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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

KOPPIKAR, Priya ; BHAGWAT, Neha ; LEUNG, Laura ; WEINSTEIN, Abby ; MARUBAYASHI, Sachie ; GOEL, Aviva ; GÖNEN, Mithat ; ESTROV, Zeev ; EBERT, Benjamin L ; CHIOSIS, Gabriela ; NIMER, Stephen D ; BERNSTEIN, Bradley E ; KILPIVAARA, Outi ; VERSTOVSEK, Srdan ; LEVINE, Ross L ; MANSHOURI, Taghi ; ADLI, Mazhar ; HRICIK, Todd ; FAN LIU ; SAUNDERS, Lindsay M ; MULLALLY, Ann ; ABDEL-WAHAB, Omar

Nature (London), 2012-09, Vol.489 (7414), p.155-159 [Periódico revisado por pares]

London: Nature Publishing Group

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2
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
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Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

Porpaczy, Edit ; Tripolt, Sabrina ; Hoelbl-Kovacic, Andrea ; Gisslinger, Bettina ; Bago-Horvath, Zsuzsanna ; Casanova-Hevia, Emilio ; Clappier, Emmanuelle ; Decker, Thomas ; Fajmann, Sabine ; Fux, Daniela A. ; Greiner, Georg ; Gueltekin, Sinan ; Heller, Gerwin ; Herkner, Harald ; Hoermann, Gregor ; Kiladjian, Jean-Jacques ; Kolbe, Thomas ; Kornauth, Christoph ; Krauth, Maria-Theresa ; Kralovics, Robert ; Muellauer, Leonhard ; Mueller, Mathias ; Prchal-Murphy, Michaela ; Putz, Eva Maria ; Raffoux, Emmanuel ; Schiefer, Ana-Iris ; Schmetterer, Klaus ; Schneckenleithner, Christine ; Simonitsch-Klupp, Ingrid ; Skrabs, Cathrin ; Sperr, Wolfgang R. ; Staber, Philipp Bernhard ; Strobl, Birgit ; Valent, Peter ; Jaeger, Ulrich ; Gisslinger, Heinz ; Sexl, Veronika

Blood, 2018-08, Vol.132 (7), p.694-706 [Periódico revisado por pares]

United States: Elsevier Inc

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3
Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
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Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Lupardus, Patrick J. ; Ultsch, Mark ; Wallweber, Heidi ; Kohli, Pawan Bir ; Johnson, Adam R. ; Eigenbrot, Charles

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (22), p.8025-8030 [Periódico revisado por pares]

United States: National Academy of Sciences

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4
Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
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Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

QUINTAS-CARDAMA, Alfonso ; VERSTOVSEK, Srdan

Clinical cancer research, 2013-04, Vol.19 (8), p.1933-1940 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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5
JAK mutations in high-risk childhood acute lymphoblastic leukemia
JAK mutations in high-risk childhood acute lymphoblastic leukemia
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JAK mutations in high-risk childhood acute lymphoblastic leukemia

Mullighan, Charles G ; Zhang, Jinghui ; Harvey, Richard C ; Collins-Underwood, J. Racquel ; Schulman, Brenda A ; Phillips, Letha A ; Tasian, Sarah K ; Loh, Mignon L ; Su, Xiaoping ; Liu, Wei ; Devidas, Meenakshi ; Atlas, Susan R ; Chen, I. Ming ; Clifford, Robert J ; Gerhard, Daniela S ; Carroll, William L ; Reaman, Gregory H ; Smith, Malcolm ; Downing, James R ; Hunger, Stephen P ; Willman, Cheryl L

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (23), p.9414-9418 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial
Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial
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Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial

Reich, Kristian ; Kabashima, Kenji ; Peris, Ketty ; Silverberg, Jonathan I ; Eichenfield, Lawrence F ; Bieber, Thomas ; Kaszuba, Aleksandra ; Kolodsick, Jill ; Yang, Fan E ; Gamalo, Margaret ; Brinker, Dennis R ; DeLozier, Amy M ; Janes, Jonathan M ; Nunes, Fabio P ; Thyssen, Jacob P ; Simpson, Eric L

Archives of dermatology (1960), 2020-12, Vol.156 (12), p.1333-1343 [Periódico revisado por pares]

United States: American Medical Association

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7
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling
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African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling

Li, Dan ; Zhang, Jing ; Yang, Wenping ; Li, Pan ; Ru, Yi ; Kang, Weifang ; Li, LuLu ; Ran, Yong ; Zheng, Haixue

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101190-101190, Article 101190 [Periódico revisado por pares]

United States: Elsevier Inc

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8
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
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Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

Maude, Shannon L. ; Tasian, Sarah K. ; Vincent, Tiffaney ; Hall, Junior W. ; Sheen, Cecilia ; Roberts, Kathryn G. ; Seif, Alix E. ; Barrett, David M. ; Chen, I-Ming ; Collins, J. Racquel ; Mullighan, Charles G. ; Hunger, Stephen P. ; Harvey, Richard C. ; Willman, Cheryl L. ; Fridman, Jordan S. ; Loh, Mignon L. ; Grupp, Stephan A. ; Teachey, David T.

Blood, 2012-10, Vol.120 (17), p.3510-3518 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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9
Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients
Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients
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Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients

Kim, Hanna ; Brooks, Kristina M. ; Tang, Cheng Cai ; Wakim, Paul ; Blake, Mary ; Brooks, Stephen R. ; Montealegre Sanchez, Gina A. ; de Jesus, Adriana A. ; Huang, Yan ; Tsai, Wanxia Li ; Gadina, Massimo ; Prakash, Apurva ; Janes, Jonathan Marcus ; Zhang, Xin ; Macias, William L. ; Kumar, Parag ; Goldbach‐Mansky, Raphaela

Clinical pharmacology and therapeutics, 2018-08, Vol.104 (2), p.364-373 [Periódico revisado por pares]

United States

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10
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Glassman, Caleb R ; Tsutsumi, Naotaka ; Saxton, Robert A ; Lupardus, Patrick J ; Jude, Kevin M ; Garcia, K Christopher

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6589), p.163-169 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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