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Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
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Small molecules, big targets: drug discovery faces the protein-protein interaction challenge

Scott, Duncan E ; Bayly, Andrew R ; Abell, Chris ; Skidmore, John

Nature reviews. Drug discovery, 2016-08, Vol.15 (8), p.533-550 [Periódico revisado por pares]

England: Nature Publishing Group

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12
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

Duncan, James S. ; Whittle, Martin C. ; Nakamura, Kazuhiro ; Abell, Amy N. ; Midland, Alicia A. ; Zawistowski, Jon S. ; Johnson, Nancy L. ; Granger, Deborah A. ; Jordan, Nicole Vincent ; Darr, David B. ; Usary, Jerry ; Kuan, Pei-Fen ; Smalley, David M. ; Major, Ben ; He, Xiaping ; Hoadley, Katherine A. ; Zhou, Bing ; Sharpless, Norman E. ; Perou, Charles M. ; Kim, William Y. ; Gomez, Shawn M. ; Chen, Xin ; Jin, Jian ; Frye, Stephen V. ; Earp, H. Shelton ; Graves, Lee M. ; Johnson, Gary L.

Cell, 2012-04, Vol.149 (2), p.307-321 [Periódico revisado por pares]

United States: Elsevier Inc

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13
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury
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Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury

Li, Tao ; Zhang, Zhen ; Kolwicz, Stephen C. ; Abell, Lauren ; Roe, Nathan D. ; Kim, Maengjo ; Zhou, Bo ; Cao, Yang ; Ritterhoff, Julia ; Gu, Haiwei ; Raftery, Daniel ; Sun, Haipeng ; Tian, Rong

Cell metabolism, 2017-02, Vol.25 (2), p.374-385 [Periódico revisado por pares]

United States: Elsevier Inc

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14
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2
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Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2

Volkmar, Norbert ; Gawden‐Bone, Christian M ; Williamson, James C ; Nixon‐Abell, Jonathon ; West, James A ; St George‐Hyslop, Peter H ; Kaser, Arthur ; Lehner, Paul J

The EMBO journal, 2022-10, Vol.41 (19), p.e110777-n/a [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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15
ER proteins decipher the tubulin code to regulate organelle distribution
ER proteins decipher the tubulin code to regulate organelle distribution
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ER proteins decipher the tubulin code to regulate organelle distribution

Zheng, Pengli ; Obara, Christopher J ; Szczesna, Ewa ; Nixon-Abell, Jonathon ; Mahalingan, Kishore K ; Roll-Mecak, Antonina ; Lippincott-Schwartz, Jennifer ; Blackstone, Craig

Nature (London), 2022-01, Vol.601 (7891), p.132-138 [Periódico revisado por pares]

England: Nature Publishing Group

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16
MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
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MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells

Abell, Amy N. ; Jordan, Nicole Vincent ; Huang, Weichun ; Prat, Aleix ; Midland, Alicia A. ; Johnson, Nancy L. ; Granger, Deborah A. ; Mieczkowski, Piotr A. ; Perou, Charles M. ; Gomez, Shawn M. ; Li, Leping ; Johnson, Gary L.

Cell stem cell, 2011-05, Vol.8 (5), p.525-537 [Periódico revisado por pares]

Cambridge, MA: Elsevier Inc

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17
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
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Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER

Nixon-Abell, Jonathon ; Obara, Christopher J. ; Weigel, Aubrey V. ; Li, Dong ; Legant, Wesley R. ; Xu, C. Shan ; Pasolli, H. Amalia ; Harvey, Kirsten ; Hess, Harald F. ; Betzig, Eric ; Blackstone, Craig ; Lippincott-Schwartz, Jennifer

Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6311), p.433-433 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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18
The freshwater biodiversity crisis
The freshwater biodiversity crisis
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The freshwater biodiversity crisis

Harrison, Ian ; Abell, Robin ; Darwall, William ; Thieme, Michele L ; Tickner, David ; Timboe, Ingrid Sills, Jennifer

Science (American Association for the Advancement of Science), 2018-12, Vol.362 (6421), p.1369-1369 [Periódico revisado por pares]

United States

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19
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Pellegrini, Laura ; Hauser, David N ; Li, Yan ; Mamais, Adamantios ; Beilina, Alexandra ; Kumaran, Ravindran ; Wetzel, Andrea ; Nixon-Abell, Jonathon ; Heaton, George ; Rudenko, Iakov ; Alkaslasi, Mor ; Ivanina, Natalie ; Melrose, Heather L ; Cookson, Mark R ; Harvey, Kirsten

Human molecular genetics, 2018-09, Vol.27 (18), p.3257-3271 [Periódico revisado por pares]

England: Oxford University Press

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20
Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow
Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow
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Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow

Olatunde, Adesola C ; Abell, Laura P ; Landuyt, Ashley E ; Hiltbold Schwartz, Elizabeth Mattei, Fabrizio

PloS one, 2018-05, Vol.13 (5), p.e0196591-e0196591 [Periódico revisado por pares]

United States: Public Library of Science

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