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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Arias-Gómez, Andres ; Godoy, Andrés ; Portilla, Jaime

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2708 [Periódico revisado por pares]

Switzerland: MDPI AG

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2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, Katherine ; Karpiak, Joel ; Liu, Jing ; Huang, Xi-Ping ; McCorvy, John D ; Kroeze, Wesley K ; Che, Tao ; Nagase, Hiroshi ; Carroll, Frank I ; Jin, Jian ; Shoichet, Brian K ; Roth, Bryan L

Nature chemical biology, 2017-05, Vol.13 (5), p.529-536 [Periódico revisado por pares]

United States: Nature Publishing Group

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3
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Zhang, Tinghu ; Kwiatkowski, Nicholas ; Olson, Calla M ; Dixon-Clarke, Sarah E ; Abraham, Brian J ; Greifenberg, Ann K ; Ficarro, Scott B ; Elkins, Jonathan M ; Liang, Yanke ; Hannett, Nancy M ; Manz, Theresa ; Hao, Mingfeng ; Bartkowiak, Bartlomiej ; Greenleaf, Arno L ; Marto, Jarrod A ; Geyer, Matthias ; Bullock, Alex N ; Young, Richard A ; Gray, Nathanael S

Nature chemical biology, 2016-10, Vol.12 (10), p.876-884 [Periódico revisado por pares]

United States: Nature Publishing Group

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4
Biocatalysis in drug discovery and development
Biocatalysis in drug discovery and development
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Biocatalysis in drug discovery and development

Fryszkowska, Anna ; Devine, Paul N.

Current opinion in chemical biology, 2020-04, Vol.55, p.151-160 [Periódico revisado por pares]

England: Elsevier Ltd

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5
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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Development of a potent and selective chemical probe for the pleiotropic kinase CK2

Wells, Carrow I. ; Drewry, David H. ; Pickett, Julie E. ; Tjaden, Amelie ; Krämer, Andreas ; Müller, Susanne ; Gyenis, Laszlo ; Menyhart, Daniel ; Litchfield, David W. ; Knapp, Stefan ; Axtman, Alison D.

Cell chemical biology, 2021-04, Vol.28 (4), p.546-558.e10 [Periódico revisado por pares]

United States: Elsevier Ltd

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6
New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies
New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies
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New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies

Othman, Ismail M.M. ; Alamshany, Zahra M. ; Tashkandi, Nada Y. ; Gad-Elkareem, Mohamed A.M. ; Anwar, Manal M. ; Nossier, Eman S.

Bioorganic chemistry, 2021-09, Vol.114, p.105078, Article 105078 [Periódico revisado por pares]

United States: Elsevier Inc

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7
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
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Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

Ali, Eslam M.H. ; Abdel-Maksoud, Mohammed S. ; Oh, Chang-Hyun

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1159-1194 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Triazolopyrimidine Derivatives: An Updated Review on Recent Advances in Synthesis, Biological Activities and Drug Delivery Aspects
Triazolopyrimidine Derivatives: An Updated Review on Recent Advances in Synthesis, Biological Activities and Drug Delivery Aspects
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Triazolopyrimidine Derivatives: An Updated Review on Recent Advances in Synthesis, Biological Activities and Drug Delivery Aspects

Abdelkhalek, Ahmed S ; Attia, Mohamed S ; Kamal, Mohammad A

Current medicinal chemistry, 2024, Vol.31 (14), p.1896-1919 [Periódico revisado por pares]

United Arab Emirates: Bentham Science Publishers

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9
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
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Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines

Monier, M. ; El-Mekabaty, Ahmed ; Abdel-Latif, Doaa ; Doğru Mert, Başak ; Elattar, Khaled M.

Steroids, 2020-02, Vol.154, p.108548-108548, Article 108548 [Periódico revisado por pares]

United States: Elsevier Inc

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10
Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities
Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities
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Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

Garibov, Emin ; Taslimi, Parham ; Sujayev, Afsun ; Bingol, Zeynebe ; Çetinkaya, Songul ; Gulçin, İlhami ; Beydemir, Sukru ; Farzaliyev, Vagif ; Alwasel, Saleh H. ; Supuran, Claudiu T.

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (sup3), p.1-9 [Periódico revisado por pares]

England: Taylor & Francis

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