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1
In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics
In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics
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In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics

DAWSON, Lee A ; LANGMEAD, Christopher J ; HILL, Mark D ; JONES, Declan N. C ; DAVIES, Ceri H ; HAGAN, Jim J ; SMITH, Paul W ; DADA, Adeshola ; WATSON, Jeannette M ; ZINING WU ; DE LA FLOR, Raúl ; JONES, Gareth A ; CLUDERAY, Jane E ; SOUTHAM, Eric ; MURKITT, Graham S

European journal of pharmacology, 2010-02, Vol.627 (1-3), p.106-114 [Periódico revisado por pares]

Amsterdam: Elsevier

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2
BGC20‐1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache
BGC20‐1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache
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BGC20‐1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache

Maubach, KA ; Davis, RJ ; Clark, DE ; Fenton, G ; Lockey, PM ; Clark, KL ; Oxford, AW ; Hagan, RM ; Routledge, C ; Coleman, RA

British journal of pharmacology, 2009-01, Vol.156 (2), p.316-327 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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3
Contraceptive and noncontraceptive benefits of the LNG-IUS in a vertically integrated HMO
Contraceptive and noncontraceptive benefits of the LNG-IUS in a vertically integrated HMO
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Contraceptive and noncontraceptive benefits of the LNG-IUS in a vertically integrated HMO

Hendlish, Sarah K ; Horowicz-Mehler, Nathalie C ; Brixner, Diana I ; Stern, Lee S ; Doyle, John J ; Chang, Joanne ; Hagan, Michael

Contraception (Stoneham), 2008-07, Vol.78 (1), p.36-41 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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4
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1
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Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1

Langmead, C J ; Austin, N E ; Branch, C L ; Brown, J T ; Buchanan, K A ; Davies, C H ; Forbes, I T ; Fry, V A H ; Hagan, J J ; Herdon, H J ; Jones, G A ; Jeggo, R ; Kew, J N C ; Mazzali, A ; Melarange, R ; Patel, N ; Pardoe, J ; Randall, A D ; Roberts, C ; Roopun, A ; Starr, K R ; Teriakidis, A ; Wood, M D ; Whittington, M ; Wu, Z ; Watson, J

British journal of pharmacology, 2008-07, Vol.154 (5), p.1104-1115 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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5
Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Meng, Wei ; Ellsworth, Bruce A ; Nirschl, Alexandra A ; McCann, Peggy J ; Patel, Manorama ; Girotra, Ravindar N ; Wu, Gang ; Sher, Philip M ; Morrison, Eamonn P ; Biller, Scott A ; Zahler, Robert ; Deshpande, Prashant P ; Pullockaran, Annie ; Hagan, Deborah L ; Morgan, Nathan ; Taylor, Joseph R ; Obermeier, Mary T ; Humphreys, William G ; Khanna, Ashish ; Discenza, Lorell ; Robertson, James G ; Wang, Aiying ; Han, Songping ; Wetterau, John R ; Janovitz, Evan B ; Flint, Oliver P ; Whaley, Jean M ; Washburn, William N

Journal of medicinal chemistry, 2008-03, Vol.51 (5), p.1145-1149 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D3 Receptor Antagonists
1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D3 Receptor Antagonists
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1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D3 Receptor Antagonists

Micheli, Fabrizio ; Bonanomi, Giorgio ; Blaney, Frank E ; Braggio, Simone ; Capelli, Anna Maria ; Checchia, Anna ; Curcuruto, Ornella ; Damiani, Federica ; Di Fabio, Romano ; Donati, Daniele ; Gentile, Gabriella ; Gribble, Andy ; Hamprecht, Dieter ; Tedesco, Giovanna ; Terreni, Silvia ; Tarsi, Luca ; Lightfoot, Andrew ; Stemp, Geoff ; MacDonald, Gregor ; Smith, Alex ; Pecoraro, Michela ; Petrone, Marcella ; Perini, Ornella ; Piner, Jacqui ; Rossi, Tino ; Worby, Angela ; Pilla, Maria ; Valerio, Enzo ; Griffante, Cristiana ; Mugnaini, Manolo ; Wood, Martyn ; Scott, Claire ; Andreoli, Michela ; Lacroix, Laurent ; Schwarz, Adam ; Gozzi, Alessandro ; Bifone, Angelo ; Ashby, Charles R ; Hagan, Jim J ; Heidbreder, Christian

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5076-5089 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study
Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study
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Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study

Sosabowski, Jane K. ; Lee, Myrto ; Dekker, Bronwen A. ; Simmons, Ben P. ; Singh, Surjeet ; Beresford, Hayden ; Hagan, Susan A. ; McKenzie, Andrew J. ; Mather, Stephen J. ; Watson, Susan A.

European journal of pharmaceutical sciences, 2007-06, Vol.31 (2), p.102-111 [Periódico revisado por pares]

Shannon: Elsevier B.V

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8
Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs : in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B
Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs : in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B
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Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs : in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

HUGHES, Zoë A ; STARR, Kathryn R ; SCOTT, Claire M ; NEWSON, Michael J ; SHARP, Trevor ; WATSON, Jeannette M ; HAGAN, Jim J ; DAWSON, Lee A

Psychopharmacologia, 2007-05, Vol.192 (1), p.121-133 [Periódico revisado por pares]

Berlin: Springer

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9
Studies towards the identification of a new generation of atypical antipsychotic agents
Studies towards the identification of a new generation of atypical antipsychotic agents
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Studies towards the identification of a new generation of atypical antipsychotic agents

Garzya, Vincenzo ; Forbes, Ian T. ; Gribble, Andrew D. ; Hadley, Mike S. ; Lightfoot, Andrew P. ; Payne, Andrew H. ; Smith, Alexander B. ; Douglas, Sara E. ; Cooper, David G. ; Stansfield, Ian G. ; Meeson, Malcom ; Dodds, Emma E. ; Jones, Declan N.C. ; Wood, Martyn ; Reavill, Charlie ; Scorer, Carol A. ; Worby, Angela ; Riley, Graham ; Eddershaw, Peter ; Ioannou, Chris ; Donati, Daniele ; Hagan, Jim J. ; Ratti, Emiliangelo A.

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.400-405 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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10
SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test
SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test
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SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

STARR, Kathryn R ; PRICE, Gary W ; WATSON, Jeannette M ; ATKINSON, Peter J ; ARBAN, Roberto ; MELOTTO, Sergio ; DAWSON, Lee A ; HAGAN, Jim J ; UPTON, Neil ; DUXON, Mark S

Neuropsychopharmacology (New York, N.Y.), 2007, Vol.32 (10), p.2163-2172 [Periódico revisado por pares]

New York, NY: Nature Publishing

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