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In silico design of novel probes for the atypical opioid receptor MRGPRX2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, Katherine ; Karpiak, Joel ; Liu, Jing ; Huang, Xi-Ping ; McCorvy, John D ; Kroeze, Wesley K ; Che, Tao ; Nagase, Hiroshi ; Carroll, Frank I ; Jin, Jian ; Shoichet, Brian K ; Roth, Bryan L

Nature chemical biology, 2017-05, Vol.13 (5), p.529-536 [Periódico revisado por pares]

United States: Nature Publishing Group

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2
Rhodium(III)-Catalyzed Imidoyl C–H Activation for Annulations to Azolopyrimidines
Rhodium(III)-Catalyzed Imidoyl C–H Activation for Annulations to Azolopyrimidines
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Rhodium(III)-Catalyzed Imidoyl C–H Activation for Annulations to Azolopyrimidines

Halskov, Kim Søholm ; Witten, Michael R ; Hoang, Gia L ; Mercado, Brandon Q ; Ellman, Jonathan A

Organic letters, 2018-04, Vol.20 (8), p.2464-2467 [Periódico revisado por pares]

United States: American Chemical Society

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3
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

Mackman, Richard L ; Mish, Michael ; Chin, Gregory ; Perry, Jason K ; Appleby, Todd ; Aktoudianakis, Vangelis ; Metobo, Sammy ; Pyun, Peter ; Niu, Congrong ; Daffis, Stephane ; Yu, Helen ; Zheng, Jim ; Villasenor, Armando G ; Zablocki, Jeff ; Chamberlain, Jason ; Jin, Haolun ; Lee, Gary ; Suekawa-Pirrone, Kimberley ; Santos, Rex ; Delaney, William E ; Fletcher, Simon P

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10188-10203 [Periódico revisado por pares]

United States: American Chemical Society

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4
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Dilger, Andrew K ; Pabbisetty, Kumar B ; Corte, James R ; De Lucca, Indawati ; Fang, Tianan ; Yang, Wu ; Pinto, Donald J. P ; Wang, Yufeng ; Zhu, Yeheng ; Mathur, Arvind ; Li, Jianqing ; Hou, Xiaoping ; Smith, Daniel ; Sun, Dawn ; Zhang, Huiping ; Krishnananthan, Subramaniam ; Wu, Dauh-Rurng ; Myers, Joseph E ; Sheriff, Steven ; Rossi, Karen A ; Chacko, Silvi ; Zheng, Joanna J ; Galella, Michael A ; Ziemba, Theresa ; Dierks, Elizabeth A ; Bozarth, Jeffrey M ; Wu, Yiming ; Crain, Earl ; Wong, Pancras C ; Luettgen, Joseph M ; Wexler, Ruth R ; Ewing, William R

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1770-1785 [Periódico revisado por pares]

United States: American Chemical Society

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5
Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
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Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

Madhu Sekhar, M. ; Nagarjuna, U. ; Padmavathi, V. ; Padmaja, A. ; Reddy, N. Vasudeva ; Vijaya, T.

European journal of medicinal chemistry, 2018-02, Vol.145, p.1-10 [Periódico revisado por pares]

France: Elsevier Masson SAS

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6
Identification of Dihydrofuro[3,4‑d]pyrimidine Derivatives as Novel HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
Identification of Dihydrofuro[3,4‑d]pyrimidine Derivatives as Novel HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
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Identification of Dihydrofuro[3,4‑d]pyrimidine Derivatives as Novel HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

Kang, Dongwei ; Zhang, Heng ; Wang, Zhao ; Zhao, Tong ; Ginex, Tiziana ; Luque, Francisco Javier ; Yang, Yang ; Wu, Gaochan ; Feng, Da ; Wei, Fenju ; Zhang, Jian ; De Clercq, Erik ; Pannecouque, Christophe ; Chen, Chin Ho ; Lee, Kuo-Hsiung ; Murugan, N. Arul ; Steitz, Thomas A ; Zhan, Peng ; Liu, Xinyong

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1484-1501 [Periódico revisado por pares]

United States: American Chemical Society

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7
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
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Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine

Kopina, Brett J ; Lauhon, Charles T

Organic letters, 2012-08, Vol.14 (16), p.4118-4121 [Periódico revisado por pares]

United States: American Chemical Society

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8
Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation
Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation
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Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation

Liu, Han-Bo ; Gao, Wei-Wei ; Tangadanchu, Vijai Kumar Reddy ; Zhou, Cheng-He ; Geng, Rong-Xia

European journal of medicinal chemistry, 2018-01, Vol.143, p.66-84 [Periódico revisado por pares]

France: Elsevier Masson SAS

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9
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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Development of a potent and selective chemical probe for the pleiotropic kinase CK2

Wells, Carrow I. ; Drewry, David H. ; Pickett, Julie E. ; Tjaden, Amelie ; Krämer, Andreas ; Müller, Susanne ; Gyenis, Laszlo ; Menyhart, Daniel ; Litchfield, David W. ; Knapp, Stefan ; Axtman, Alison D.

Cell chemical biology, 2021-04, Vol.28 (4), p.546-558.e10 [Periódico revisado por pares]

United States: Elsevier Ltd

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10
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase
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Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase

Kumar, Bhupinder ; Kumar, Vijay ; Prashar, Vikash ; Saini, Suresh ; Dwivedi, Ashish Ranjan ; Bajaj, Beenu ; Mehta, Devashish ; Parkash, Jyoti ; Kumar, Vinod

European journal of medicinal chemistry, 2019-09, Vol.177, p.221-234 [Periódico revisado por pares]

France: Elsevier Masson SAS

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