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Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
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Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Carretero, Julian ; Shimamura, Takeshi ; Rikova, Klarisa ; Jackson, Autumn L. ; Wilkerson, Matthew D. ; Borgman, Christa L. ; Buttarazzi, Matthew S. ; Sanofsky, Benjamin A. ; McNamara, Kate L. ; Brandstetter, Kathleyn A. ; Walton, Zandra E. ; Gu, Ting-Lei ; Silva, Jeffrey C. ; Crosby, Katherine ; Shapiro, Geoffrey I. ; Maira, Sauveur-Michel ; Ji, Hongbin ; Castrillon, Diego H. ; Kim, Carla F. ; García-Echeverría, Carlos ; Bardeesy, Nabeel ; Sharpless, Norman E. ; Hayes, Neil D. ; Kim, William Y. ; Engelman, Jeffrey A. ; Wong, Kwok-Kin

Cancer cell, 2010-06, Vol.17 (6), p.547-559 [Periódico revisado por pares]

United States: Elsevier Inc

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

Herman, Sarah E.M. ; Gordon, Amber L. ; Hertlein, Erin ; Ramanunni, Asha ; Zhang, Xiaoli ; Jaglowski, Samantha ; Flynn, Joseph ; Jones, Jeffrey ; Blum, Kristie A. ; Buggy, Joseph J. ; Hamdy, Ahmed ; Johnson, Amy J. ; Byrd, John C.

Blood, 2011-06, Vol.117 (23), p.6287-6296 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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3
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Sun, Chong ; Wang, Liqin ; Huang, Sidong ; Heynen, Guus J J E ; Prahallad, Anirudh ; Robert, Caroline ; Haanen, John ; Blank, Christian ; Wesseling, Jelle ; Willems, Stefan M ; Zecchin, Davide ; Hobor, Sebastijan ; Bajpe, Prashanth K ; Lieftink, Cor ; Mateus, Christina ; Vagner, Stephan ; Grernrum, Wipawadee ; Hofland, Ingrid ; Schlicker, Andreas ; Wessels, Lodewyk F A ; Beijersbergen, Roderick L ; Bardelli, Alberto ; Di Nicolantonio, Federica ; Eggermont, Alexander M M ; Bernards, Rene

Nature (London), 2014-04, Vol.508 (7494), p.118-122 [Periódico revisado por pares]

England: Nature Publishing Group

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4
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Chandarlapaty, Sarat ; Sawai, Ayana ; Scaltriti, Maurizio ; Rodrik-Outmezguine, Vanessa ; Grbovic-Huezo, Olivera ; Serra, Violeta ; Majumder, Pradip K. ; Baselga, Jose ; Rosen, Neal

Cancer cell, 2011-01, Vol.19 (1), p.58-71 [Periódico revisado por pares]

United States: Elsevier Inc

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5
Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer
Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer
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Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer

Wang, Qingfei ; Guldner, Ian H ; Golomb, Samantha M ; Sun, Longhua ; Harris, Jack A ; Lu, Xin ; Zhang, Siyuan

Nature communications, 2019-08, Vol.10 (1), p.3817-12, Article 3817 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

ZHENFENG ZHANG ; JAE CHEOL LEE ; YUN JUNG CHOI ; CHOI, Chang-Min ; KIM, Sang-We ; SE JIN JANG ; YOUNG SOO PARK ; WOO SUNG KIM ; DAE HO LEE ; LEE, Jung-Shin ; MILLER, Vincent A ; ARCILA, Maria ; LUPING LIN ; LADANYI, Marc ; MOONSAMY, Philicia ; SAWYERS, Charles ; BOGGON, Titus J ; MA, Patrick C ; COSTA, Carlota ; TARON, Miquel ; ROSELL, Rafael ; HALMOS, Balazs ; BIVONA, Treverg ; OLIVAS, Victor ; AU, Valerie ; LAFRAMBOISE, Thomas ; ABDEL-RAHMAN, Mohamed ; XIAOQI WANG ; LEVINE, Alan D ; JIN KYUNG RHO

Nature genetics, 2012-08, Vol.44 (8), p.852-860 [Periódico revisado por pares]

New York, NY: Nature Publishing Group

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7
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

Duncan, James S. ; Whittle, Martin C. ; Nakamura, Kazuhiro ; Abell, Amy N. ; Midland, Alicia A. ; Zawistowski, Jon S. ; Johnson, Nancy L. ; Granger, Deborah A. ; Jordan, Nicole Vincent ; Darr, David B. ; Usary, Jerry ; Kuan, Pei-Fen ; Smalley, David M. ; Major, Ben ; He, Xiaping ; Hoadley, Katherine A. ; Zhou, Bing ; Sharpless, Norman E. ; Perou, Charles M. ; Kim, William Y. ; Gomez, Shawn M. ; Chen, Xin ; Jin, Jian ; Frye, Stephen V. ; Earp, H. Shelton ; Graves, Lee M. ; Johnson, Gary L.

Cell, 2012-04, Vol.149 (2), p.307-321 [Periódico revisado por pares]

United States: Elsevier Inc

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8
Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited
Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited
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Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

Potapova, Tamara A ; Sivakumar, Sushama ; Flynn, Jennifer N ; Li, Rong ; Gorbsky, Gary J Solomon, Mark J.

Molecular biology of the cell, 2011-04, Vol.22 (8), p.1191-1206 [Periódico revisado por pares]

United States: The American Society for Cell Biology

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9
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
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MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

Triantafyllou, Evangelos ; Pop, Oltin T ; Possamai, Lucia A ; Wilhelm, Annika ; Liaskou, Evaggelia ; Singanayagam, Arjuna ; Bernsmeier, Christine ; Khamri, Wafa ; Petts, Gemma ; Dargue, Rebecca ; Davies, Scott P ; Tickle, Joseph ; Yuksel, Muhammed ; Patel, Vishal C ; Abeles, Robin D ; Stamataki, Zania ; Curbishley, Stuart M ; Ma, Yun ; Wilson, Ian D ; Coen, Muireann ; Woollard, Kevin J ; Quaglia, Alberto ; Wendon, Julia ; Thursz, Mark R ; Adams, David H ; Weston, Chris J ; Antoniades, Charalambos G

Gut, 2018-02, Vol.67 (2), p.333-347 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

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10
Prolonged and tunable residence time using reversible covalent kinase inhibitors
Prolonged and tunable residence time using reversible covalent kinase inhibitors
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Prolonged and tunable residence time using reversible covalent kinase inhibitors

Bradshaw, J Michael ; McFarland, Jesse M ; Paavilainen, Ville O ; Bisconte, Angelina ; Tam, Danny ; Phan, Vernon T ; Romanov, Sergei ; Finkle, David ; Shu, Jin ; Patel, Vaishali ; Ton, Tony ; Li, Xiaoyan ; Loughhead, David G ; Nunn, Philip A ; Karr, Dane E ; Gerritsen, Mary E ; Funk, Jens Oliver ; Owens, Timothy D ; Verner, Erik ; Brameld, Ken A ; Hill, Ronald J ; Goldstein, David M ; Taunton, Jack

Nature chemical biology, 2015-07, Vol.11 (7), p.525-531 [Periódico revisado por pares]

United States: Nature Publishing Group

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