ; Michellys, Pierre-Yves

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690 [Periódico revisado por pares]

United States: American Chemical Society

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6
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Turnbull, Andrew P ; Ioannidis, Stephanos ; Krajewski, Wojciech W ; Pinto-Fernandez, Adan ; Heride, Claire ; Martin, Agnes C L ; Tonkin, Louise M ; Townsend, Elizabeth C ; Buker, Shane M ; Lancia, David R ; Caravella, Justin A ; Toms, Angela V ; Charlton, Thomas M ; Lahdenranta, Johanna ; Wilker, Erik ; Follows, Bruce C ; Evans, Nicola J ; Stead, Lucy ; Alli, Cristina ; Zarayskiy, Vladislav V ; Talbot, Adam C ; Buckmelter, Alexandre J ; Wang, Minghua ; McKinnon, Crystal L ; Saab, Fabienne ; McGouran, Joanna F ; Century, Hannah ; Gersch, Malte ; Pittman, Marc S ; Marshall, C Gary ; Raynham, Tony M ; Simcox, Mary ; Stewart, Lorna M D ; McLoughlin, Sheila B ; Escobedo, Jaime A ; Bair, Kenneth W ; Dinsmore, Christopher J ; Hammonds, Tim R ; Kim, Sunkyu ; Urbé, Sylvie ; Clague, Michael J ; Kessler, Benedikt M ; Komander, David

Nature (London), 2017-10, Vol.550 (7677), p.481-486 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
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Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

Sutherland, John D ; Powner, Matthew W ; Gerland, Béatrice

Nature, 2009-05, Vol.459 (7244), p.239-242 [Periódico revisado por pares]

London: Nature Publishing Group

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8
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
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Artigo 		Adicionar ao Meu Espaço

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Guagnano, Vito ; Furet, Pascal ; Spanka, Carsten ; Bordas, Vincent ; Le Douget, Mickaël ; Stamm, Christelle ; Brueggen, Josef ; Jensen, Michael R ; Schnell, Christian ; Schmid, Herbert ; Wartmann, Markus ; Berghausen, Joerg ; Drueckes, Peter ; Zimmerlin, Alfred ; Bussiere, Dirksen ; Murray, Jeremy ; Graus Porta, Diana

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7066-7083 [Periódico revisado por pares]

United States: American Chemical Society

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9
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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Development of a potent and selective chemical probe for the pleiotropic kinase CK2

Wells, Carrow I. ; Drewry, David H. ; Pickett, Julie E. ; Tjaden, Amelie ; Krämer, Andreas ; Müller, Susanne ; Gyenis, Laszlo ; Menyhart, Daniel ; Litchfield, David W. ; Knapp, Stefan ; Axtman, Alison D.

Cell chemical biology, 2021-04, Vol.28 (4), p.546-558.e10 [Periódico revisado por pares]

United States: Elsevier Ltd

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10
Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates
Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates
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Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H Substrates

Hull, Kami L ; Sanford, Melanie S

Journal of the American Chemical Society, 2007-10, Vol.129 (39), p.11904-11905 [Periódico revisado por pares]

United States: American Chemical Society

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