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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
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Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Arias-Gómez, Andres ; Godoy, Andrés ; Portilla, Jaime

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2708 [Periódico revisado por pares]

Switzerland: MDPI AG

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2
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines
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Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5- a ]pyrimidines

Naglah, Ahmed M ; Askar, Ahmed A ; Hassan, Ashraf S ; Khatab, Tamer K ; Al-Omar, Mohamed A ; Bhat, Mashooq A

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1431 [Periódico revisado por pares]

Switzerland: MDPI AG

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3
Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor
Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor
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Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor

Kato, Noriyasu ; Oka, Mitsuru ; Murase, Takayo ; Yoshida, Masahiro ; Sakairi, Masao ; Yamashita, Satoko ; Yasuda, Yoshika ; Yoshikawa, Aya ; Hayashi, Yuuji ; Makino, Mitsuhiro ; Takeda, Motohiro ; Mirensha, Yakufu ; Kakigami, Takuji

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7221-7227 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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4
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review
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Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review

Chauhan, Monika ; Kumar, Raj

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (18), p.5657-5668 [Periódico revisado por pares]

England: Elsevier Ltd

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5
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

Lee, Joo Sang ; Adler, Lital ; Karathia, Hiren ; Carmel, Narin ; Rabinovich, Shiran ; Auslander, Noam ; Keshet, Rom ; Stettner, Noa ; Silberman, Alon ; Agemy, Lilach ; Helbling, Daniel ; Eilam, Raya ; Sun, Qin ; Brandis, Alexander ; Malitsky, Sergey ; Itkin, Maxim ; Weiss, Hila ; Pinto, Sivan ; Kalaora, Shelly ; Levy, Ronen ; Barnea, Eilon ; Admon, Arie ; Dimmock, David ; Stern-Ginossar, Noam ; Scherz, Avigdor ; Nagamani, Sandesh C.S. ; Unda, Miguel ; Wilson, David M. ; Elhasid, Ronit ; Carracedo, Arkaitz ; Samuels, Yardena ; Hannenhalli, Sridhar ; Ruppin, Eytan ; Erez, Ayelet

Cell, 2018-09, Vol.174 (6), p.1559-1570.e22 [Periódico revisado por pares]

United States: Elsevier Inc

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6
Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors
Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors
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Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors

Musumeci, Francesca ; Sanna, Monica ; Grossi, Giancarlo ; Brullo, Chiara ; Fallacara, Anna Lucia ; Schenone, Silvia

Current medicinal chemistry, 2017-06, Vol.24 (19), p.2059-2085 [Periódico revisado por pares]

United Arab Emirates: Bentham Science Publishers Ltd

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7
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne ; Kuplast, Kristy G ; Majer, Christina R ; Boriack-Sjodin, P Ann ; Wigle, Tim J ; Johnston, L Danielle ; Rioux, Nathalie ; Munchhof, Michael J ; Jin, Lei ; Jacques, Suzanne L ; West, Kip A ; Lingaraj, Trupti ; Stickland, Kimberly ; Ribich, Scott A ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J ; Pollock, Roy M ; Smith, Jesse J ; Barbash, Olena ; Pappalardi, Melissa ; Ho, Thau F ; Nurse, Kelvin ; Oza, Khyati P ; Gallagher, Kathleen T ; Kruger, Ryan ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard ; Duncan, Kenneth W

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437 [Periódico revisado por pares]

United States: Nature Publishing Group

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8
In silico design of novel probes for the atypical opioid receptor MRGPRX2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, Katherine ; Karpiak, Joel ; Liu, Jing ; Huang, Xi-Ping ; McCorvy, John D ; Kroeze, Wesley K ; Che, Tao ; Nagase, Hiroshi ; Carroll, Frank I ; Jin, Jian ; Shoichet, Brian K ; Roth, Bryan L

Nature chemical biology, 2017-05, Vol.13 (5), p.529-536 [Periódico revisado por pares]

United States: Nature Publishing Group

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9
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Zhang, Tinghu ; Kwiatkowski, Nicholas ; Olson, Calla M ; Dixon-Clarke, Sarah E ; Abraham, Brian J ; Greifenberg, Ann K ; Ficarro, Scott B ; Elkins, Jonathan M ; Liang, Yanke ; Hannett, Nancy M ; Manz, Theresa ; Hao, Mingfeng ; Bartkowiak, Bartlomiej ; Greenleaf, Arno L ; Marto, Jarrod A ; Geyer, Matthias ; Bullock, Alex N ; Young, Richard A ; Gray, Nathanael S

Nature chemical biology, 2016-10, Vol.12 (10), p.876-884 [Periódico revisado por pares]

United States: Nature Publishing Group

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10
Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
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Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety

Li, Changkun ; Liu, Youhua ; Ren, Xiaoli ; Tan, Yanni ; Jin, Linhong ; Zhou, Xia

International journal of molecular sciences, 2023-02, Vol.24 (5), p.4691 [Periódico revisado por pares]

Switzerland: MDPI AG

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