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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

Hall, Justin ; Brault, Amy ; Vincent, Fabien ; Weng, Shawn ; Wang, Hong ; Dumlao, Darren ; Aulabaugh, Ann ; Aivazian, Dikran ; Castro, Dana ; Chen, Ming ; Culp, Jeffrey ; Dower, Ken ; Gardner, Joseph ; Hawrylik, Steven ; Golenbock, Douglas ; Hepworth, David ; Horn, Mark ; Jones, Lyn ; Jones, Peter ; Latz, Eicke ; Li, Jing ; Lin, Lih-Ling ; Lin, Wen ; Lin, David ; Lovering, Frank ; Niljanskul, Nootaree ; Nistler, Ryan ; Pierce, Betsy ; Plotnikova, Olga ; Schmitt, Daniel ; Shanker, Suman ; Smith, James ; Snyder, William ; Subashi, Timothy ; Trujillo, John ; Tyminski, Edyta ; Wang, Guoxing ; Wong, Jimson ; Lefker, Bruce ; Dakin, Leslie ; Leach, Karen Nakano, Hiroyasu

PloS one, 2017-09, Vol.12 (9), p.e0184843-e0184843 [Periódico revisado por pares]

United States: Public Library of Science

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2
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice
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Treatment of a metabolic liver disease by in vivo genome base editing in adult mice

Villiger, Lukas ; Grisch-Chan, Hiu Man ; Lindsay, Helen ; Ringnalda, Femke ; Pogliano, Chiara B ; Allegri, Gabriella ; Fingerhut, Ralph ; Häberle, Johannes ; Matos, Joao ; Robinson, Mark D ; Thöny, Beat ; Schwank, Gerald

Nature medicine, 2018-10, Vol.24 (10), p.1519-1525 [Periódico revisado por pares]

United States: Nature Publishing Group

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3
Comparative genomics of the major parasitic worms
Comparative genomics of the major parasitic worms
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Comparative genomics of the major parasitic worms

Coghlan, Avril ; Tyagi, Rahul ; Cotton, James A ; Holroyd, Nancy ; Rosa, Bruce A ; Tsai, Isheng Jason ; Laetsch, Dominik R ; Beech, Robin N ; Day, Tim A ; Hallsworth-Pepin, Kymberlie ; Ke, Huei-Mien ; Kuo, Tzu-Hao ; Lee, Tracy J ; Martin, John ; Maizels, Rick M ; Mutowo, Prudence ; Ozersky, Philip ; Parkinson, John ; Reid, Adam J ; Rawlings, Neil D ; Ribeiro, Diogo M ; Swapna, Lakshmipuram Seshadri ; Stanley, Eleanor ; Taylor, David W ; Wheeler, Nicolas J ; Zamanian, Mostafa ; Zhang, Xu ; Allan, Fiona ; Allen, Judith E ; Asano, Kazuhito ; Babayan, Simon A ; Bah, Germanus ; Beasley, Helen ; Bennett, Hayley M ; Bisset, Stewart A ; Castillo, Estela ; Cook, Joseph ; Cooper, Philip J ; Cruz-Bustos, Teresa ; Cuéllar, Carmen ; Devaney, Eileen ; Doyle, Stephen R ; Eberhard, Mark L ; Emery, Aidan ; Eom, Keeseon S ; Gilleard, John S ; Gordon, Daria ; Harcus, Yvonne ; Harsha, Bhavana ; Hawdon, John M ; Hill, Dolores E ; Hodgkinson, Jane ; Horák, Petr ; Howe, Kevin L ; Huckvale, Thomas ; Kalbe, Martin ; Kaur, Gaganjot ; Kikuchi, Taisei ; Koutsovoulos, Georgios ; Kumar, Sujai ; Leach, Andrew R ; Lomax, Jane ; Makepeace, Benjamin ; Matthews, Jacqueline B ; Muro, Antonio ; O'Boyle, Noel Michael ; Olson, Peter D ; Osuna, Antonio ; Partono, Felix ; Pfarr, Kenneth ; Rinaldi, Gabriel ; onda, Pilar ; Rollinson, David ; Samblas, Mercedes Gomez ; Sato, Hiroshi ; Schnyder, Manuela ; Scholz, Tomáš ; Shafie, Myriam ; Tanya, Vincent N ; Toledo, Rafael ; Tracey, Alan ; Urban, Joseph F ; Wang, Lian-Chen ; Zarlenga, Dante ; Blaxter, Mark L ; Mitreva, Makedonka ; Berriman, Matthew

Nature genetics, 2019-01, Vol.51 (1), p.163-174 [Periódico revisado por pares]

United States: Nature Publishing Group

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4
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
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Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

Ansari, Aneesa ; Rahman, Md. Shahedur ; Saha, Subbroto K. ; Saikot, Forhad K. ; Deep, Akash ; Kim, Ki‐Hyun

Aging cell, 2017-02, Vol.16 (1), p.4-16 [Periódico revisado por pares]

England: John Wiley & Sons, Inc

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5
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
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Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

Merke, Deborah P ; Auchus, Richard J Ingelfinger, Julie R ; Ingelfinger, Julie R.

