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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Hyer, Marc L ; Milhollen, Michael A ; Ciavarri, Jeff ; Fleming, Paul ; Traore, Tary ; Sappal, Darshan ; Huck, Jessica ; Shi, Judy ; Gavin, James ; Brownell, Jim ; Yang, Yu ; Stringer, Bradley ; Griffin, Robert ; Bruzzese, Frank ; Soucy, Teresa ; Duffy, Jennifer ; Rabino, Claudia ; Riceberg, Jessica ; Hoar, Kara ; Lublinsky, Anya ; Menon, Saurabh ; Sintchak, Michael ; Bump, Nancy ; Pulukuri, Sai M ; Langston, Steve ; Tirrell, Stephen ; Kuranda, Mike ; Veiby, Petter ; Newcomb, John ; Li, Ping ; Wu, Jing Tao ; Powe, Josh ; Dick, Lawrence R ; Greenspan, Paul ; Galvin, Katherine ; Manfredi, Mark ; Claiborne, Chris ; Amidon, Benjamin S ; Bence, Neil F

Nature medicine, 2018-02, Vol.24 (2), p.186-193 [Periódico revisado por pares]

United States: Nature Publishing Group

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2
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Shin, Donghyuk ; Mukherjee, Rukmini ; Grewe, Diana ; Bojkova, Denisa ; Baek, Kheewoong ; Bhattacharya, Anshu ; Schulz, Laura ; Widera, Marek ; Mehdipour, Ahmad Reza ; Tascher, Georg ; Geurink, Paul P ; Wilhelm, Alexander ; van der Heden van Noort, Gerbrand J ; Ovaa, Huib ; Müller, Stefan ; Knobeloch, Klaus-Peter ; Rajalingam, Krishnaraj ; Schulman, Brenda A ; Cinatl, Jindrich ; Hummer, Gerhard ; Ciesek, Sandra ; Dikic, Ivan

Nature (London), 2020-11, Vol.587 (7835), p.657-662 [Periódico revisado por pares]

England: Nature Publishing Group

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3
COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence?
COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence?
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COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence?

Patel, Ankit B ; Verma, Ashish

JAMA : the journal of the American Medical Association, 2020-05, Vol.323 (18), p.1769 [Periódico revisado por pares]

United States: American Medical Association

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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove, Hannah ; Martens, Liesbet ; Scheyltjens, Isabelle ; De Vlaminck, Karen ; Pombo Antunes, Ana Rita ; De Prijck, Sofie ; Vandamme, Niels ; De Schepper, Sebastiaan ; Van Isterdael, Gert ; Scott, Charlotte L ; Aerts, Jeroen ; Berx, Geert ; Boeckxstaens, Guy E ; Vandenbroucke, Roosmarijn E ; Vereecke, Lars ; Moechars, Diederik ; Guilliams, Martin ; Van Ginderachter, Jo A ; Saeys, Yvan ; Movahedi, Kiavash

Nature neuroscience, 2019-06, Vol.22 (6), p.1021-1035 [Periódico revisado por pares]

United States: Nature Publishing Group

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5
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Huber, Kilian V M ; Salah, Eidarus ; Radic, Branka ; Gridling, Manuela ; Elkins, Jonathan M ; Stukalov, Alexey ; Jemth, Ann-Sofie ; Göktürk, Camilla ; Sanjiv, Kumar ; Strömberg, Kia ; Pham, Therese ; Berglund, Ulrika Warpman ; Colinge, Jacques ; Bennett, Keiryn L ; Loizou, Joanna I ; Helleday, Thomas ; Knapp, Stefan ; Superti-Furga, Giulio

Nature (London), 2014-04, Vol.508 (7495), p.222-227 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Lysosomes as a therapeutic target
Lysosomes as a therapeutic target
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Lysosomes as a therapeutic target

Bonam, Srinivasa Reddy ; Wang, Fengjuan ; Muller, Sylviane

Nature reviews. Drug discovery, 2019-12, Vol.18 (12), p.923-948 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Yankova, Eliza ; Blackaby, Wesley ; Albertella, Mark ; Rak, Justyna ; De Braekeleer, Etienne ; Tsagkogeorga, Georgia ; Pilka, Ewa S ; Aspris, Demetrios ; Leggate, Dan ; Hendrick, Alan G ; Webster, Natalie A ; Andrews, Byron ; Fosbeary, Richard ; Guest, Patrick ; Irigoyen, Nerea ; Eleftheriou, Maria ; Gozdecka, Malgorzata ; Dias, Joao M L ; Bannister, Andrew J ; Vick, Binje ; Jeremias, Irmela ; Vassiliou, George S ; Rausch, Oliver ; Tzelepis, Konstantinos ; Kouzarides, Tony

Nature (London), 2021-05, Vol.593 (7860), p.597-601 [Periódico revisado por pares]

England: Nature Publishing Group

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8
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D Allan ; Halliwell, Barry

Nature reviews. Neuroscience, 2019-03, Vol.20 (3), p.148-160 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
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Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Forman, Henry Jay ; Zhang, Hongqiao

Nature reviews. Drug discovery, 2021-09, Vol.20 (9), p.689-709 [Periódico revisado por pares]

England: Nature Publishing Group

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10
Feedback control of AHR signalling regulates intestinal immunity
Feedback control of AHR signalling regulates intestinal immunity
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Feedback control of AHR signalling regulates intestinal immunity

Schiering, Chris ; Wincent, Emma ; Metidji, Amina ; Iseppon, Andrea ; Li, Ying ; Potocnik, Alexandre J ; Omenetti, Sara ; Henderson, Colin J ; Wolf, C Roland ; Nebert, Daniel W ; Stockinger, Brigitta

Nature (London), 2017-02, Vol.542 (7640), p.242-245 [Periódico revisado por pares]

England: Nature Publishing Group

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