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Refinado por: assunto: Antineoplastic Agents - Pharmacology remover
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1
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Knutson, Sarah K. ; Warholic, Natalie M. ; Wigle, Tim J. ; Klaus, Christine R. ; Allain, Christina J. ; Raimondi, Alejandra ; Scott, Margaret Porter ; Chesworth, Richard ; Moyer, Mikel P. ; Copeland, Robert A. ; Richon, Victoria M. ; Pollock, Roy M. ; Kuntz, Kevin W. ; Keilhack, Heike

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7922-7927 [Periódico revisado por pares]

United States: National Academy of Sciences

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2
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

Knutson, Sarah K ; Kawano, Satoshi ; Minoshima, Yukinori ; Warholic, Natalie M ; Huang, Kuan-Chun ; Xiao, Yonghong ; Kadowaki, Tadashi ; Uesugi, Mai ; Kuznetsov, Galina ; Kumar, Namita ; Wigle, Tim J ; Klaus, Christine R ; Allain, Christina J ; Raimondi, Alejandra ; Waters, Nigel J ; Smith, Jesse J ; Porter-Scott, Margaret ; Chesworth, Richard ; Moyer, Mikel P ; Copeland, Robert A ; Richon, Victoria M ; Uenaka, Toshimitsu ; Pollock, Roy M ; Kuntz, Kevin W ; Yokoi, Akira ; Keilhack, Heike

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.842-854 [Periódico revisado por pares]

United States

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3
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Knutson, Sarah K ; Wigle, Tim J ; Warholic, Natalie M ; Sneeringer, Christopher J ; Allain, Christina J ; Klaus, Christine R ; Sacks, Joelle D ; Raimondi, Alejandra ; Majer, Christina R ; Song, Jeffrey ; Scott, Margaret Porter ; Jin, Lei ; Smith, Jesse J ; Olhava, Edward J ; Chesworth, Richard ; Moyer, Mikel P ; Richon, Victoria M ; Copeland, Robert A ; Keilhack, Heike ; Pollock, Roy M ; Kuntz, Kevin W

Nature chemical biology, 2012-11, Vol.8 (11), p.890-896 [Periódico revisado por pares]

United States: Nature Publishing Group

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4
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Kawano, Satoshi ; Grassian, Alexandra R ; Tsuda, Masumi ; Knutson, Sarah K ; Warholic, Natalie M ; Kuznetsov, Galina ; Xu, Shanqin ; Xiao, Yonghong ; Pollock, Roy M ; Smith, Jesse S ; Kuntz, Kevin K ; Ribich, Scott ; Minoshima, Yukinori ; Matsui, Junji ; Copeland, Robert A ; Tanaka, Shinya ; Keilhack, Heike Rota, Rossella

PloS one, 2016-07, Vol.11 (7), p.e0158888-e0158888 [Periódico revisado por pares]

United States: Public Library of Science

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5
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Daigle, Scott R. ; Olhava, Edward J. ; Therkelsen, Carly A. ; Basavapathruni, Aravind ; Jin, Lei ; Boriack-Sjodin, P. Ann ; Allain, Christina J. ; Klaus, Christine R. ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J. ; Chesworth, Richard ; Moyer, Mikel P. ; Copeland, Robert A. ; Richon, Victoria M. ; Pollock, Roy M.

Blood, 2013-08, Vol.122 (6), p.1017-1025 [Periódico revisado por pares]

United States: Elsevier Inc

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6
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne ; Kuplast, Kristy G ; Majer, Christina R ; Boriack-Sjodin, P Ann ; Wigle, Tim J ; Johnston, L Danielle ; Rioux, Nathalie ; Munchhof, Michael J ; Jin, Lei ; Jacques, Suzanne L ; West, Kip A ; Lingaraj, Trupti ; Stickland, Kimberly ; Ribich, Scott A ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J ; Pollock, Roy M ; Smith, Jesse J ; Barbash, Olena ; Pappalardi, Melissa ; Ho, Thau F ; Nurse, Kelvin ; Oza, Khyati P ; Gallagher, Kathleen T ; Kruger, Ryan ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard ; Duncan, Kenneth W

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437 [Periódico revisado por pares]

United States: Nature Publishing Group

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7
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

Knutson, Sarah K ; Warholic, Natalie M ; Johnston, L Danielle ; Klaus, Christine R ; Wigle, Tim J ; Iwanowicz, Dorothy ; Littlefield, Bruce A ; Porter-Scott, Margaret ; Smith, Jesse J ; Moyer, Mikel P ; Copeland, Robert A ; Pollock, Roy M ; Kuntz, Kevin W ; Raimondi, Alejandra ; Keilhack, Heike Tuckermann, Jan Peter

PloS one, 2014-12, Vol.9 (12), p.e111840 [Periódico revisado por pares]

United States: Public Library of Science

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8
MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition
MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition
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MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Kühn, Michael W M ; Hadler, Michael J ; Daigle, Scott R ; Koche, Richard P ; Krivtsov, Andrei V ; Olhava, Edward J ; Caligiuri, Michael A ; Huang, Gang ; Bradner, James E ; Pollock, Roy M ; Armstrong, Scott A

Haematologica (Roma), 2015-05, Vol.100 (5), p.e190-e193 [Periódico revisado por pares]

Italy: Ferrata Storti Foundation

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9
Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry
Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry
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Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry

Lee, Anita Y. H ; Paweletz, Cloud P ; Pollock, Roy M ; Settlage, Robert E ; Cruz, Jonathan C ; Secrist, J. Paul ; Miller, Thomas A ; Stanton, Matthew G ; Kral, Astrid M ; Ozerova, Nicole D. S ; Meng, Fanyu ; Yates, Nathan A ; Richon, Victoria ; Hendrickson, Ronald C

Journal of proteome research, 2008-12, Vol.7 (12), p.5177-5186 [Periódico revisado por pares]

United States: American Chemical Society

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