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1
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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Artigo
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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Canon, Jude ; Rex, Karen ; Saiki, Anne Y ; Mohr, Christopher ; Cooke, Keegan ; Bagal, Dhanashri ; Gaida, Kevin ; Holt, Tyler ; Knutson, Charles G ; Koppada, Neelima ; Lanman, Brian A ; Werner, Jonathan ; Rapaport, Aaron S ; San Miguel, Tisha ; Ortiz, Roberto ; Osgood, Tao ; Sun, Ji-Rong ; Zhu, Xiaochun ; McCarter, John D ; Volak, Laurie P ; Houk, Brett E ; Fakih, Marwan G ; O'Neil, Bert H ; Price, Timothy J ; Falchook, Gerald S ; Desai, Jayesh ; Kuo, James ; Govindan, Ramaswamy ; Hong, David S ; Ouyang, Wenjun ; Henary, Haby ; Arvedson, Tara ; Cee, Victor J ; Lipford, J Russell

Nature (London), 2019-11, Vol.575 (7781), p.217-223 [Periódico revisado por pares]

England: Nature Publishing Group

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2
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
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Artigo
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Khare, Shilpi ; Nagle, Advait S ; Biggart, Agnes ; Lai, Yin H ; Liang, Fang ; Davis, Lauren C ; Barnes, S Whitney ; Mathison, Casey J N ; Myburgh, Elmarie ; Gao, Mu-Yun ; Gillespie, J Robert ; Liu, Xianzhong ; Tan, Jocelyn L ; Stinson, Monique ; Rivera, Ianne C ; Ballard, Jaime ; Yeh, Vince ; Groessl, Todd ; Federe, Glenn ; Koh, Hazel X Y ; Venable, John D ; Bursulaya, Badry ; Shapiro, Michael ; Mishra, Pranab K ; Spraggon, Glen ; Brock, Ansgar ; Mottram, Jeremy C ; Buckner, Frederick S ; Rao, Srinivasa P S ; Wen, Ben G ; Walker, John R ; Tuntland, Tove ; Molteni, Valentina ; Glynne, Richard J ; Supek, Frantisek

Nature (London), 2016-09, Vol.537 (7619), p.229-233 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Selective small-molecule inhibition of an RNA structural element
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Artigo
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Selective small-molecule inhibition of an RNA structural element

Howe, John A ; Wang, Hao ; Fischmann, Thierry O ; Balibar, Carl J ; Xiao, Li ; Galgoci, Andrew M ; Malinverni, Juliana C ; Mayhood, Todd ; Villafania, Artjohn ; Nahvi, Ali ; Murgolo, Nicholas ; Barbieri, Christopher M ; Mann, Paul A ; Carr, Donna ; Xia, Ellen ; Zuck, Paul ; Riley, Dan ; Painter, Ronald E ; Walker, Scott S ; Sherborne, Brad ; de Jesus, Reynalda ; Pan, Weidong ; Plotkin, Michael A ; Wu, Jin ; Rindgen, Diane ; Cummings, John ; Garlisi, Charles G ; Zhang, Rumin ; Sheth, Payal R ; Gill, Charles J ; Tang, Haifeng ; Roemer, Terry

Nature (London), 2015-10, Vol.526 (7575), p.672-677 [Periódico revisado por pares]

England: Nature Publishing Group

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4
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
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Artigo
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge ; Koolmeister, Tobias ; Jemth, Ann-Sofie ; Eshtad, Saeed ; Jacques, Sylvain A ; Ström, Cecilia E ; Svensson, Linda M ; Schultz, Niklas ; Lundbäck, Thomas ; Einarsdottir, Berglind Osk ; Saleh, Aljona ; Göktürk, Camilla ; Baranczewski, Pawel ; Svensson, Richard ; Berntsson, Ronnie P-A ; Gustafsson, Robert ; Strömberg, Kia ; Sanjiv, Kumar ; Jacques-Cordonnier, Marie-Caroline ; Desroses, Matthieu ; Gustavsson, Anna-Lena ; Olofsson, Roger ; Johansson, Fredrik ; Homan, Evert J ; Loseva, Olga ; Bräutigam, Lars ; Johansson, Lars ; Höglund, Andreas ; Hagenkort, Anna ; Pham, Therese ; Altun, Mikael ; Gaugaz, Fabienne Z ; Vikingsson, Svante ; Evers, Bastiaan ; Henriksson, Martin ; Vallin, Karl S A ; Wallner, Olov A ; Hammarström, Lars G J ; Wiita, Elisee ; Almlöf, Ingrid ; Kalderén, Christina ; Axelsson, Hanna ; Djureinovic, Tatjana ; Puigvert, Jordi Carreras ; Häggblad, Maria ; Jeppsson, Fredrik ; Martens, Ulf ; Lundin, Cecilia ; Lundgren, Bo ; Granelli, Ingrid ; Jensen, Annika Jenmalm ; Artursson, Per ; Nilsson, Jonas A ; Stenmark, Pål ; Scobie, Martin ; Berglund, Ulrika Warpman ; Helleday, Thomas

