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Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR)
Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR)
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Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR)

Kumari, Archana ; Singh, Rajesh K.

Bioorganic chemistry, 2020-03, Vol.96, p.103578, Article 103578 [Periódico revisado por pares]

United States: Elsevier Inc

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2
A Lysosome-Targetable and Two-Photon Fluorescent Probe for Monitoring Endogenous and Exogenous Nitric Oxide in Living Cells
A Lysosome-Targetable and Two-Photon Fluorescent Probe for Monitoring Endogenous and Exogenous Nitric Oxide in Living Cells
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A Lysosome-Targetable and Two-Photon Fluorescent Probe for Monitoring Endogenous and Exogenous Nitric Oxide in Living Cells

Yu, Haibo ; Xiao, Yi ; Jin, Liji

Journal of the American Chemical Society, 2012-10, Vol.134 (42), p.17486-17489 [Periódico revisado por pares]

United States: American Chemical Society

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3
Waste disposal—An attractive strategy for cancer therapy
Waste disposal—An attractive strategy for cancer therapy
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Waste disposal—An attractive strategy for cancer therapy

Salami, Jemilat ; Crews, Craig M.

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6330), p.1163-1168 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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4
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Sheng, Xia ; Nenseth, Hatice Zeynep ; Qu, Su ; Kuzu, Omer F ; Frahnow, Turid ; Simon, Lukas ; Greene, Stephanie ; Zeng, Qingping ; Fazli, Ladan ; Rennie, Paul S ; Mills, Ian G ; Danielsen, Håvard ; Theis, Fabian ; Patterson, John B ; Jin, Yang ; Saatcioglu, Fahri

Nature communications, 2019-01, Vol.10 (1), p.323-12, Article 323 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Maira, Sauveur-Michel ; Pecchi, Sabina ; Huang, Alan ; Burger, Matthew ; Knapp, Mark ; Sterker, Dario ; Schnell, Christian ; Guthy, Daniel ; Nagel, Tobi ; Wiesmann, Marion ; Brachmann, Saskia ; Fritsch, Christine ; Dorsch, Marion ; Chène, Patrick ; Shoemaker, Kevin ; De Pover, Alain ; Menezes, Daniel ; Martiny-Baron, Georg ; Fabbro, Doriano ; Wilson, Christopher J ; Schlegel, Robert ; Hofmann, Francesco ; García-Echeverría, Carlos ; Sellers, William R ; Voliva, Charles F

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.317-328 [Periódico revisado por pares]

United States

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6
Synthetic cannabinoids nano-micelles for the management of triple negative breast cancer
Synthetic cannabinoids nano-micelles for the management of triple negative breast cancer
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Synthetic cannabinoids nano-micelles for the management of triple negative breast cancer

Greish, Khaled ; Mathur, Aanchal ; Al Zahrani, Reem ; Elkaissi, Sara ; Al Jishi, Muna ; Nazzal, Osama ; Taha, Safa ; Pittalà, Valeria ; Taurin, Sebastien

Journal of controlled release, 2018-12, Vol.291, p.184-195 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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7
Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)‑N‑((S)‑3-(Cyclopent-1-en-1-yl)-1-((R)‑2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)‑2-(2-morpholinoacetamido)­propanamido)­propenamide)
Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)‑N‑((S)‑3-(Cyclopent-1-en-1-yl)-1-((R)‑2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)‑2-(2-morpholinoacetamido)­propanamido)­propenamide)
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Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)‑N‑((S)‑3-(Cyclopent-1-en-1-yl)-1-((R)‑2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)‑2-(2-morpholinoacetamido)­propanamido)­propenamide)

Johnson, Henry W. B ; Lowe, Eric ; Anderl, Janet L ; Fan, Andrea ; Muchamuel, Tony ; Bowers, Simeon ; Moebius, David C ; Kirk, Christopher ; McMinn, Dustin L

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11127-11143 [Periódico revisado por pares]

United States: American Chemical Society

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8
Pemigatinib: First Approval
Pemigatinib: First Approval
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Pemigatinib: First Approval

Hoy, Sheridan M.

Drugs (New York, N.Y.), 2020-06, Vol.80 (9), p.923-929 [Periódico revisado por pares]

Cham: Springer International Publishing

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9
Polysulfides link H2S to protein thiol oxidation
Polysulfides link H2S to protein thiol oxidation
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Polysulfides link H2S to protein thiol oxidation

Greiner, Romy ; Pálinkás, Zoltán ; Bäsell, Katrin ; Becher, Dörte ; Antelmann, Haike ; Nagy, Péter ; Dick, Tobias P

Antioxidants & redox signaling, 2013-11, Vol.19 (15), p.1749-1765 [Periódico revisado por pares]

United States: Mary Ann Liebert, Inc

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10
PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation
PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation
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PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation

Motawe, Zeinab Y. ; Abdelmaboud, Salma S. ; Cuevas, Javier ; Breslin, Jerome W.

The international journal of biochemistry & cell biology, 2020-09, Vol.126, p.105803-105803, Article 105803 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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