Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma

Mastrella, Giorgia ; Hou, Mengzhuo ; Li, Min ; Stoecklein, Veit M ; Zdouc, Nina ; Volmar, Marie N M ; Miletic, Hrvoje ; Reinhard, Sören ; Herold-Mende, Christel C ; Kleber, Susanne ; Eisenhut, Katharina ; Gargiulo, Gaetano ; Synowitz, Michael ; Vescovi, Angelo L ; Harter, Patrick N ; Penninger, Josef M ; Wagner, Ernst ; Mittelbronn, Michel ; Bjerkvig, Rolf ; Hambardzumyan, Dolores ; Schüller, Ulrich ; Tonn, Jörg-Christian ; Radke, Josefine ; Glass, Rainer ; Kälin, Roland E

United States

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SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

MICHELS, Sebastian ; TRAUTMANN, Marcel ; WURST, Peter ; HEUKAMP, Lukas ; PENZEL, Roland ; LARSSON, Olle ; KAWAI, Akira ; TANAKA, Shinya ; SONOBE, Hiroshi ; SCHIRMACHER, Peter ; MECHTERSHEIMER, Gunhild ; WARDELMANN, Eva ; SIEVERS, Elisabeth ; BÜTTNER, Reinhard ; HARTMANN, Wolfgang ; KINDLER, Dagmar ; HUSS, Sebastian ; RENNER, Marcus ; FRIEDRICHS, Nicolaus ; KIRFEL, Jutta ; STEINER, Susanne ; ENDL, Elmar

Philadelphia, PA: American Association for Cancer Research

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Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis

ROLFS, Frank ; HUBER, Marcel ; WERNER, Sabine ; GRUBER, Florian ; BÖHM, Friederike ; PFISTER, Herbert J ; BOCHKOV, Valery N ; TSCHACHLER, Erwin ; DUMMER, Reinhard ; HOHL, Daniel ; SCHÄFER, Matthias

Philadelphia, PA: American Association for Cancer Research

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Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro

Aryee, Dave N T ; Niedan, Stephan ; Kauer, Maximilian ; Schwentner, Raphaela ; Bennani-Baiti, Idriss M ; Ban, Jozef ; Muehlbacher, Karin ; Kreppel, Michael ; Walker, Robert L ; Meltzer, Paul ; Poremba, Christopher ; Kofler, Reinhard ; Kovar, Heinrich

United States

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Abstract 2125: Genetic analysis for classification and treatment of poorly differentiated sinonasal cancer

Hermsen, Mario ; Riobello, Cristina ; Cabal, Virginia N. ; García-Marín, Rocío ; Potes-Ares, Sira ; Suárez-Fernández, Laura ; Vivanco, Blanca ; Franchi, Alessandro ; Büttner, Reinhard ; López, Fernando ; Llorente, José Luis

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Abstract 2161: Identifying GDF-15 as potential novel immunotherapeutic target linked to immune cell exclusion in tumors and resistance to anti-PD-1 treatment

Wischhusen, Jorg ; Wistuba-Hamprecht, Kilian ; Harter, Patrick N. ; Cheng, Phil ; Martens, Alexander ; Gogolla, Falk ; Nonomura, Yumi ; Romer, Paula ; Koch, Sven D. ; Haake, Markus ; Schuberth-Wagner, Christine ; Rudiger, Manfred ; Leo, Eugen ; Mittelbronn, Michael ; Levesque, Mitchell P. ; Hackl, Hubert ; Dummer, Reinhard ; Weide, Benjamin

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Tumor susceptibility of Rassf1a knockout mice

Tommasi, Stella ; Dammann, Reinhard ; Zhang, Zhongqiu ; Wang, Yian ; Liu, Limin ; Tsark, Walter M ; Wilczynski, Sharon P ; Li, Jie ; You, Ming ; Pfeifer, Gerd P

United States

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Abstract CT002: Phase 3 randomized trial comparing tebentafusp with investigator's choice in first line metastatic uveal melanoma

Piperno-Neumann, Sophie ; Hassel, Jessica C. ; Rutkowski, Piotr ; Baurain, Jean-Francois ; Butler, Marcus O. ; Schlaak, Max ; Sullivan, Ryan J. ; Ochsenreither, Sebastian ; Dummer, Reinhard ; Kirkwood, John M. ; Joshua, Anthony M. ; Sacco, Joseph J. ; Shoushtari, Alexander N. ; Orloff, Marlana ; Carvajal, Richard D. ; Hamid, Omid ; Abdullah, Shaad E. ; Holland, Chris ; Goodall, Howard ; Nathan, Paul

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Abstract CT255: EATON: A phase I dose-escalation trial of nazartinib (EGF816) and trametinib in EGFR-mutant NSCLC

Michels, Sebastian ; Nogova, Lucia ; Scheffler, Matthias ; Deschler-Baier, Barbara ; Sebastian, Martin ; Schuler, Martin ; Wermke, Martin ; Felip, Enriqueta ; Rosell, Rafael ; Abreu, Delvys Rodriguez ; Abdulla, Diana S.Y. ; Fischer, Rieke N. ; Koleczko, Sophia ; Kron, Anna ; Riedel, Richard ; Weber, Jan-Philipp ; Fassunke, Jana ; Merkelbach-Bruse, Sabine ; Haverkammp, Heinz ; Hellmich, Martin ; Büttner, Reinhard ; Wolf, Jürgen

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Abstract 2304: In vivo E2F reporting reveals efficacious schedules of MEK1/2-CDK4/6 targeting and mTOR-S6 resistance mechanisms

Teh, Jessica ; Cheng, Phil F. ; Purwin, Timothy J. ; Nikbakht, Neda ; Patel, Prem ; Chervoneva, Inna ; Keibler, Ines ; Kim, HooKim ; Davies, Michael A. ; Kwong, Lawrence N. ; Levesque, Mitch P. ; Dummer, Reinhard ; Aplin, Andrew E.

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