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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Mice remover Medical Sciences remover
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1
Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model
Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model
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Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Yue, Eddy W ; Douty, Brent ; Wayland, Brian ; Bower, Michael ; Liu, Xiangdong ; Leffet, Lynn ; Wang, Qian ; Bowman, Kevin J ; Hansbury, Michael J ; Liu, Changnian ; Wei, Min ; Li, Yanlong ; Wynn, Richard ; Burn, Timothy C ; Koblish, Holly K ; Fridman, Jordan S ; Metcalf, Brian ; Scherle, Peggy A ; Combs, Andrew P

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7364-7367 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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2
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles
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Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

Bakunov, Stanislav A ; Bakunova, Svetlana M ; Wenzler, Tanja ; Ghebru, Maedot ; Werbovetz, Karl A ; Brun, Reto ; Tidwell, Richard R

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.254-272 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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3
Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)
Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)
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Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

Flatt, Brenton ; Martin, Richard ; Wang, Tie-Lin ; Mahaney, Paige ; Murphy, Brett ; Gu, Xiao-Hui ; Foster, Paul ; Li, Jiali ; Pircher, Parinaz ; Petrowski, Mary ; Schulman, Ira ; Westin, Stefan ; Wrobel, Jay ; Yan, Grace ; Bischoff, Eric ; Daige, Chris ; Mohan, Raju

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.904-907 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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4
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Menear, Keith A ; Adcock, Claire ; Boulter, Robert ; Cockcroft, Xiao-ling ; Copsey, Louise ; Cranston, Aaron ; Dillon, Krystyna J ; Drzewiecki, Jan ; Garman, Sheila ; Gomez, Sylvie ; Javaid, Hashim ; Kerrigan, Frank ; Knights, Charlotte ; Lau, Alan ; Loh, Vincent M ; Matthews, Ian T. W ; Moore, Stephen ; O’Connor, Mark J ; Smith, Graeme C. M ; Martin, Niall M. B

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6581-6591 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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5
Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity
Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity
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Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Howard, Steven ; Berdini, Valerio ; Boulstridge, John A ; Carr, Maria G ; Cross, David M ; Curry, Jayne ; Devine, Lindsay A ; Early, Theresa R ; Fazal, Lynsey ; Gill, Adrian L ; Heathcote, Michelle ; Maman, Sarita ; Matthews, Julia E ; McMenamin, Rachel L ; Navarro, Eva F ; O’Brien, Michael A ; O’Reilly, Marc ; Rees, David C ; Reule, Matthias ; Tisi, Dominic ; Williams, Glyn ; Vinković, Mladen ; Wyatt, Paul G

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.379-388 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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6
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
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Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Verhoest, Patrick R ; Proulx-Lafrance, Caroline ; Corman, Michael ; Chenard, Lois ; Helal, Christopher J ; Hou, Xinjun ; Kleiman, Robin ; Liu, Shenping ; Marr, Eric ; Menniti, Frank S ; Schmidt, Christopher J ; Vanase-Frawley, Michelle ; Schmidt, Anne W ; Williams, Robert D ; Nelson, Frederick R ; Fonseca, Kari R ; Liras, Spiros

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7946-7949 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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7
Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β Ligands
Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β Ligands
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Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β Ligands

Malamas, Michael S ; Manas, Eric S ; McDevitt, Robert E ; Gunawan, Iwan ; Xu, Zhang B ; Collini, Michael D ; Miller, Chris P ; Dinh, Tam ; Henderson, Ruth A ; Keith, James C ; Harris, Heather A

Journal of medicinal chemistry, 2004-10, Vol.47 (21), p.5021-5040 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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8
Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
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Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Seth, Punit P ; Siwkowski, Andrew ; Allerson, Charles R ; Vasquez, Guillermo ; Lee, Sam ; Prakash, Thazha P ; Wancewicz, Edward V ; Witchell, Donna ; Swayze, Eric E

Journal of medicinal chemistry, 2009-01, Vol.52 (1), p.10-13 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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9
Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes
Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes
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Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes

Genet, Cédric ; Strehle, Axelle ; Schmidt, Céline ; Boudjelal, Geoffrey ; Lobstein, Annelise ; Schoonjans, Kristina ; Souchet, Michel ; Auwerx, Johan ; Saladin, Régis ; Wagner, Alain

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.178-190 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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10
Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model
Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model
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Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model

Tradtrantip, Lukmanee ; Sonawane, N. D ; Namkung, Wan ; Verkman, A. S

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6447-6455 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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