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Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial
Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial
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Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial

Camidge, D Ross ; Kim, Hye Ryun ; Ahn, Myung-Ju ; Yang, James C H ; Han, Ji-Youn ; Hochmair, Maximilian J ; Lee, Ki Hyeong ; Delmonte, Angelo ; García Campelo, Maria Rosario ; Kim, Dong-Wan ; Griesinger, Frank ; Felip, Enriqueta ; Califano, Raffaele ; Spira, Alexander ; Gettinger, Scott N ; Tiseo, Marcello ; Lin, Huamao M ; Gupta, Neeraj ; Hanley, Michael J ; Ni, Quanhong ; Zhang, Pingkuan ; Popat, Sanjay

Journal of clinical oncology, 2020-11, Vol.38 (31), p.3592-3603 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

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2
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Canon, Jude ; Rex, Karen ; Saiki, Anne Y ; Mohr, Christopher ; Cooke, Keegan ; Bagal, Dhanashri ; Gaida, Kevin ; Holt, Tyler ; Knutson, Charles G ; Koppada, Neelima ; Lanman, Brian A ; Werner, Jonathan ; Rapaport, Aaron S ; San Miguel, Tisha ; Ortiz, Roberto ; Osgood, Tao ; Sun, Ji-Rong ; Zhu, Xiaochun ; McCarter, John D ; Volak, Laurie P ; Houk, Brett E ; Fakih, Marwan G ; O'Neil, Bert H ; Price, Timothy J ; Falchook, Gerald S ; Desai, Jayesh ; Kuo, James ; Govindan, Ramaswamy ; Hong, David S ; Ouyang, Wenjun ; Henary, Haby ; Arvedson, Tara ; Cee, Victor J ; Lipford, J Russell

Nature (London), 2019-11, Vol.575 (7781), p.217-223 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study
Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study
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Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study

Nogova, Lucia ; Sequist, Lecia V ; Perez Garcia, Jose Manuel ; Andre, Fabrice ; Delord, Jean-Pierre ; Hidalgo, Manuel ; Schellens, Jan H M ; Cassier, Philippe A ; Camidge, D Ross ; Schuler, Martin ; Vaishampayan, Ulka ; Burris, Howard ; Tian, G Gary ; Campone, Mario ; Wainberg, Zev A ; Lim, Wan-Teck ; LoRusso, Patricia ; Shapiro, Geoffrey I ; Parker, Katie ; Chen, Xueying ; Choudhury, Somesh ; Ringeisen, Francois ; Graus-Porta, Diana ; Porter, Dale ; Isaacs, Randi ; Buettner, Reinhard ; Wolf, Jürgen

Journal of clinical oncology, 2017-01, Vol.35 (2), p.157-165 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

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4
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Arias-Gómez, Andres ; Godoy, Andrés ; Portilla, Jaime

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2708 [Periódico revisado por pares]

Switzerland: MDPI AG

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5
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
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Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines

Naglah, Ahmed M ; Askar, Ahmed A ; Hassan, Ashraf S ; Khatab, Tamer K ; Al-Omar, Mohamed A ; Bhat, Mashooq A

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1431 [Periódico revisado por pares]

Switzerland: MDPI AG

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6
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Khare, Shilpi ; Nagle, Advait S ; Biggart, Agnes ; Lai, Yin H ; Liang, Fang ; Davis, Lauren C ; Barnes, S Whitney ; Mathison, Casey J N ; Myburgh, Elmarie ; Gao, Mu-Yun ; Gillespie, J Robert ; Liu, Xianzhong ; Tan, Jocelyn L ; Stinson, Monique ; Rivera, Ianne C ; Ballard, Jaime ; Yeh, Vince ; Groessl, Todd ; Federe, Glenn ; Koh, Hazel X Y ; Venable, John D ; Bursulaya, Badry ; Shapiro, Michael ; Mishra, Pranab K ; Spraggon, Glen ; Brock, Ansgar ; Mottram, Jeremy C ; Buckner, Frederick S ; Rao, Srinivasa P S ; Wen, Ben G ; Walker, John R ; Tuntland, Tove ; Molteni, Valentina ; Glynne, Richard J ; Supek, Frantisek

