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Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
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Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Vangeel, Laura ; Chiu, Winston ; De Jonghe, Steven ; Maes, Piet ; Slechten, Bram ; Raymenants, Joren ; André, Emmanuel ; Leyssen, Pieter ; Neyts, Johan ; Jochmans, Dirk

Antiviral research, 2022-02, Vol.198, p.105252-105252, Article 105252 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Hundreds of COVID trials could provide a deluge of new drugs
Hundreds of COVID trials could provide a deluge of new drugs
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Hundreds of COVID trials could provide a deluge of new drugs

Ledford, Heidi

Nature (London), 2022-03, Vol.603 (7899), p.25-27 [Periódico revisado por pares]

England

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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Owen, Dafydd R ; Allerton, Charlotte M N ; Anderson, Annaliesa S ; Aschenbrenner, Lisa ; Avery, Melissa ; Berritt, Simon ; Boras, Britton ; Cardin, Rhonda D ; Carlo, Anthony ; Coffman, Karen J ; Dantonio, Alyssa ; Di, Li ; Eng, Heather ; Ferre, RoseAnn ; Gajiwala, Ketan S ; Gibson, Scott A ; Greasley, Samantha E ; Hurst, Brett L ; Kadar, Eugene P ; Kalgutkar, Amit S ; Lee, Jack C ; Lee, Jisun ; Liu, Wei ; Mason, Stephen W ; Noell, Stephen ; Novak, Jonathan J ; Obach, R Scott ; Ogilvie, Kevin ; Patel, Nandini C ; Pettersson, Martin ; Rai, Devendra K ; Reese, Matthew R ; Sammons, Matthew F ; Sathish, Jean G ; Singh, Ravi Shankar P ; Steppan, Claire M ; Stewart, Al E ; Tuttle, Jamison B ; Updyke, Lawrence ; Verhoest, Patrick R ; Wei, Liuqing ; Yang, Qingyi ; Zhu, Yuao

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1586-1593 [Periódico revisado por pares]

United States

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An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19
An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19
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An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19

Singh, Awadhesh Kumar ; Singh, Akriti ; Singh, Ritu ; Misra, Anoop

Diabetes & metabolic syndrome clinical research & reviews, 2022-02, Vol.16 (2), p.102396-102396, Article 102396 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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5
l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells
l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells
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l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells

Li, Huiying ; Li, Songli ; Yang, Huaigu ; Wang, Yizhen ; Wang, Jiaqi ; Zheng, Nan

Toxins, 2019-04, Vol.11 (4), p.226 [Periódico revisado por pares]

Switzerland: MDPI AG

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6
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers
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ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers

Jing, Na ; Zhang, Kai ; Chen, Xinyu ; Liu, Kaiyuan ; Wang, Jinming ; Xiao, Lingling ; Zhang, Wentian ; Ma, Pengfei ; Xu, Penghui ; Cheng, Chaping ; Wang, Deng ; Zhao, Huifang ; He, Yuman ; Ji, Zhongzhong ; Xin, Zhixiang ; Sun, Yujiao ; Zhang, Yingchao ; Bao, Wei ; Gong, Yiming ; Fan, Liancheng ; Ji, Yiyi ; Zhuang, Guanglei ; Wang, Qi ; Dong, Baijun ; Zhang, Pengcheng ; Xue, Wei ; Gao, Wei-Qiang ; Zhu, Helen He

The Journal of clinical investigation, 2023-12, Vol.133 (24), p.1-18 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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7
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation
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Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation

Wang, Jiacheng ; Xue, Zhimin ; Lin, Jun ; Wang, Yao ; Ying, Hangying ; Lv, Qingbo ; Hua, Chunting ; Wang, Meihui ; Chen, Siji ; Zhou, Binquan

Biochemical pharmacology, 2020-08, Vol.178, p.114065-114065, Article 114065 [Periódico revisado por pares]

England: Elsevier Inc

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8
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain
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Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

Deuis, Jennifer R ; Wingerd, Joshua S ; Winter, Zoltan ; Durek, Thomas ; Dekan, Zoltan ; Sousa, Silmara R ; Zimmermann, Katharina ; Hoffmann, Tali ; Weidner, Christian ; Nassar, Mohammed A ; Alewood, Paul F ; Lewis, Richard J ; Vetter, Irina

Toxins, 2016-03, Vol.8 (3), p.78 [Periódico revisado por pares]

Switzerland: MDPI

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9
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
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The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

Savolainen, Mari H ; Richie, Christopher T ; Harvey, Brandon K ; Männistö, Pekka T ; Maguire-Zeiss, Kathleen A ; Myöhänen, Timo T

Neurobiology of disease, 2014-08, Vol.68, p.1-15 [Periódico revisado por pares]

United States: Elsevier Inc

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10
Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Njoroge, F. George ; Chen, Kevin X ; Shih, Neng-Yang ; Piwinski, John J

Accounts of chemical research, 2008-01, Vol.41 (1), p.50-59 [Periódico revisado por pares]

United States: American Chemical Society

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