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1
HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents
HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents
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HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents

Karoline de Barros Waitman Larissa Costa de Almeida; Marina Candido Primi; Jorge Antonio Elias Godoy Carlos; Claudia Ruiz; Thales Kronenberger; Stefan Laufer; Marcia Ines Goettert; Antti Poso; Sandra Valeria Vassiliades; Vinicius Albuquerque Moreira de Souza; Mônica Franco Zannini Junqueira Toledo; Neuza Mariko Aymoto Hassimotto; Michael D Cameron; Thomas D Bannister; Letícia Veras Costa-Lotufo; João Agostinho Machado Neto; Maurício T Tavares; Roberto Parise Filho

European Journal of Medicinal Chemistry Issy-Les-Moulineaux v. 263, p. 1-18 art. 115935, 2024

Issy-Les-Moulineaux 2024

Item não circula. Consulte sua biblioteca.(Acessar)

2
Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: synthesis and muscarinic activity
Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: synthesis and muscarinic activity
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Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: synthesis and muscarinic activity

Dannhardt, G ; Kiefer, W ; Lambrecht, G ; Laufer, S ; Mutschler, E ; Schweiger, J ; Striegel, H.G.

European journal of medicinal chemistry, 1995, Vol.30 (11), p.839-850 [Periódico revisado por pares]

Oxford: Elsevier Masson SAS

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3
Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration
Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration
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Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration

Pfaffenrot, Bent ; Klövekorn, Philip ; Juchum, Michael ; Selig, Roland ; Albrecht, Wolfgang ; Zender, Lars ; Laufer, Stefan A.

European journal of medicinal chemistry, 2021-06, Vol.218, p.113371-113371, Article 113371 [Periódico revisado por pares]

France: Elsevier Masson SAS

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4
Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors
Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors
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Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors

Juchum, Michael ; Pfaffenrot, Bent ; Klövekorn, Philip ; Selig, Roland ; Albrecht, Wolfgang ; Zender, Lars ; Laufer, Stefan A.

European journal of medicinal chemistry, 2022-10, Vol.240, p.114584-114584, Article 114584 [Periódico revisado por pares]

Elsevier Masson SAS

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5
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)
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From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

Klövekorn, Philip ; Pfaffenrot, Bent ; Juchum, Michael ; Selig, Roland ; Albrecht, Wolfgang ; Zender, Lars ; Laufer, Stefan A.

European journal of medicinal chemistry, 2021-01, Vol.210, p.112963-112963, Article 112963 [Periódico revisado por pares]

France: Elsevier Masson SAS

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6
Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
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Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors

Heider, Fabian ; Ansideri, Francesco ; Tesch, Roberta ; Pantsar, Tatu ; Haun, Urs ; Döring, Eva ; Kudolo, Mark ; Poso, Antti ; Albrecht, Wolfgang ; Laufer, Stefan A. ; Koch, Pierre

European journal of medicinal chemistry, 2019-08, Vol.175, p.309-329 [Periódico revisado por pares]

France: Elsevier Masson SAS

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7
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
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Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia de Castro ; Lima, Lídia Moreira ; Tesch, Roberta ; Sant'Anna, Carlos Mauricio R. ; Totzke, Frank ; Kubbutat, Michael H.G. ; Schächtele, Christoph ; Laufer, Stefan A. ; Barreiro, Eliezer J.

European journal of medicinal chemistry, 2014-01, Vol.71, p.1-14 [Periódico revisado por pares]

France: Elsevier Masson SAS

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8
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation
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Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation

Astolfi, Andrea ; Kudolo, Mark ; Brea, Jose ; Manni, Giorgia ; Manfroni, Giuseppe ; Palazzotti, Deborah ; Sabatini, Stefano ; Cecchetti, Federica ; Felicetti, Tommaso ; Cannalire, Rolando ; Massari, Serena ; Tabarrini, Oriana ; Loza, Maria Isabel ; Fallarino, Francesca ; Cecchetti, Violetta ; Laufer, Stefan A. ; Barreca, Maria Letizia

European journal of medicinal chemistry, 2019-11, Vol.182, p.111624-111624, Article 111624 [Periódico revisado por pares]

France: Elsevier Masson SAS

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9
Identifying representative kinases for inhibitor evaluation via systematic analysis of compound-based target relationships
Identifying representative kinases for inhibitor evaluation via systematic analysis of compound-based target relationships
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Identifying representative kinases for inhibitor evaluation via systematic analysis of compound-based target relationships

Laufkötter, Oliver ; Laufer, Stefan ; Bajorath, Jürgen

European journal of medicinal chemistry, 2020-10, Vol.204, p.112641-112641, Article 112641 [Periódico revisado por pares]

Elsevier Masson SAS

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10
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation
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NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation

Blaess, Markus ; Bibak, Nelly ; Claus, Ralf A. ; Kohl, Matthias ; Bonaterra, Gabriel A. ; Kinscherf, Ralf ; Laufer, Stefan ; Deigner, Hans-Peter

European journal of medicinal chemistry, 2018-06, Vol.153, p.73-104 [Periódico revisado por pares]

France: Elsevier Masson SAS

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