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Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neuronsWang, Lijun ; Grisotti, Gabriella ; Roos, Raymond PJournal of neurochemistry, 2010-04, Vol.113 (1), p.166-174 [Periódico revisado por pares]Oxford, UK: Oxford, UK : Blackwell Publishing LtdTexto completo disponível |
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Material Type: Artigo
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse modelGuttenplan, Kevin A. ; Weigel, Maya K. ; Adler, Drew I. ; Couthouis, Julien ; Liddelow, Shane A. ; Gitler, Aaron D. ; Barres, Ben A.Nature communications, 2020-07, Vol.11 (1), p.1-9, Article 3753 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genesHumphrey, Jack ; Venkatesh, Sanan ; Hasan, Rahat ; Herb, Jake T ; de Paiva Lopes, Katia ; Küçükali, Fahri ; Byrska-Bishop, Marta ; Evani, Uday S ; Narzisi, Giuseppe ; Fagegaltier, Delphine ; Sleegers, Kristel ; Phatnani, Hemali ; Knowles, David A ; Fratta, Pietro ; Raj, TowfiqueNature neuroscience, 2023-01, Vol.26 (1), p.150-162 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man studyMiller, Timothy M, Dr ; Pestronk, Alan, Prof ; David, William, MD ; Rothstein, Jeffrey, Prof ; Simpson, Ericka, MD ; Appel, Stanley H, Prof ; Andres, Patricia L, MS ; Mahoney, Katy, BA ; Allred, Peggy, DPT ; Alexander, Katie, BA ; Ostrow, Lyle W, MD ; Schoenfeld, David, Prof ; Macklin, Eric A, PhD ; Norris, Daniel A, PhD ; Manousakis, Georgios, MD ; Crisp, Matthew, BS ; Smith, Richard, MD ; Bennett, C Frank, PhD ; Bishop, Kathie M, PhD ; Cudkowicz, Merit E, ProfLancet neurology, 2013-05, Vol.12 (5), p.435-442 [Periódico revisado por pares]England: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Metal migration and subunit swapping in ALS-linked SOD1: Zn2+ transfer between mutant and wild-type occurs faster than the rate of heterodimerizationDashnaw, Chad M. ; Zhang, Ao Yun ; Gonzalez, Mayte ; Koone, Jordan C. ; Shaw, Bryan F.The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102610, Article 102610 [Periódico revisado por pares]Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seedingRasouli, Sanaz ; Abdolvahabi, Alireza ; Croom, Corbin M. ; Plewman, Devon L. ; Shi, Yunhua ; Ayers, Jacob I. ; Shaw, Bryan F.The Journal of biological chemistry, 2017-11, Vol.292 (47), p.19366-19380 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Role of Extracellular Vesicles in Amyotrophic Lateral SclerosisFerrara, Deborah ; Pasetto, Laura ; Bonetto, Valentina ; Basso, ManuelaFrontiers in neuroscience, 2018-08, Vol.12, p.574-574 [Periódico revisado por pares]Switzerland: Frontiers Research FoundationTexto completo disponível |
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Material Type: Artigo
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The contribution of the peripheral immune system to neurodegenerationBerriat, Félix ; Lobsiger, Christian S ; Boillée, SéverineNature neuroscience, 2023-06, Vol.26 (6), p.942-954 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Palmitoylation of Superoxide Dismutase 1 (SOD1) Is Increased for Familial Amyotrophic Lateral Sclerosis-linked SOD1 MutantsAntinone, Sarah E. ; Ghadge, Ghanashyam D. ; Lam, Tukiet T. ; Wang, Lijun ; Roos, Raymond P. ; Green, William N.The Journal of biological chemistry, 2013-07, Vol.288 (30), p.21606-21617 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Material Type: Artigo
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A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain PatientsLind, Anne-Li ; Wu, Di ; Freyhult, Eva ; Bodolea, Constantin ; Ekegren, Titti ; Larsson, Anders ; Gustafsson, Mats G ; Katila, Lenka ; Bergquist, Jonas ; Gordh, Torsten ; Landegren, Ulf ; Kamali-Moghaddam, Masood Pandey, UdaiPloS one, 2016-02, Vol.11 (2), p.e0149821-e0149821 [Periódico revisado por pares]United States: Public Library of ScienceTexto completo disponível |