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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Canon, Jude ; Rex, Karen ; Saiki, Anne Y ; Mohr, Christopher ; Cooke, Keegan ; Bagal, Dhanashri ; Gaida, Kevin ; Holt, Tyler ; Knutson, Charles G ; Koppada, Neelima ; Lanman, Brian A ; Werner, Jonathan ; Rapaport, Aaron S ; San Miguel, Tisha ; Ortiz, Roberto ; Osgood, Tao ; Sun, Ji-Rong ; Zhu, Xiaochun ; McCarter, John D ; Volak, Laurie P ; Houk, Brett E ; Fakih, Marwan G ; O'Neil, Bert H ; Price, Timothy J ; Falchook, Gerald S ; Desai, Jayesh ; Kuo, James ; Govindan, Ramaswamy ; Hong, David S ; Ouyang, Wenjun ; Henary, Haby ; Arvedson, Tara ; Cee, Victor J ; Lipford, J Russell

Nature (London), 2019-11, Vol.575 (7781), p.217-223 [Periódico revisado por pares]

England: Nature Publishing Group

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2
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Khare, Shilpi ; Nagle, Advait S ; Biggart, Agnes ; Lai, Yin H ; Liang, Fang ; Davis, Lauren C ; Barnes, S Whitney ; Mathison, Casey J N ; Myburgh, Elmarie ; Gao, Mu-Yun ; Gillespie, J Robert ; Liu, Xianzhong ; Tan, Jocelyn L ; Stinson, Monique ; Rivera, Ianne C ; Ballard, Jaime ; Yeh, Vince ; Groessl, Todd ; Federe, Glenn ; Koh, Hazel X Y ; Venable, John D ; Bursulaya, Badry ; Shapiro, Michael ; Mishra, Pranab K ; Spraggon, Glen ; Brock, Ansgar ; Mottram, Jeremy C ; Buckner, Frederick S ; Rao, Srinivasa P S ; Wen, Ben G ; Walker, John R ; Tuntland, Tove ; Molteni, Valentina ; Glynne, Richard J ; Supek, Frantisek

Nature (London), 2016-09, Vol.537 (7619), p.229-233 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Selective small-molecule inhibition of an RNA structural element
Selective small-molecule inhibition of an RNA structural element
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Selective small-molecule inhibition of an RNA structural element

Howe, John A ; Wang, Hao ; Fischmann, Thierry O ; Balibar, Carl J ; Xiao, Li ; Galgoci, Andrew M ; Malinverni, Juliana C ; Mayhood, Todd ; Villafania, Artjohn ; Nahvi, Ali ; Murgolo, Nicholas ; Barbieri, Christopher M ; Mann, Paul A ; Carr, Donna ; Xia, Ellen ; Zuck, Paul ; Riley, Dan ; Painter, Ronald E ; Walker, Scott S ; Sherborne, Brad ; de Jesus, Reynalda ; Pan, Weidong ; Plotkin, Michael A ; Wu, Jin ; Rindgen, Diane ; Cummings, John ; Garlisi, Charles G ; Zhang, Rumin ; Sheth, Payal R ; Gill, Charles J ; Tang, Haifeng ; Roemer, Terry

Nature (London), 2015-10, Vol.526 (7575), p.672-677 [Periódico revisado por pares]

England: Nature Publishing Group

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4
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge ; Koolmeister, Tobias ; Jemth, Ann-Sofie ; Eshtad, Saeed ; Jacques, Sylvain A ; Ström, Cecilia E ; Svensson, Linda M ; Schultz, Niklas ; Lundbäck, Thomas ; Einarsdottir, Berglind Osk ; Saleh, Aljona ; Göktürk, Camilla ; Baranczewski, Pawel ; Svensson, Richard ; Berntsson, Ronnie P-A ; Gustafsson, Robert ; Strömberg, Kia ; Sanjiv, Kumar ; Jacques-Cordonnier, Marie-Caroline ; Desroses, Matthieu ; Gustavsson, Anna-Lena ; Olofsson, Roger ; Johansson, Fredrik ; Homan, Evert J ; Loseva, Olga ; Bräutigam, Lars ; Johansson, Lars ; Höglund, Andreas ; Hagenkort, Anna ; Pham, Therese ; Altun, Mikael ; Gaugaz, Fabienne Z ; Vikingsson, Svante ; Evers, Bastiaan ; Henriksson, Martin ; Vallin, Karl S A ; Wallner, Olov A ; Hammarström, Lars G J ; Wiita, Elisee ; Almlöf, Ingrid ; Kalderén, Christina ; Axelsson, Hanna ; Djureinovic, Tatjana ; Puigvert, Jordi Carreras ; Häggblad, Maria ; Jeppsson, Fredrik ; Martens, Ulf ; Lundin, Cecilia ; Lundgren, Bo ; Granelli, Ingrid ; Jensen, Annika Jenmalm ; Artursson, Per ; Nilsson, Jonas A ; Stenmark, Pål ; Scobie, Martin ; Berglund, Ulrika Warpman ; Helleday, Thomas

Nature (London), 2014-04, Vol.508 (7495), p.215-221 [Periódico revisado por pares]