Nature (London), 2014-04, Vol.508 (7495), p.215-221 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Novel Pyrimidines as Antitubercular Agents
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Artigo
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Novel Pyrimidines as Antitubercular Agents

Inoyama, Daigo ; Paget, Steven D ; Russo, Riccardo ; Kandasamy, Srinivasan ; Kumar, Pradeep ; Singleton, Eric ; Occi, James ; Tuckman, Margareta ; Zimmerman, Matthew D ; Ho, Hsin Pin ; Perryman, Alexander L ; Dartois, Véronique ; Connell, Nancy ; Freundlich, Joel S

Antimicrobial agents and chemotherapy, 2018-03, Vol.62 (3) [Periódico revisado por pares]

United States: American Society for Microbiology

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6
Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
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Artigo
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Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors

Azeredo, Luís Felipe S.P. ; Coutinho, Julia P. ; Jabor, Valquiria A.P. ; Feliciano, Patricia R. ; Nonato, Maria Cristina ; Kaiser, Carlos R. ; Menezes, Carla Maria S. ; Hammes, Amanda S.O. ; Caffarena, Ernesto Raul ; Hoelz, Lucas V.B. ; de Souza, Nicolli B. ; Pereira, Glaécia A.N. ; Cerávolo, Isabela P. ; Krettli, Antoniana U. ; Boechat, Nubia

European journal of medicinal chemistry, 2017-01, Vol.126, p.72-83 [Periódico revisado por pares]

France: Elsevier Masson SAS

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7
Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation
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Artigo
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Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation

Pfaffenbach, Magnus ; Bolduc, Philippe N. ; Xin, Zhili ; Gao, Fang ; Evans, Ryan ; Fang, Terry ; Chodaparambil, Jayanth V. ; Henry, Kate L. ; Li, Pei ; Mathieu, Steven ; Metrick, Claire ; Vera Rebollar, Jorge A. ; Gu, Rong-Fang ; Mccarl, Christie-Ann ; Silbereis, John ; Peterson, Emily A.

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8383-8395 [Periódico revisado por pares]

United States: American Chemical Society

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8
Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
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Artigo
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Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Honigberg, Lee A ; Smith, Ashley M ; Sirisawad, Mint ; Verner, Erik ; Loury, David ; Chang, Betty ; Li, Shyr ; Pan, Zhengying ; Thamm, Douglas H ; Miller, Richard A ; Buggy, Joseph J

Proceedings of the National Academy of Sciences - PNAS, 2010-07, Vol.107 (29), p.13075-13080 [Periódico revisado por pares]

United States: National Academy of Sciences

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9
Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2- a]pyrimidines
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Artigo
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Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2- a]pyrimidines

El-Sayed, Nadia S. ; El-Bendary, Eman R. ; El-Ashry, Saadia M. ; El-Kerdawy, Mohammed M.

European journal of medicinal chemistry, 2011-09, Vol.46 (9), p.3714-3720 [Periódico revisado por pares]

Kidlington: Elsevier Masson SAS

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10
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
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Artigo
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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Dilger, Andrew K ; Pabbisetty, Kumar B ; Corte, James R ; De Lucca, Indawati ; Fang, Tianan ; Yang, Wu ; Pinto, Donald J. P ; Wang, Yufeng ; Zhu, Yeheng ; Mathur, Arvind ; Li, Jianqing ; Hou, Xiaoping ; Smith, Daniel ; Sun, Dawn ; Zhang, Huiping ; Krishnananthan, Subramaniam ; Wu, Dauh-Rurng ; Myers, Joseph E ; Sheriff, Steven ; Rossi, Karen A ; Chacko, Silvi ; Zheng, Joanna J ; Galella, Michael A ; Ziemba, Theresa ; Dierks, Elizabeth A ; Bozarth, Jeffrey M ; Wu, Yiming ; Crain, Earl ; Wong, Pancras C ; Luettgen, Joseph M ; Wexler, Ruth R ; Ewing, William R

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1770-1785 [Periódico revisado por pares]

United States: American Chemical Society

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