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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

KOPPIKAR, Priya ; BHAGWAT, Neha ; LEUNG, Laura ; WEINSTEIN, Abby ; MARUBAYASHI, Sachie ; GOEL, Aviva ; GÖNEN, Mithat ; ESTROV, Zeev ; EBERT, Benjamin L ; CHIOSIS, Gabriela ; NIMER, Stephen D ; BERNSTEIN, Bradley E ; KILPIVAARA, Outi ; VERSTOVSEK, Srdan ; LEVINE, Ross L ; MANSHOURI, Taghi ; ADLI, Mazhar ; HRICIK, Todd ; FAN LIU ; SAUNDERS, Lindsay M ; MULLALLY, Ann ; ABDEL-WAHAB, Omar

Nature (London), 2012-09, Vol.489 (7414), p.155-159 [Periódico revisado por pares]

London: Nature Publishing Group

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2
A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro
A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro
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A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

Murakami, Kohei ; Kobayashi, Yasuhiro ; Uehara, Shunsuke ; Suzuki, Takako ; Koide, Masanori ; Yamashita, Teruhito ; Nakamura, Midori ; Takahashi, Naoyuki ; Kato, Hiroyuki ; Udagawa, Nobuyuki ; Nakamura, Yukio Reddy, Sakamuri V.

PloS one, 2017-07, Vol.12 (7), p.e0181126-e0181126 [Periódico revisado por pares]

United States: Public Library of Science

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3
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Glassman, Caleb R ; Tsutsumi, Naotaka ; Saxton, Robert A ; Lupardus, Patrick J ; Jude, Kevin M ; Garcia, K Christopher

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6589), p.163-169 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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4
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway
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Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Ollila, Saara ; Domènech-Moreno, Eva ; Laajanen, Kaisa ; Wong, Iris Pl ; Tripathi, Sushil ; Pentinmikko, Nalle ; Gao, Yajing ; Yan, Yan ; Niemelä, Elina H ; Wang, Timothy C ; Viollet, Benoit ; Leone, Gustavo ; Katajisto, Pekka ; Vaahtomeri, Kari ; Mäkelä, Tomi P

The Journal of clinical investigation, 2018-01, Vol.128 (1), p.402-414 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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5
Identification of essential genes for cancer immunotherapy
Identification of essential genes for cancer immunotherapy
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Identification of essential genes for cancer immunotherapy

Patel, Shashank J ; Sanjana, Neville E ; Kishton, Rigel J ; Eidizadeh, Arash ; Vodnala, Suman K ; Cam, Maggie ; Gartner, Jared J ; Jia, Li ; Steinberg, Seth M ; Yamamoto, Tori N ; Merchant, Anand S ; Mehta, Gautam U ; Chichura, Anna ; Shalem, Ophir ; Tran, Eric ; Eil, Robert ; Sukumar, Madhusudhanan ; Guijarro, Eva Perez ; Day, Chi-Ping ; Robbins, Paul ; Feldman, Steve ; Merlino, Glenn ; Zhang, Feng ; Restifo, Nicholas P

Nature (London), 2017-08, Vol.548 (7669), p.537-542 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
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Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia

Almiron Bonnin, D A ; Havrda, M C ; Lee, M C ; Liu, H ; Zhang, Z ; Nguyen, L N ; Harrington, L X ; Hassanpour, S ; Cheng, C ; Israel, M A

Oncogene, 2018-02, Vol.37 (8), p.1107-1118 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
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Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Barata, João T ; Zenatti, Priscila P ; Ribeiro, Daniel ; Li, Wenqing ; Zuurbier, Linda ; Silva, Milene C ; Paganin, Maddalena ; Tritapoe, Julia ; Hixon, Julie A ; Silveira, André B ; Cardoso, Bruno A ; Sarmento, Leonor M ; Correia, Nádia ; Toribio, Maria L ; Kobarg, Jörg ; Horstmann, Martin ; Pieters, Rob ; Brandalise, Silvia R ; Ferrando, Adolfo A ; Meijerink, Jules P ; Durum, Scott K ; Yunes, J Andrés

Nature genetics, 2011-10, Vol.43 (10), p.932-939 [Periódico revisado por pares]

New York, NY: Nature Publishing Group

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8
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment
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JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

Zhang, Yun ; Liang, Ruifang ; Chen, Chih-Wei ; Mallano, Tatjana ; Dees, Clara ; Distler, Alfiya ; Reich, Adam ; Bergmann, Christina ; Ramming, Andreas ; Gelse, Kolja ; Mielenz, Dirk ; Distler, Oliver ; Schett, Georg ; Distler, Jörg H W

Annals of the rheumatic diseases, 2017-08, Vol.76 (8), p.1467-1475 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

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9
Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
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Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

BERTHIER, Celine C ; HONGYU ZHANG ; ARGETSINGER, Lawrence S ; RASTALDI, Maria P ; BROSIUS, Frank C ; KRETZLER, Matthias ; SCHIN, Marylee ; HENGER, Anna ; NELSON, Robert G ; YEE, Berne ; BOUCHEROT, Anissa ; NEUSSER, Matthias A ; COHEN, Clemens D ; CARTER-SU, Christin

Diabetes (New York, N.Y.), 2009-02, Vol.58 (2), p.469-477 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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10
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
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The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

Boyle, D L ; Soma, K ; Hodge, J ; Kavanaugh, A ; Mandel, D ; Mease, P ; Shurmur, R ; Singhal, A K ; Wei, N ; Rosengren, S ; Kaplan, I ; Krishnaswami, S ; Luo, Z ; Bradley, J ; Firestein, G S

Annals of the rheumatic diseases, 2015-06, Vol.74 (6), p.1311-1316 [Periódico revisado por pares]

England: BMJ Publishing Group

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