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Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects
Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects
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Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects

Zhu, Yuankui ; Wang, Ke ; Yue, Linghe ; Zuo, Dianbao ; Sheng, Junfeng ; Lan, Sina ; Zhao, Zilong ; Dong, Shuang ; Hu, Sheng ; Chen, Xin ; Feng, Mingqian

Pharmacological research, 2024-05, Vol.203, p.107186-107186, Article 107186 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III
Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III
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Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III

Schröder, Jutta ; Moll, Jens M ; Baran, Paul ; Grötzinger, Joachim ; Scheller, Jürgen ; Floss, Doreen M

The Journal of biological chemistry, 2015-01, Vol.290 (1), p.359-370 [Periódico revisado por pares]

United States: American Society for Biochemistry and Molecular Biology

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3
Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing
Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing
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Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing

Akbar, Noor ul ; Ahmad, Sajjad ; Khan, Taj Ali ; Tayyeb, Muhammad ; Akhter, Naheed ; Shafiq, Laraib ; Khan, Shahid Niaz ; Alam, Mohammad Mahtab ; Abdullah, Alduwish Manal ; Rehman, Muhammad Fayyaz ur ; Bajaber, Majed A. ; Akram, Muhammad Safwan

Infection, genetics and evolution, 2024-03, Vol.118, p.105559-105559, Article 105559 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction
Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction
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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Georgy, Jacqueline ; Arlt, Yvonne ; Moll, Jens M. ; Ouzin, Meryem ; Weitz, Hendrik T. ; Gremer, Lothar ; Willbold, Dieter ; Grötzinger, Joachim ; Thives-Kurenbach, Felix ; Scheller, Jürgen ; Floss, Doreen M.

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101295-101295, Article 101295 [Periódico revisado por pares]

United States: Elsevier Inc

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5
Cure of syngeneic carcinomas with targeted IL-12 through obligate reprogramming of lymphoid and myeloid immunity
Cure of syngeneic carcinomas with targeted IL-12 through obligate reprogramming of lymphoid and myeloid immunity
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Cure of syngeneic carcinomas with targeted IL-12 through obligate reprogramming of lymphoid and myeloid immunity

Hong, Youji ; Robbins, Yvette ; Yang, Xinping ; Mydlarz, Wojciech K ; Sowers, Anastasia ; Mitchell, James B ; Gulley, James L ; Schlom, Jeffrey ; Gameiro, Sofia R ; Sievers, Cem ; Allen, Clint T

JCI insight, 2022-03, Vol.7 (5) [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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6
Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors
Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors
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Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors

Esch, Alessandra ; Masiarz, Anna ; Mossner, Sofie ; Moll, Jens M. ; Grötzinger, Joachim ; Schröder, Jutta ; Scheller, Jürgen ; Floss, Doreen M.

The Journal of biological chemistry, 2020-07, Vol.295 (30), p.10478-10492 [Periódico revisado por pares]

United States: Elsevier Inc

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7
Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses
Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses
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Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses

Sela, Uri ; Park, Chae Gyu ; Park, Andrew ; Olds, Peter ; Wang, Shu ; Steinman, Ralph M ; Fischetti, Vincent A Unutmaz, Derya

PloS one, 2016, Vol.11 (1), p.e0146412-e0146412 [Periódico revisado por pares]

United States: Public Library of Science

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8
A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production
A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production
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A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

Nakajima, Toshiki ; Yoshifuji, Hajime ; Shimizu, Masakazu ; Kitagori, Koji ; Murakami, Kosaku ; Nakashima, Ran ; Imura, Yoshitaka ; Tanaka, Masao ; Ohmura, Koichiro ; Matsuda, Fumihiko ; Terao, Chikashi ; Mimori, Tsuneyo

Arthritis research & therapy, 2017-09, Vol.19 (1), p.197-197, Article 197 [Periódico revisado por pares]

England: BioMed Central Ltd

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9
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease
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Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease

Nabhani, Schafiq ; Ginzel, Sebastian ; Miskin, Hagit ; Revel-Vilk, Shoshana ; Harlev, Dan ; Fleckenstein, Bernhard ; Hönscheid, Andrea ; Oommen, Prasad T ; Kuhlen, Michaela ; Thiele, Ralf ; Laws, Hans-Jürgen ; Borkhardt, Arndt ; Stepensky, Polina ; Fischer, Ute

Haematologica (Roma), 2015-09, Vol.100 (9), p.1189-1198 [Periódico revisado por pares]

Italy: Ferrata Storti Foundation

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10
Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice
Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice
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Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice

Eede, Pascale ; Obst, Juliane ; Benke, Eileen ; Yvon‐Durocher, Genevieve ; Richard, Bernhard C ; Gimber, Niclas ; Schmoranzer, Jan ; Böddrich, Annett ; Wanker, Erich E ; Prokop, Stefan ; Heppner, Frank L

EMBO reports, 2020-03, Vol.21 (3), p.e48530-n/a [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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