Preliminary results from a phase 1/2 study of co-stimulatory bispecific PSMAxCD28 antibody REGN5678 in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Stein, Mark N. ; Zhang, Jingsong ; Kelly, William Kevin ; Wise, David R ; Tsao, Kai ; Carneiro, Benedito A. ; Falchook, Gerald Steven ; Sun, Furong ; Govindraj, Shilpa ; Sims, Jennifer S ; Zhu, Min ; Seebach, Frank A. ; Lowy, Israel ; Thanigaimani, Pradeep ; Sandigursky, Sabina ; Miller, Elizabeth

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A phase 1/2 study of REGN7075 (EGFRxCD28 costimulatory bispecific antibody) in combination with cemiplimab (anti–PD-1) in patients with advanced solid tumors: Trial-in-progress update

Segal, Neil Howard ; Pelster, Meredith ; Girda, Eugenia ; Fong, Lawrence ; Olszanski, Anthony J. ; Han, Hyunsil ; Casey, Kerry A. ; Li, Siyu ; Welf, Erik ; Chen, Chieh-I ; Skokos, Dimitris ; Seebach, Frank A. ; Lowy, Israel ; Fury, Matthew G. ; Mathias, Melissa Divya ; Lakhani, Nehal J.

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A phase 1/2 study of REGN7075 in combination with cemiplimab (cemi) in patients (pts) with advanced solid tumors: Efficacy and safety results

Segal, Neil Howard ; Girda, Eugenia ; Sohal, Davendra ; Lakhani, Nehal J. ; Olszanski, Anthony J. ; Fong, Lawrence ; Kinnaman, Michael David ; Han, Hyunsil ; Skokos, Dimitris ; Casey, Kerry A. ; Wang, JuAn ; Wang, Bei ; Hao, Yi ; Li, Siyu ; Ganguly, Samit ; Lowy, Israel ; Seebach, Frank A. ; Mathias, Melissa Divya ; Johnson, Melissa Lynne

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Combination of cemiplimab and ISA101b vaccine for the treatment of recurrent/metastatic HPV16 cervical cancer

Lorusso, Domenica ; Oaknin, Ana ; Santos Borges, Giuliano ; Damian, Fernanda ; Ottevanger, P. B. ; Van Gorp, Toon ; Paiva, Carlos Eduardo ; Kroep, Judith R. ; Kim, Yong Man ; Kim, Hee Seung ; Lee, Jae-Kwan ; Melief, Cornelis JM ; Hooftman, Leon ; Jamil, Shaheda Jamil ; Yoo, Suk-Young ; Seebach, Frank A. ; Lowy, Israel ; Fury, Matthew G. ; Mathias, Melissa Divya ; Colombo, Nicoletta

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A phase I/II study of REGN5678 (Anti-PSMAxCD28, a costimulatory bispecific antibody) with cemiplimab (anti–PD-1) in patients with metastatic castration-resistant prostate cancer

Zhang, Jingsong ; Stein, Mark N. ; Kelly, William Kevin ; Tsao, Che-Kai ; Falchook, Gerald Steven ; Xu, Yuanfang ; Seebach, Frank A. ; Lowy, Israel ; Mohan, Kosalai Kal ; Kroog, Glenn ; Miller, Elizabeth

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A phase 1/2 study of REGN5093-M114, a METxMET antibody-drug conjugate, in patients with mesenchymal epithelial transition factor (MET)-overexpressing NSCLC

Drilon, Alexander E. ; Awad, Mark M. ; Gadgeel, Shirish M. ; Villaruz, Liza C ; Sabari, Joshua K. ; Perez, Javier ; Daly, Christopher ; Patel, Shraddha ; Li, Siyu ; Seebach, Frank A. ; Lowy, Israel ; Magnan, Heather D. ; Rietschel, Petra

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Peripheral myeloid cells as prognostic markers in patients (pts) with non-small cell lung cancer (NSCLC) treated with cemiplimab: Pooled analysis of EMPOWER-Lung 1 and EMPOWER-Lung 3 phase 3 trials

Murray, Joseph Christopher ; McIntyre, Debra AG ; Anagnostou, Valsamo ; Brahmer, Julie R. ; Meisel, Alexander ; Sezer, Ahmet ; Gogishvili, Miranda ; Melkadze, Tamar ; Baramidze, Ana ; Makharadze, Tamta ; He, Adam ; Li, Siyu ; Jankovic, Vladimir ; Seebach, Frank A. ; Rietschel, Petra ; Kim, Young J. ; Gullo, Giuseppe ; Pouliot, Jean-Francois

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A phase I/II study of REGN5678 (Anti-PSMAxCD28, a costimulatory bispecific antibody) with cemiplimab (anti-PD-1) in patients with metastatic castration-resistant prostate cancer

Drake, Charles G. ; Zhang, Jingsong ; Stein, Mark N. ; Xu, Yuanfang ; Seebach, Frank A. ; Lowy, Israel ; Mohan, Kosalai Kal ; Kroog, Glenn ; Miller, Elizabeth

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Phase 2 open-label, multicenter, single-arm study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Extended follow-up

Stratigos, Alexander J. ; Sekulic, Aleksandar ; Peris, Ketty ; Bechter, Oliver ; Prey, Sorilla ; Lewis, Karl D. ; Basset-Seguin, Nicole ; Chang, Anne Lynn S. ; Dalle, Stéphane ; Fernández Orland, Almudena ; Licitra, Lisa ; Robert, Caroline ; Ulrich, Claas ; Hauschild, Axel ; Migden, Michael R. ; Dummer, Reinhard ; Yoo, Suk-Young ; Okoye, Emmanuel ; Bassukas, Ioannis ; Loquai, Carmen ; De Giorgi, Vincenzo ; Eroglu, Zeynep ; Gutzmer, Ralf ; Ulrich, Jens ; Puig, Susana ; Inocencio, Timothy J. ; Chen, Chieh-I ; LaFontaine, Patrick R. ; Seebach, Frank ; Lowy, Israel ; Fury, Matthew G.

United States: Elsevier Inc

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Cemiplimab monotherapy as first-line (1L) treatment of patients with brain metastases from advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) ≥ 50%: EMPOWER-Lung 1 subgroup analysis

Ozguroglu, Mustafa ; Sezer, Ahmet ; Kilickap, Saadettin ; Gumus, Mahmut ; Bondarenko, Igor ; Gogishvili, Miranda ; Turk, Haci M. ; Cicin, Irfan ; Bentsion, Dmitry ; Gladkov, Oleg ; Clingan, Philip R. ; Sriuranpong, Virote ; Rizvi, Naiyer A. ; McGinniss, Jennifer ; Pouliot, Jean-Francois ; Lee, Sue ; Seebach, Frank A. ; Lowy, Israel ; Gullo, Giuseppe ; Rietschel, Petra

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