Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Farago, Anna F ; Yeap, Beow Y ; Stanzione, Marcello ; Hung, Yin P ; Heist, Rebecca S ; Marcoux, J Paul ; Zhong, Jun ; Rangachari, Deepa ; Barbie, David A ; Phat, Sarah ; Myers, David T ; Morris, Robert ; Kem, Marina ; Dubash, Taronish D ; Kennedy, Elizabeth A ; Digumarthy, Subba R ; Sequist, Lecia V ; Hata, Aaron N ; Maheswaran, Shyamala ; Haber, Daniel A ; Lawrence, Michael S ; Shaw, Alice T ; Mino-Kenudson, Mari ; Dyson, Nicholas J ; Drapkin, Benjamin J

United States

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Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)

Drilon, Alexander ; Siena, Salvatore ; Ou, Sai-Hong Ignatius ; Patel, Manish ; Ahn, Myung Ju ; Lee, Jeeyun ; Bauer, Todd M ; Farago, Anna F ; Wheler, Jennifer J ; Liu, Stephen V ; Doebele, Robert ; Giannetta, Laura ; Cerea, Giulio ; Marrapese, Giovanna ; Schirru, Michele ; Amatu, Alessio ; Bencardino, Katia ; Palmeri, Laura ; Sartore-Bianchi, Andrea ; Vanzulli, Angelo ; Cresta, Sara ; Damian, Silvia ; Duca, Matteo ; Ardini, Elena ; Li, Gang ; Christiansen, Jason ; Kowalski, Karey ; Johnson, Ann D ; Patel, Rupal ; Luo, David ; Chow-Maneval, Edna ; Hornby, Zachary ; Multani, Pratik S ; Shaw, Alice T ; De Braud, Filippo G

United States

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Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study

Morgensztern, Daniel ; Besse, Benjamin ; Greillier, Laurent ; Santana-Davila, Rafael ; Ready, Neal ; Hann, Christine L ; Glisson, Bonnie S ; Farago, Anna F ; Dowlati, Afshin ; Rudin, Charles M ; Le Moulec, Sylvestre ; Lally, Satwant ; Yalamanchili, Sreeni ; Wolf, Jürgen ; Govindan, Ramaswamy ; Carbone, David P

United States

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EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis

Gainor, Justin F ; Shaw, Alice T ; Sequist, Lecia V ; Fu, Xiujun ; Azzoli, Christopher G ; Piotrowska, Zofia ; Huynh, Tiffany G ; Zhao, Ling ; Fulton, Linnea ; Schultz, Katherine R ; Howe, Emily ; Farago, Anna F ; Sullivan, Ryan J ; Stone, James R ; Digumarthy, Subba ; Moran, Teresa ; Hata, Aaron N ; Yagi, Yukako ; Yeap, Beow Y ; Engelman, Jeffrey A ; Mino-Kenudson, Mari

United States

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Treatment with Next-Generation ALK Inhibitors Fuels Plasma ALK Mutation Diversity

Dagogo-Jack, Ibiayi ; Rooney, Marguerite ; Lin, Jessica J ; Nagy, Rebecca J ; Yeap, Beow Y ; Hubbeling, Harper ; Chin, Emily ; Ackil, Jennifer ; Farago, Anna F ; Hata, Aaron N ; Lennerz, Jochen K ; Gainor, Justin F ; Lanman, Richard B ; Shaw, Alice T

United States

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Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer

Nangia, Varuna ; Siddiqui, Faria M ; Caenepeel, Sean ; Timonina, Daria ; Bilton, Samantha J ; Phan, Nicole ; Gomez-Caraballo, Maria ; Archibald, Hannah L ; Li, Chendi ; Fraser, Cameron ; Rigas, Diamanda ; Vajda, Kristof ; Ferris, Lorin A ; Lanuti, Michael ; Wright, Cameron D ; Raskin, Kevin A ; Cahill, Daniel P ; Shin, John H ; Keyes, Colleen ; Sequist, Lecia V ; Piotrowska, Zofia ; Farago, Anna F ; Azzoli, Christopher G ; Gainor, Justin F ; Sarosiek, Kristopher A ; Brown, Sean P ; Coxon, Angela ; Benes, Cyril H ; Hughes, Paul E ; Hata, Aaron N

United States

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Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

Pal Choudhuri, Shreoshi ; Girard, Luc ; Lim, Jun Yi Stanley ; Wise, Jillian F ; Freitas, Braeden ; Yang, Di ; Wong, Edmond ; Hamilton, Seth ; Chien, Victor D ; Kim, Yoon Jung ; Gilbreath, Collin ; Zhong, Jun ; Phat, Sarah ; Myers, David T ; Christensen, Camilla L ; Mazloom-Farsibaf, Hanieh ; Stanzione, Marcello ; Wong, Kwok-Kin ; Hung, Yin P ; Farago, Anna F ; Meador, Catherine B ; Dyson, Nicholas J ; Lawrence, Michael S ; Wu, Sihan ; Drapkin, Benjamin J

United States: American Association for Cancer Research

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Weiss, Andreas ; Lorthiois, Edwige ; Barys, Louise ; Beyer, Kim S ; Bomio-Confaglia, Claudio ; Burks, Heather ; Chen, Xueying ; Cui, Xiaoming ; de Kanter, Ruben ; Dharmarajan, Lekshmi ; Fedele, Carmine ; Gerspacher, Marc ; Guthy, Daniel Alexander ; Head, Victoria ; Jaeger, Ashley ; Núñez, Eloísa Jiménez ; Kearns, Jeffrey D ; Leblanc, Catherine ; Maira, Sauveur-Michel ; Murphy, Jason ; Oakman, Helen ; Ostermann, Nils ; Ottl, Johannes ; Rigollier, Pascal ; Roman, Danielle ; Schnell, Christian ; Sedrani, Richard ; Shimizu, Toshio ; Stringer, Rowan ; Vaupel, Andrea ; Voshol, Hans ; Wessels, Peter ; Widmer, Toni ; Wilcken, Rainer ; Xu, Kun ; Zecri, Frederic ; Farago, Anna F ; Cotesta, Simona ; Brachmann, Saskia M

United States: American Association for Cancer Research

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Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

Drapkin, Benjamin J ; George, Julie ; Christensen, Camilla L ; Mino-Kenudson, Mari ; Dries, Ruben ; Sundaresan, Tilak ; Phat, Sarah ; Myers, David T ; Zhong, Jun ; Igo, Peter ; Hazar-Rethinam, Mehlika H ; Licausi, Joseph A ; Gomez-Caraballo, Maria ; Kem, Marina ; Jani, Kandarp N ; Azimi, Roxana ; Abedpour, Nima ; Menon, Roopika ; Lakis, Sotirios ; Heist, Rebecca S ; Büttner, Reinhard ; Haas, Stefan ; Sequist, Lecia V ; Shaw, Alice T ; Wong, Kwok-Kin ; Hata, Aaron N ; Toner, Mehmet ; Maheswaran, Shyamala ; Haber, Daniel A ; Peifer, Martin ; Dyson, Nicholas ; Thomas, Roman K ; Farago, Anna F

United States

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Abstract CT199: Larotrectinib in TRK fusion cancer patients: Outcomes by prior therapy and performance status

Drilon, Alexander ; van Tilburg, Cornelis M. ; Farago, Anna F. ; Kummar, Shivaani ; Berlin, Jordan ; Albert, Catherine M. ; McDermott, Ray ; Lassen, Ulrik N. ; Reeves, John A. ; Brega, Nicoletta ; Childs, Barrett H. ; Laetsch, Theodore W. ; Hong, David S.

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