Abstract 6596: BRMS1 downregulation alters the tumor microenvironment and induces immunotherapy resistance in lung adenocarcinoma

Lankadasari, Manendra B. ; Liu, Yuan ; Mastrogiacomo, Brooke ; Zhu, Yingjie ; Dunne, Elizabeth G. ; Fick, Cameron N. ; Harsha, Choudhary ; Reis-Filho, Jorge S. ; Jones, David R.

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Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study

Tsai, Chiaojung Jillian ; Yang, Jonathan T ; Shaverdian, Narek ; Patel, Juber ; Shepherd, Annemarie F ; Eng, Juliana ; Guttmann, David ; Yeh, Randy ; Gelblum, Daphna Y ; Namakydoust, Azadeh ; Preeshagul, Isabel ; Modi, Shanu ; Seidman, Andrew ; Traina, Tiffany ; Drullinsky, Pamela ; Flynn, Jessica ; Zhang, Zhigang ; Rimner, Andreas ; Gillespie, Erin F ; Gomez, Daniel R ; Lee, Nancy Y ; Berger, Michael ; Robson, Mark E ; Reis-Filho, Jorge S ; Riaz, Nadeem ; Rudin, Charles M ; Powell, Simon N ; Berger, Michael ; Bromberg, Jacqueline ; Chen, Linda ; Dang, Chau ; Das, Jeeban P ; Drullinsky, Pamela ; Eng, Julianna ; Flynn, Jessica ; Gelblum, Daphna Y ; Gillespie, Erin F ; Girshman, Jeffrey ; Gomez, Daniel R ; Gucalp, Ayca ; Guttmann, David ; Hajj, Carla ; Higginson, Daniel ; Iqbal, Afsheen ; Khan, Atif J ; LaPlant, Quincey ; Lee, Nancy Y ; Mann, Justin M ; Modi, Shanu ; Namakydoust, Azadeh ; Ng, Kenneth ; Patel, Juber ; Powell, Simon N ; Preeshagul, Isabel ; Reis-Filho, Jorge S ; Reyngold, Marsha ; Riaz, Nadeem ; Rimner, Andreas ; Robson, Mark E ; Rudin, Charles M ; Sanford, Rachel ; Seidman, Andrew D ; Shah, Ronak ; Shaverdian, Narek ; Shepherd, Annemarie F ; Shin, Jacob Y ; Sugarman, Steven ; Traina, Tiffany A ; Tsai, Chiaojung Jillian ; Wu, Abraham J ; Xu, Amy J ; Yang, Jonathan T ; Yeh, Randy ; Zhang, Zhigang ; Zhi, Wanqing

England: Elsevier Ltd

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Most large structural variants in cancer genomes can be detected without long reads

Choo, Zi-Ning ; Behr, Julie M ; Deshpande, Aditya ; Hadi, Kevin ; Yao, Xiaotong ; Tian, Huasong ; Takai, Kaori ; Zakusilo, George ; Rosiene, Joel ; Da Cruz Paula, Arnaud ; Weigelt, Britta ; Setton, Jeremy ; Riaz, Nadeem ; Powell, Simon N ; Busam, Klaus ; Shoushtari, Alexander N ; Ariyan, Charlotte ; Reis-Filho, Jorge ; de Lange, Titia ; Imieliński, Marcin

United States: Nature Publishing Group

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Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers

Setton, Jeremy ; Hadi, Kevin ; Choo, Zi-Ning ; Kuchin, Katherine S. ; Tian, Huasong ; Da Cruz Paula, Arnaud ; Rosiene, Joel ; Selenica, Pier ; Behr, Julie ; Yao, Xiaotong ; Deshpande, Aditya ; Sigouros, Michael ; Manohar, Jyothi ; Nauseef, Jones T. ; Mosquera, Juan-Miguel ; Elemento, Olivier ; Weigelt, Britta ; Riaz, Nadeem ; Reis-Filho, Jorge S. ; Powell, Simon N. ; Imieliński, Marcin

