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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Canon, Jude ; Rex, Karen ; Saiki, Anne Y ; Mohr, Christopher ; Cooke, Keegan ; Bagal, Dhanashri ; Gaida, Kevin ; Holt, Tyler ; Knutson, Charles G ; Koppada, Neelima ; Lanman, Brian A ; Werner, Jonathan ; Rapaport, Aaron S ; San Miguel, Tisha ; Ortiz, Roberto ; Osgood, Tao ; Sun, Ji-Rong ; Zhu, Xiaochun ; McCarter, John D ; Volak, Laurie P ; Houk, Brett E ; Fakih, Marwan G ; O'Neil, Bert H ; Price, Timothy J ; Falchook, Gerald S ; Desai, Jayesh ; Kuo, James ; Govindan, Ramaswamy ; Hong, David S ; Ouyang, Wenjun ; Henary, Haby ; Arvedson, Tara ; Cee, Victor J ; Lipford, J Russell

Nature (London), 2019-11, Vol.575 (7781), p.217-223 [Periódico revisado por pares]

England: Nature Publishing Group

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12
Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study
Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study
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Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study

Nogova, Lucia ; Sequist, Lecia V ; Perez Garcia, Jose Manuel ; Andre, Fabrice ; Delord, Jean-Pierre ; Hidalgo, Manuel ; Schellens, Jan H M ; Cassier, Philippe A ; Camidge, D Ross ; Schuler, Martin ; Vaishampayan, Ulka ; Burris, Howard ; Tian, G Gary ; Campone, Mario ; Wainberg, Zev A ; Lim, Wan-Teck ; LoRusso, Patricia ; Shapiro, Geoffrey I ; Parker, Katie ; Chen, Xueying ; Choudhury, Somesh ; Ringeisen, Francois ; Graus-Porta, Diana ; Porter, Dale ; Isaacs, Randi ; Buettner, Reinhard ; Wolf, Jürgen

Journal of clinical oncology, 2017-01, Vol.35 (2), p.157-165 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

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13
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Arias-Gómez, Andres ; Godoy, Andrés ; Portilla, Jaime

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2708 [Periódico revisado por pares]

Switzerland: MDPI AG

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14
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
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Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines

Naglah, Ahmed M ; Askar, Ahmed A ; Hassan, Ashraf S ; Khatab, Tamer K ; Al-Omar, Mohamed A ; Bhat, Mashooq A

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1431 [Periódico revisado por pares]

Switzerland: MDPI AG

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15
Risdiplam in Type 1 Spinal Muscular Atrophy
Risdiplam in Type 1 Spinal Muscular Atrophy
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Risdiplam in Type 1 Spinal Muscular Atrophy

Baranello, Giovanni ; Darras, Basil T ; Day, John W ; Deconinck, Nicolas ; Klein, Andrea ; Masson, Riccardo ; Mercuri, Eugenio ; Rose, Kristy ; El-Khairi, Muna ; Gerber, Marianne ; Gorni, Ksenija ; Khwaja, Omar ; Kletzl, Heidemarie ; Scalco, Renata S ; Seabrook, Timothy ; Fontoura, Paulo ; Servais, Laurent

The New England journal of medicine, 2021-03, Vol.384 (10), p.915-923 [Periódico revisado por pares]

United States: Massachusetts Medical Society

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16
Synthesis of 2Ð-azolo[1,5-а][1,2,3]triazolo[4,5-е]pyrimidines
Synthesis of 2Ð-azolo[1,5-а][1,2,3]triazolo[4,5-е]pyrimidines
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Synthesis of 2Ð-azolo[1,5-а][1,2,3]triazolo[4,5-е]pyrimidines

Gorbunov, Evgeny B ; Rusinov, Gennady L ; Ulomskii, Evgeny N ; Isenov, Maksim L ; Charushin, Valery N

Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2015-05, Vol.51 (5), p.491 [Periódico revisado por pares]

Springer

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17
Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF / FGFR Aberrations: A Phase I Dose-Expansion Study
Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF / FGFR Aberrations: A Phase I Dose-Expansion Study
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Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF / FGFR Aberrations: A Phase I Dose-Expansion Study

Meric-Bernstam, Funda ; Bahleda, Rastislav ; Hierro, Cinta ; Sanson, Marc ; Bridgewater, John ; Arkenau, Hendrik-Tobias ; Tran, Ben ; Kelley, Robin Kate ; Park, Joon Oh ; Javle, Milind ; He, Yaohua ; Benhadji, Karim A ; Goyal, Lipika

Cancer discovery, 2022-02, Vol.12 (2), p.402-415

United States: American Association for Cancer Research

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18
Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
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Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

Byrd, John C ; Furman, Richard R ; Coutre, Steven E ; Flinn, Ian W ; Burger, Jan A ; Blum, Kristie A ; Grant, Barbara ; Sharman, Jeff P ; Coleman, Morton ; Wierda, William G ; Jones, Jeffrey A ; Zhao, Weiqiang ; Heerema, Nyla A ; Johnson, Amy J ; Sukbuntherng, Juthamas ; Chang, Betty Y ; Clow, Fong ; Hedrick, Eric ; Buggy, Joseph J ; James, Danelle F ; O'Brien, Susan

The New England journal of medicine, 2013-07, Vol.369 (1), p.32-42 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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19
Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial
Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial

Maher, Toby M ; van der Aar, Ellen M ; Van de Steen, Olivier ; Allamassey, Lisa ; Desrivot, Julie ; Dupont, Sonia ; Fagard, Liesbeth ; Ford, Paul ; Fieuw, Ann ; Wuyts, Wim

The lancet respiratory medicine, 2018-08, Vol.6 (8), p.627-635 [Periódico revisado por pares]

England: Elsevier Ltd

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20
Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery
Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery
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Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery

Li, Wen ; Zhang, Jinyang ; Wang, Min ; Dong, Ru ; Zhou, Xin ; Zheng, Xin ; Sun, Liping

Current topics in medicinal chemistry, 2022-02, Vol.22 (4), p.284-304 [Periódico revisado por pares]

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Deste Autor:

  1. Chiari, L
  2. Hurst, D
  3. Symposium on Purine and Pyrimidine Metabolism
  4. Silva, A

Neste Assunto:

  1. Science & Technology
  2. Life Sciences & Biomedicine
  3. Humans
  4. Pyrimidines
  5. Animals

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.