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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

KOPPIKAR, Priya ; BHAGWAT, Neha ; LEUNG, Laura ; WEINSTEIN, Abby ; MARUBAYASHI, Sachie ; GOEL, Aviva ; GÖNEN, Mithat ; ESTROV, Zeev ; EBERT, Benjamin L ; CHIOSIS, Gabriela ; NIMER, Stephen D ; BERNSTEIN, Bradley E ; KILPIVAARA, Outi ; VERSTOVSEK, Srdan ; LEVINE, Ross L ; MANSHOURI, Taghi ; ADLI, Mazhar ; HRICIK, Todd ; FAN LIU ; SAUNDERS, Lindsay M ; MULLALLY, Ann ; ABDEL-WAHAB, Omar

Nature (London), 2012-09, Vol.489 (7414), p.155-159 [Periódico revisado por pares]

London: Nature Publishing Group

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2
Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
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Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

QUINTAS-CARDAMA, Alfonso ; VERSTOVSEK, Srdan

Clinical cancer research, 2013-04, Vol.19 (8), p.1933-1940 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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3
Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19
Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19
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Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

Zhang, Xiuhong ; Zhang, Yan ; Qiao, Weizhen ; Zhang, Ji ; Qi, Zhigang

International immunopharmacology, 2020-09, Vol.86, p.106749-106749, Article 106749 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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4
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
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Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

Maude, Shannon L. ; Tasian, Sarah K. ; Vincent, Tiffaney ; Hall, Junior W. ; Sheen, Cecilia ; Roberts, Kathryn G. ; Seif, Alix E. ; Barrett, David M. ; Chen, I-Ming ; Collins, J. Racquel ; Mullighan, Charles G. ; Hunger, Stephen P. ; Harvey, Richard C. ; Willman, Cheryl L. ; Fridman, Jordan S. ; Loh, Mignon L. ; Grupp, Stephan A. ; Teachey, David T.

Blood, 2012-10, Vol.120 (17), p.3510-3518 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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5
Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial
Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial
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Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial

Reich, Kristian ; Kabashima, Kenji ; Peris, Ketty ; Silverberg, Jonathan I ; Eichenfield, Lawrence F ; Bieber, Thomas ; Kaszuba, Aleksandra ; Kolodsick, Jill ; Yang, Fan E ; Gamalo, Margaret ; Brinker, Dennis R ; DeLozier, Amy M ; Janes, Jonathan M ; Nunes, Fabio P ; Thyssen, Jacob P ; Simpson, Eric L

Archives of dermatology (1960), 2020-12, Vol.156 (12), p.1333-1343 [Periódico revisado por pares]

United States: American Medical Association

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6
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma
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IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

Biffi, Giulia ; Oni, Tobiloba E ; Spielman, Benjamin ; Hao, Yuan ; Elyada, Ela ; Park, Youngkyu ; Preall, Jonathan ; Tuveson, David A

Cancer discovery, 2019-02, Vol.9 (2), p.282-301

United States

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7
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms
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JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms

Parampalli Yajnanarayana, Sowmya ; Stübig, Thomas ; Cornez, Isabelle ; Alchalby, Haefaa ; Schönberg, Kathrin ; Rudolph, Janna ; Triviai, Ioanna ; Wolschke, Christine ; Heine, Annkristin ; Brossart, Peter ; Kröger, Nicolaus ; Wolf, Dominik

British journal of haematology, 2015-06, Vol.169 (6), p.824-833 [Periódico revisado por pares]

England

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8
Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway
Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway
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Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

Tang, Liu-Ya ; Heller, Mary ; Meng, Zhaojing ; Yu, Li-Rong ; Tang, Yi ; Zhou, Ming ; Zhang, Ying E.

The Journal of biological chemistry, 2017-03, Vol.292 (10), p.4302-4312 [Periódico revisado por pares]

United States: Elsevier Inc

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9
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML
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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML

Karjalainen, Riikka ; Pemovska, Tea ; Popa, Mihaela ; Liu, Minxia ; Javarappa, Komal K. ; Majumder, Muntasir M. ; Yadav, Bhagwan ; Tamborero, David ; Tang, Jing ; Bychkov, Dmitrii ; Kontro, Mika ; Parsons, Alun ; Suvela, Minna ; Mayoral Safont, Mireia ; Porkka, Kimmo ; Aittokallio, Tero ; Kallioniemi, Olli ; McCormack, Emmet ; Gjertsen, Bjørn T. ; Wennerberg, Krister ; Knowles, Jonathan ; Heckman, Caroline A.

Blood, 2017-08, Vol.130 (6), p.789-802 [Periódico revisado por pares]

United States: Elsevier Inc

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10
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
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The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

Boyle, D L ; Soma, K ; Hodge, J ; Kavanaugh, A ; Mandel, D ; Mease, P ; Shurmur, R ; Singhal, A K ; Wei, N ; Rosengren, S ; Kaplan, I ; Krishnaswami, S ; Luo, Z ; Bradley, J ; Firestein, G S

Annals of the rheumatic diseases, 2015-06, Vol.74 (6), p.1311-1316 [Periódico revisado por pares]

England: BMJ Publishing Group

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