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1
Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization
Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization
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Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

Osgerby, Laura ; Lai, Yu-Chiang ; Thornton, Peter J ; Amalfitano, Joseph ; Le Duff, Cécile S ; Jabeen, Iqra ; Kadri, Hachemi ; Miccoli, Ageo ; Tucker, James H. R ; Muqit, Miratul M. K ; Mehellou, Youcef

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3518-3524 [Periódico revisado por pares]

United States: American Chemical Society

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2
Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology
Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology
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Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

Nitsche, Christoph ; Zhang, Linlin ; Weigel, Lena F ; Schilz, Jonas ; Graf, Dominik ; Bartenschlager, Ralf ; Hilgenfeld, Rolf ; Klein, Christian D

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.511-516 [Periódico revisado por pares]

United States: American Chemical Society

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3
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction
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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction

Blevitt, Jonathan M ; Hack, Michael D ; Herman, Krystal L ; Jackson, Paul F ; Krawczuk, Paul J ; Lebsack, Alec D ; Liu, Annie X ; Mirzadegan, Taraneh ; Nelen, Marina I ; Patrick, Aaron N ; Steinbacher, Stefan ; Milla, Marcos E ; Lumb, Kevin J

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3511-3517 [Periódico revisado por pares]

United States: American Chemical Society

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4
Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability
Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability
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Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability

Zhao, Tong ; Meng, Qing ; Sun, Zhuosen ; Chen, Yanyu ; Ai, Wei ; Zhao, Zean ; Kang, Dongwei ; Dong, Yue ; Liang, Ruipeng ; Wu, Ting ; Pang, Jianxin ; Liu, Xinyong ; Zhan, Peng

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10829-10854 [Periódico revisado por pares]

United States: American Chemical Society

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5
Structure–Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis
Structure–Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis
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Structure–Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis

Garrison, Aaron T ; Abouelhassan, Yasmeen ; Norwood, Verrill M ; Kallifidas, Dimitris ; Bai, Fang ; Nguyen, Minh Thu ; Rolfe, Melanie ; Burch, Gena M ; Jin, Shouguang ; Luesch, Hendrik ; Huigens, Robert W

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3808-3825 [Periódico revisado por pares]

United States: American Chemical Society

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6
Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase
Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase
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Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase

Ng, Hui-Li ; Ma, Xiang ; Chew, Eng-Hui ; Chui, Wai-Keung

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1734-1745 [Periódico revisado por pares]

United States: American Chemical Society

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7
Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators
Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators
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Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators

Keune, Willem-Jan ; Potjewyd, Frances ; Heidebrecht, Tatjana ; Salgado-Polo, Fernando ; Macdonald, Simon J. F ; Chelvarajan, Lakshman ; Abdel Latif, Ahmed ; Soman, Sony ; Morris, Andrew J ; Watson, Allan J. B ; Jamieson, Craig ; Perrakis, Anastassis

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.2006-2017 [Periódico revisado por pares]

United States: American Chemical Society

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8
Thieno[2,3‑d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)
Thieno[2,3‑d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)
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Thieno[2,3‑d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)

Berhane, Ilyas ; Hin, Niyada ; Thomas, Ajit G ; Huang, Qian ; Zhang, Chi ; Veeravalli, Vijayabhaskar ; Wu, Ying ; Ng, Justin ; Alt, Jesse ; Rojas, Camilo ; Hihara, Hiroe ; Aoki, Mika ; Yoshizawa, Kyoko ; Nishioka, Tomoki ; Suzuki, Shuichi ; He, Shao-Qiu ; Peng, Qi ; Guan, Yun ; Dong, Xinzhong ; Raja, Srinivasa N ; Slusher, Barbara S ; Rais, Rana ; Tsukamoto, Takashi

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3218-3228 [Periódico revisado por pares]

United States: American Chemical Society

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9
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis
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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

Hong, W. David ; Gibbons, Peter D ; Leung, Suet C ; Amewu, Richard ; Stocks, Paul A ; Stachulski, Andrew ; Horta, Pedro ; Cristiano, Maria L. S ; Shone, Alison E ; Moss, Darren ; Ardrey, Alison ; Sharma, Raman ; Warman, Ashley J ; Bedingfield, Paul T. P ; Fisher, Nicholas E ; Aljayyoussi, Ghaith ; Mead, Sally ; Caws, Maxine ; Berry, Neil G ; Ward, Stephen A ; Biagini, Giancarlo A ; O’Neill, Paul M ; Nixon, Gemma L

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3703-3726 [Periódico revisado por pares]

United States: American Chemical Society

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10
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Cheeseman, Matthew D ; Chessum, Nicola E. A ; Rye, Carl S ; Pasqua, A. Elisa ; Tucker, Michael J ; Wilding, Birgit ; Evans, Lindsay E ; Lepri, Susan ; Richards, Meirion ; Sharp, Swee Y ; Ali, Salyha ; Rowlands, Martin ; O’Fee, Lisa ; Miah, Asadh ; Hayes, Angela ; Henley, Alan T ; Powers, Marissa ; te Poele, Robert ; De Billy, Emmanuel ; Pellegrino, Loredana ; Raynaud, Florence ; Burke, Rosemary ; van Montfort, Rob L. M ; Eccles, Suzanne A ; Workman, Paul ; Jones, Keith

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.180-201 [Periódico revisado por pares]

United States: American Chemical Society

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