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Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3Qiu, Min ; Glass, Zachary ; Chen, Jinjin ; Haas, Mary ; Jin, Xin ; Zhao, Xuewei ; Rui, Xuehui ; Ye, Zhongfeng ; Li, Yamin ; Zhang, Feng ; Xu, QiaobingProceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Recruitment of CRISPR-Cas systems by Tn7-like transposonsPeters, Joseph E. ; Makarova, Kira S. ; Shmakov, Sergey ; Koonin, Eugene V.Proceedings of the National Academy of Sciences - PNAS, 2017-08, Vol.114 (35), p.E7358-E7366 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editingSago, Cory D. ; Lokugamage, Melissa P. ; Paunovska, Kalina ; Vanover, Daryll A. ; Monaco, Christopher M. ; Shah, Nirav N. ; Castro, Marielena Gamboa ; Anderson, Shannon E. ; Rudoltz, Tobi G. ; Lando, Gwyneth N. ; Tiwari, Pooja Mummilal ; Kirschman, Jonathan L. ; Willett, Nick ; Jang, Young C. ; Santangelo, Philip J. ; Bryksin, Anton V. ; Dahlman, James E.Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (42), p.E9944-E9952 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Imaging-based pooled CRISPR screening reveals regulators of lncRNA localizationWang, Chong ; Lu, Tian ; Emanuel, George ; Babcock, Hazen P ; Zhuang, XiaoweiProceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.10842-10851 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Programmable RNA recognition using a CRISPR-associated ArgonauteLapinaite, Audrone ; Doudna, Jennifer A. ; Cate, Jamie H. D.Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (13), p.3368-3373 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)Singh, Digvijay ; Mallon, John ; Poddar, Anustup ; Wang, Yanbo ; Tippana, Ramreddy ; Yang, Olivia ; Bailey, Scott ; Ha, TaekjipProceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (21), p.5444-5449 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Metagenomic discovery of CRISPR-associated transposonsRybarski, James R ; Hu, Kuang ; Hill, Alexis M ; Wilke, Claus O ; Finkelstein, Ilya JProceedings of the National Academy of Sciences - PNAS, 2021-12, Vol.118 (49) [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Germline Cas9 expression yields highly efficient genome engineering in a major worldwide disease vector, Aedes aegyptiLi, Ming ; Bui, Michelle ; Yang, Ting ; Bowman, Christian S. ; White, Bradley J. ; Akbari, Omar S.Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (49), p.E10540-E10549 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA designZhang, Dong ; Hurst, Travis ; Duan, Dongsheng ; Chen, Shi-JieProceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (18), p.8693-8698 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunctionCondon, Kendall J ; Orozco, Jose M ; Adelmann, Charles H ; Spinelli, Jessica B ; van der Helm, Pim W ; Roberts, Justin M ; Kunchok, Tenzin ; Sabatini, David MProceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (4) [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |