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Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms
Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms
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Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms

Brown, Jeremy ; Bush, Inle ; Bozon, Justine ; Su, Tin Tin Bosco, Giovanni

PLoS genetics, 2020-10, Vol.16 (10), p.e1009056-e1009056 [Periódico revisado por pares]

United States: Public Library of Science

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2
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Merkle, Florian T ; Ghosh, Sulagna ; Kamitaki, Nolan ; Mitchell, Jana ; Avior, Yishai ; Mello, Curtis ; Kashin, Seva ; Mekhoubad, Shila ; Ilic, Dusko ; Charlton, Maura ; Saphier, Genevieve ; Handsaker, Robert E ; Genovese, Giulio ; Bar, Shiran ; Benvenisty, Nissim ; McCarroll, Steven A ; Eggan, Kevin

Nature (London), 2017-05, Vol.545 (7653), p.229-233 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Juric, Dejan ; Castel, Pau ; Griffith, Malachi ; Griffith, Obi L ; Won, Helen H ; Ellis, Haley ; Ebbesen, Saya H ; Ainscough, Benjamin J ; Ramu, Avinash ; Iyer, Gopa ; Shah, Ronak H ; Huynh, Tiffany ; Mino-Kenudson, Mari ; Sgroi, Dennis ; Isakoff, Steven ; Thabet, Ashraf ; Elamine, Leila ; Solit, David B ; Lowe, Scott W ; Quadt, Cornelia ; Peters, Malte ; Derti, Adnan ; Schegel, Robert ; Huang, Alan ; Mardis, Elaine R ; Berger, Michael F ; Baselga, José ; Scaltriti, Maurizio

Nature (London), 2015-02, Vol.518 (7538), p.240-244 [Periódico revisado por pares]

England

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4
Monogenic and polygenic inheritance become instruments for clonal selection
Monogenic and polygenic inheritance become instruments for clonal selection
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Monogenic and polygenic inheritance become instruments for clonal selection

Loh, Po-Ru ; Genovese, Giulio ; McCarroll, Steven A

Nature (London), 2020-08, Vol.584 (7819), p.136-141 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Targeting loss of heterozygosity for cancer-specific immunotherapy
Targeting loss of heterozygosity for cancer-specific immunotherapy
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Targeting loss of heterozygosity for cancer-specific immunotherapy

Hwang, Michael S ; Mog, Brian J ; Douglass, Jacqueline ; Pearlman, Alexander H ; Hsiue, Emily Han-Chung ; Paul, Suman ; DiNapoli, Sarah R ; Konig, Maximilian F ; Pardoll, Drew M ; Gabelli, Sandra B ; Bettegowda, Chetan ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Zhou, Shibin ; Kinzler, Kenneth W

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (12), p.1 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi‐directional loss of heterozygosity in bone marrow progenitors
Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi‐directional loss of heterozygosity in bone marrow progenitors
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Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi‐directional loss of heterozygosity in bone marrow progenitors

Shetzer, Yoav ; Napchan, Yael ; Kaufman, Tom ; Molchadsky, Alina ; Tal, Perry ; Goldfinger, Naomi ; Rotter, Varda

International journal of cancer, 2017-03, Vol.140 (6), p.1364-1369 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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7
Fitness benefits of loss of heterozygosity in Saccharomyces hybrids
Fitness benefits of loss of heterozygosity in Saccharomyces hybrids
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Fitness benefits of loss of heterozygosity in Saccharomyces hybrids

Lancaster, Samuel M ; Payen, Celia ; Smukowski Heil, Caiti ; Dunham, Maitreya J

Genome research, 2019-10, Vol.29 (10), p.1685-1692 [Periódico revisado por pares]

United States: Cold Spring Harbor Laboratory Press

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8
A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
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A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

Pyke, Rachel Marty ; Mellacheruvu, Dattatreya ; Dea, Steven ; Abbott, Charles W ; McDaniel, Lee ; Bhave, Devayani P ; Zhang, Simo V ; Levy, Eric ; Bartha, Gabor ; West, John ; Snyder, Michael P ; Chen, Richard O ; Boyle, Sean Michael

Nature communications, 2022-04, Vol.13 (1), p.1925-1925, Article 1925 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection
Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection
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Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection

James, Timothy Y ; Michelotti, Lucas A ; Glasco, Alexander D ; Clemons, Rebecca A ; Powers, Robert A ; James, Ellen S ; Simmons, D Rabern ; Bai, Fengyan ; Ge, Shuhua

Genetics (Austin), 2019-10, Vol.213 (2), p.665-683 [Periódico revisado por pares]

United States: Genetics Society of America

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10
Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883)
Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883)
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Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883)

Hauke, Jan ; Harter, Philipp ; Ernst, Corinna ; Burges, Alexander ; Schmidt, Sandra ; Reuss, Alexander ; Borde, Julika ; De Gregorio, Nikolaus ; Dietrich, Dimo ; El-Balat, Ahmed ; Kayali, Mohamad ; Gevensleben, Heidrun ; Hilpert, Felix ; Altmüller, Janine ; Heimbach, André ; Meier, Werner ; Schoemig-Markiefka, Birgid ; Thiele, Holger ; Kimmig, Rainer ; Nürnberg, Peter ; Kast, Karin ; Richters, Lisa ; Sehouli, Jalid ; Schmutzler, Rita K ; Hahnen, Eric

Journal of medical genetics, 2022-03, Vol.59 (3), p.248-252 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd

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