Nature (London), 2016-09, Vol.537 (7619), p.229-233 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Selective small-molecule inhibition of an RNA structural element
Selective small-molecule inhibition of an RNA structural element
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Selective small-molecule inhibition of an RNA structural element

Howe, John A ; Wang, Hao ; Fischmann, Thierry O ; Balibar, Carl J ; Xiao, Li ; Galgoci, Andrew M ; Malinverni, Juliana C ; Mayhood, Todd ; Villafania, Artjohn ; Nahvi, Ali ; Murgolo, Nicholas ; Barbieri, Christopher M ; Mann, Paul A ; Carr, Donna ; Xia, Ellen ; Zuck, Paul ; Riley, Dan ; Painter, Ronald E ; Walker, Scott S ; Sherborne, Brad ; de Jesus, Reynalda ; Pan, Weidong ; Plotkin, Michael A ; Wu, Jin ; Rindgen, Diane ; Cummings, John ; Garlisi, Charles G ; Zhang, Rumin ; Sheth, Payal R ; Gill, Charles J ; Tang, Haifeng ; Roemer, Terry

Nature (London), 2015-10, Vol.526 (7575), p.672-677 [Periódico revisado por pares]

England: Nature Publishing Group

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8
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge ; Koolmeister, Tobias ; Jemth, Ann-Sofie ; Eshtad, Saeed ; Jacques, Sylvain A ; Ström, Cecilia E ; Svensson, Linda M ; Schultz, Niklas ; Lundbäck, Thomas ; Einarsdottir, Berglind Osk ; Saleh, Aljona ; Göktürk, Camilla ; Baranczewski, Pawel ; Svensson, Richard ; Berntsson, Ronnie P-A ; Gustafsson, Robert ; Strömberg, Kia ; Sanjiv, Kumar ; Jacques-Cordonnier, Marie-Caroline ; Desroses, Matthieu ; Gustavsson, Anna-Lena ; Olofsson, Roger ; Johansson, Fredrik ; Homan, Evert J ; Loseva, Olga ; Bräutigam, Lars ; Johansson, Lars ; Höglund, Andreas ; Hagenkort, Anna ; Pham, Therese ; Altun, Mikael ; Gaugaz, Fabienne Z ; Vikingsson, Svante ; Evers, Bastiaan ; Henriksson, Martin ; Vallin, Karl S A ; Wallner, Olov A ; Hammarström, Lars G J ; Wiita, Elisee ; Almlöf, Ingrid ; Kalderén, Christina ; Axelsson, Hanna ; Djureinovic, Tatjana ; Puigvert, Jordi Carreras ; Häggblad, Maria ; Jeppsson, Fredrik ; Martens, Ulf ; Lundin, Cecilia ; Lundgren, Bo ; Granelli, Ingrid ; Jensen, Annika Jenmalm ; Artursson, Per ; Nilsson, Jonas A ; Stenmark, Pål ; Scobie, Martin ; Berglund, Ulrika Warpman ; Helleday, Thomas

Nature (London), 2014-04, Vol.508 (7495), p.215-221 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors
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Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

Do, Khanh ; Wilsker, Deborah ; Ji, Jiuping ; Zlott, Jennifer ; Freshwater, Tomoko ; Kinders, Robert J ; Collins, Jerry ; Chen, Alice P ; Doroshow, James H ; Kummar, Shivaani

Journal of clinical oncology, 2015-10, Vol.33 (30), p.3409-3415 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

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10
Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial
Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial
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Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial

Silverberg, Jonathan I ; Simpson, Eric L ; Thyssen, Jacob P ; Gooderham, Melinda ; Chan, Gary ; Feeney, Claire ; Biswas, Pinaki ; Valdez, Hernan ; DiBonaventura, Marco ; Nduaka, Chudy ; Rojo, Ricardo

Archives of dermatology (1960), 2020-08, Vol.156 (8), p.863-873 [Periódico revisado por pares]

United States: American Medical Association

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