England: Nature Publishing Group

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5
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy, András ; Szlavik, Zoltán ; Murray, James ; Davidson, James ; Maragno, Ana Leticia ; Le Toumelin-Braizat, Gaëtane ; Chanrion, Maïa ; Kelly, Gemma L ; Gong, Jia-Nan ; Moujalled, Donia M ; Bruno, Alain ; Csekei, Márton ; Paczal, Attila ; Szabo, Zoltán B ; Sipos, Szabolcs ; Radics, Gábor ; Proszenyak, Agnes ; Balint, Balázs ; Ondi, Levente ; Blasko, Gábor ; Robertson, Alan ; Surgenor, Allan ; Dokurno, Pawel ; Chen, Ijen ; Matassova, Natalia ; Smith, Julia ; Pedder, Christopher ; Graham, Christopher ; Studeny, Aurélie ; Lysiak-Auvity, Gaëlle ; Girard, Anne-Marie ; Gravé, Fabienne ; Segal, David ; Riffkin, Chris D ; Pomilio, Giovanna ; Galbraith, Laura C A ; Aubrey, Brandon J ; Brennan, Margs S ; Herold, Marco J ; Chang, Catherine ; Guasconi, Ghislaine ; Cauquil, Nicolas ; Melchiore, Fabien ; Guigal-Stephan, Nolwen ; Lockhart, Brian ; Colland, Frédéric ; Hickman, John A ; Roberts, Andrew W ; Huang, David C S ; Wei, Andrew H ; Strasser, Andreas ; Lessene, Guillaume ; Geneste, Olivier

Nature (London), 2016-10, Vol.538 (7626), p.477-482 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Chen, Ying-Nan P ; LaMarche, Matthew J ; Chan, Ho Man ; Fekkes, Peter ; Garcia-Fortanet, Jorge ; Acker, Michael G ; Antonakos, Brandon ; Chen, Christine Hiu-Tung ; Chen, Zhouliang ; Cooke, Vesselina G ; Dobson, Jason R ; Deng, Zhan ; Fei, Feng ; Firestone, Brant ; Fodor, Michelle ; Fridrich, Cary ; Gao, Hui ; Grunenfelder, Denise ; Hao, Huai-Xiang ; Jacob, Jaison ; Ho, Samuel ; Hsiao, Kathy ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Larrow, Jay ; La Bonte, Laura R ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Price, Edmund ; Quinn, Christopher ; Shakya, Subarna ; Shultz, Michael D ; Slisz, Joanna ; Venkatesan, Kavitha ; Wang, Ping ; Warmuth, Markus ; Williams, Sarah ; Yang, Guizhi ; Yuan, Jing ; Zhang, Ji-Hu ; Zhu, Ping ; Ramsey, Timothy ; Keen, Nicholas J ; Sellers, William R ; Stams, Travis ; Fortin, Pascal D

Nature (London), 2016-07, Vol.535 (7610), p.148-152 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Switching on prodrugs using radiotherapy
Switching on prodrugs using radiotherapy
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Switching on prodrugs using radiotherapy

Geng, Jin ; Zhang, Yichuan ; Gao, Quan ; Neumann, Kevin ; Dong, Hua ; Porter, Hamish ; Potter, Mark ; Ren, Hua ; Argyle, David ; Bradley, Mark

Nature chemistry, 2021-08, Vol.13 (8), p.805-810 [Periódico revisado por pares]

England: Nature Publishing Group

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8
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, Jiyeon ; Hu, Zeping ; Cai, Ling ; Li, Kailong ; Choi, Eunhee ; Faubert, Brandon ; Bezwada, Divya ; Rodriguez-Canales, Jaime ; Villalobos, Pamela ; Lin, Yu-Fen ; Ni, Min ; Huffman, Kenneth E ; Girard, Luc ; Byers, Lauren A ; Unsal-Kacmaz, Keziban ; Peña, Christopher G ; Heymach, John V ; Wauters, Els ; Vansteenkiste, Johan ; Castrillon, Diego H ; Chen, Benjamin P C ; Wistuba, Ignacio ; Lambrechts, Diether ; Xu, Jian ; Minna, John D ; DeBerardinis, Ralph J

Nature (London), 2017-06, Vol.546 (7656), p.168-172 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, Susan ; Thomas, Michael ; Patterson, Stephen ; Crouch, Sabrinia ; De Rycker, Manu ; Lowe, Rhiannon ; Gresham, Stephanie ; Urbaniak, Michael D ; Otto, Thomas D ; Stojanovski, Laste ; Simeons, Frederick R C ; Manthri, Sujatha ; MacLean, Lorna M ; Zuccotto, Fabio ; Homeyer, Nadine ; Pflaumer, Hannah ; Boesche, Markus ; Sastry, Lalitha ; Connolly, Paul ; Albrecht, Sebastian ; Berriman, Matt ; Drewes, Gerard ; Gray, David W ; Ghidelli-Disse, Sonja ; Dixon, Susan ; Fiandor, Jose M ; Wyatt, Paul G ; Ferguson, Michael A J ; Fairlamb, Alan H ; Miles, Timothy J ; Read, Kevin D ; Gilbert, Ian H

Nature (London), 2018-08, Vol.560 (7717), p.192-197 [Periódico revisado por pares]

England: Nature Publishing Group

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10
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
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Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

Force, Thomas ; Kerkelä, Risto ; Grazette, Luanda ; Yacobi, Rinat ; Iliescu, Cezar ; Patten, Richard ; Beahm, Cara ; Walters, Brian ; Shevtsov, Sergei ; Pesant, Stéphanie ; Clubb, Fred J ; Rosenzweig, Anthony ; Salomon, Robert N ; Van Etten, Richard A ; Alroy, Joseph ; Durand, Jean-Bernard

Nature medicine, 2006-08, Vol.12 (8), p.908-916 [Periódico revisado por pares]

United States: Nature Publishing Group

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