The New England journal of medicine, 2020-09, Vol.383 (13), p.1248-1261 [Periódico revisado por pares]

Boston: Massachusetts Medical Society

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6
Metalloproteinases and their natural inhibitors in inflammation and immunity
Metalloproteinases and their natural inhibitors in inflammation and immunity
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Metalloproteinases and their natural inhibitors in inflammation and immunity

Khokha, Rama ; Murthy, Aditya ; Weiss, Ashley

Nature reviews. Immunology, 2013-09, Vol.13 (9), p.649-665 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Systems-Level Analysis of Nitrogen Starvation—Induced Modifications of Carbon Metabolism in a Chlamydomonas reinhardtii Starchless Mutant
Systems-Level Analysis of Nitrogen Starvation—Induced Modifications of Carbon Metabolism in a Chlamydomonas reinhardtii Starchless Mutant
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Systems-Level Analysis of Nitrogen Starvation—Induced Modifications of Carbon Metabolism in a Chlamydomonas reinhardtii Starchless Mutant

Blaby, Ian K. ; Glaesener, Anne G. ; Mettler, Tabea ; Gibbon, Sorel T. Fitz ; Gallaher, Sean D. ; Liu, Bensheng ; Boyle, Nanette R. ; Kropat, Janette ; Stitt, Mark ; Johnson, Shannon ; Benning, Christoph ; Pellegrini, Matteo ; Casero, David ; Merchant, Sabeeha S.

The Plant cell, 2013-11, Vol.25 (11), p.4305-4323 [Periódico revisado por pares]

United States: American Society of Plant Biologists

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8
Histone lactylation links metabolism and gene regulation
Histone lactylation links metabolism and gene regulation
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Histone lactylation links metabolism and gene regulation

Izzo, Luke T ; Wellen, Kathryn E

Nature (London), 2019-10, Vol.574 (7779), p.492-493 [Periódico revisado por pares]

Nature Publishing Group

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9
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Musunuru, Kiran ; Chadwick, Alexandra C ; Mizoguchi, Taiji ; Garcia, Sara P ; DeNizio, Jamie E ; Reiss, Caroline W ; Wang, Kui ; Iyer, Sowmya ; Dutta, Chaitali ; Clendaniel, Victoria ; Amaonye, Michael ; Beach, Aaron ; Berth, Kathleen ; Biswas, Souvik ; Braun, Maurine C ; Chen, Huei-Mei ; Colace, Thomas V ; Ganey, John D ; Gangopadhyay, Soumyashree A ; Garrity, Ryan ; Kasiewicz, Lisa N ; Lavoie, Jennifer ; Madsen, James A ; Matsumoto, Yuri ; Mazzola, Anne Marie ; Nasrullah, Yusuf S ; Nneji, Joseph ; Ren, Huilan ; Sanjeev, Athul ; Shay, Madeleine ; Stahley, Mary R ; Fan, Steven H Y ; Tam, Ying K ; Gaudelli, Nicole M ; Ciaramella, Giuseppe ; Stolz, Leslie E ; Malyala, Padma ; Cheng, Christopher J ; Rajeev, Kallanthottathil G ; Rohde, Ellen ; Bellinger, Andrew M ; Kathiresan, Sekar

Nature (London), 2021-05, Vol.593 (7859), p.429-434 [Periódico revisado por pares]

England: Nature Publishing Group

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10
Complex roles of cAMP–PKA–CREB signaling in cancer
Complex roles of cAMP–PKA–CREB signaling in cancer
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Complex roles of cAMP–PKA–CREB signaling in cancer

Zhang, Hongying ; Kong, Qingbin ; Wang, Jiao ; Jiang, Yangfu ; Hua, Hui

Experimental hematology & oncology, 2020-11, Vol.9 (1), p.1-32, Article 32 [Periódico revisado por pares]

London: BioMed Central Ltd

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