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Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors
Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors
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Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

O'Brien, Patrick M ; Ortwine, Daniel F ; Pavlovsky, Alexander G ; Picard, Joseph A ; Sliskovic, Drago R ; Roth, Bruce D ; Dyer, Richard D ; Johnson, Linda L ; Man, Chiu Fai ; Hallak, Hussein

Journal of medicinal chemistry, 2000-01, Vol.43 (2), p.156-166 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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2
Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors
Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors
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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Hamby, James M ; Connolly, Cleo J. C ; Schroeder, Mel C ; Winters, R. Thomas ; Showalter, H. D. Hollis ; Panek, Robert L ; Major, Terry C ; Olsewski, Bronislawa ; Ryan, Michael J ; Dahring, Tawny ; Lu, Gina H ; Keiser, Joan ; Amar, Aneesa ; Shen, Cindy ; Kraker, Alan J ; Slintak, Veronika ; Nelson, James M ; Fry, David W ; Bradford, Laura ; Hallak, Hussein ; Doherty, Annette M

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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3
Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H ; Wu, Zhipei ; Klutchko, Sylvester R ; Showalter, H. D. Hollis ; Hamby, James M ; Lu, Gina H ; Major, Terry C ; Dahring, Tawny K ; Batley, Brian ; Panek, Robert L ; Keiser, Joan ; Hartl, Brian G ; Kraker, Alan J ; Klohs, Wayne D ; Roberts, Bill J ; Patmore, Sandra ; Elliott, William L ; Steinkampf, Randy ; Bradford, Laura A ; Hallak, Hussein ; Doherty, Annette M

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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4
Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists
Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists
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Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists

Doherty, Annette M ; Patt, William C ; Edmunds, Jeremy J ; Berryman, Kent A ; Reisdorph, Billy R ; Plummer, Mark S ; Shahripour, Aurash ; Lee, Chet ; Cheng, Xue-Min

Journal of medicinal chemistry, 1995-04, Vol.38 (8), p.1259-1263 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Klutchko, Sylvester R ; Hamby, James M ; Boschelli, Diane H ; Wu, Zhipei ; Kraker, Alan J ; Amar, Aneesa M ; Hartl, Brian G ; Shen, Cynthia ; Klohs, Wayne D ; Steinkampf, Randall W ; Driscoll, Denise L ; Nelson, James M ; Elliott, William L ; Roberts, Billy J ; Stoner, Chad L ; Vincent, Patrick W ; Dykes, Donald J ; Panek, Robert L ; Lu, Gina H ; Major, Terry C ; Dahring, Tawny K ; Hallak, Hussein ; Bradford, Laura A ; Showalter, H. D. Hollis ; Doherty, Annette M

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3276-3292 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists
Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists
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Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists

Patt, William C ; Edmunds, Jeremy J ; Repine, Joseph T ; Berryman, Kent A ; Reisdorph, Billy R ; Lee, Chet ; Plummer, Mark S ; Shahripour, Aurash ; Haleen, Stephen J ; Keiser, Joan A ; Flynn, Mike A ; Welch, Kathleen M ; Reynolds, Elwood E ; Rubin, Ron ; Tobias, Brian ; Hallak, Hussein ; Doherty, Annette M

Journal of medicinal chemistry, 1997-03, Vol.40 (7), p.1063-1074 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H. ; Wu, Zhipei ; Klutchko, Sylvester R. ; Showalter, H. D. Hollis ; Hamby, James M. ; Lu, Gina H. ; Major, Terry C. ; Dahring, Tawny K. ; Batley, Brian ; Panek, Robert L. ; Keiser, Joan ; Hartl, Brian G. ; Kraker, Alan J. ; Klohs, Wayne D. ; Roberts, Bill J. ; Patmore, Sandra ; Elliott, William L. ; Steinkampf, Randy ; Bradford, Laura A. ; Hallak, Hussein ; Doherty, Annette M.

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377 [Periódico revisado por pares]

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