London: Nature Publishing Group

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Abstract 6421: Molecular profiles and single cell analysis identify immunogenic pancreatic ductal adenocarcinoma (iPDAC)

Park, Wungki ; O'Connor, Catherine ; Umeda, Shigeaki ; Sharma, Roshan ; Zhu, Yingjie ; Karnoub, Elias-Ramzey ; Varghese, Anna ; Soares, Kevin C. ; Jimemez, Alejandro ; Yavas, Asli ; Yu, Kenneth H. ; Vinod, Balachandran P. ; Chou, Joanne F. ; Khalil, Danny N. ; David, Kelsen ; Ozkan, Hulya Sahin ; Basturk, Olca ; Capanu, Marinela ; Nawy, Tal ; Berger, Michael F. ; Abou-Alfa, Ghassan K. ; Reis-Filho, Jorge S. ; Chaligne, Ronan ; Riaz, Nadeem ; Pe'er, Dana ; Iacobuzio-Donahue, Christine ; O'Reilly, Eileen M.

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Abstract 6063: Genomic characterization of non-small cell lung cancer (NSCLC) brain metastasis (BM) patients identifies novel alterations associated with tropisms and disease progression

Walch, Henry ; Skakodub, Anna ; Tringale, Kathryn R. ; Vasudevan, Harish N. ; Eichholz, Jordan ; Kelly, Daniel W. ; Lebow, Emily ; Moss, Nelson S. ; Yu, Kenny Kwok Hei ; Li, Bob T. ; Mueller, Boris ; Khan, Atif ; Yu, Yao ; Powell, Simon ; Reis-Filho, Jorge S. ; Imber, Brandon S. ; Razavi, Pedram ; Gomez, Daniel R. ; Schultz, Nikolaus ; Pike, Luke R.

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High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer

Ashley, Charles W ; Selenica, Pier ; Patel, Juber ; Wu, Michelle ; Nincevic, Josip ; Lakhman, Yulia ; Zhou, Qin ; Shah, Ronak H ; Berger, Michael F ; Da Cruz Paula, Arnaud ; Brown, David N ; Marra, Antonio ; Iasonos, Alexia ; Momeni-Boroujeni, Amir ; Alektiar, Kaled M ; Long Roche, Kara ; Zivanovic, Oliver ; Mueller, Jennifer J ; Zamarin, Dmitriy ; Broach, Vance A ; Sonoda, Yukio ; Leitao, Mario M ; Friedman, Claire F ; Jewell, Elizabeth ; Reis-Filho, Jorge S ; Ellenson, Lora H ; Aghajanian, Carol ; Abu-Rustum, Nadeem R ; Cadoo, Karen ; Weigelt, Britta

United States

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Abstract 5688: RNA-mediated DNA repair: A novel repair pathway in homologous recombination-deficient cancers

Jalan, Manisha ; Patel, Juber ; Olsen, Kyrie S ; Ahmed-Seghir, Sana ; Higginson, Daniel S ; Reis-Filho, Jorge S ; Riaz, Nadeem ; Powell, Simon N

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Allelic dosage of RB1 drives CDK4/6 inhibitor treatment resistance in metastatic breast cancer

Safonov, Anton Mikhailovich ; Bandlamudi, Chaitanya ; Selenica, Pier ; Marra, Antonio ; Ferraro, Emanuela ; Mandelker, Diana ; Solit, David B. ; Berger, Michael F. ; Norton, Larry ; Powell, Simon N. ; Shen, Ronglai ; Robson, Mark E. ; Chandarlapaty, Sarat ; Reis-Filho, Jorge S. ; Razavi, Pedram

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Impact of clonal hematopoiesis on tumor control following radiation therapy

Tao, Jacqueline ; Setton, Jeremy ; Sanchez Vela, Pablo ; Safonov, Anton Mikhailovich ; Comen, Elizabeth Anne ; Braunstein, Lior Zvi ; Reis-Filho, Jorge S. ; Riaz, Nadeem ; Powell, Simon N. ; Levine, Ross L. ; Norton, Larry ; Khan, Atif J. ; Razavi, Pedram

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