Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG

Loo, Sun ; Roberts, Andrew W. ; Anstee, Natasha S. ; Kennedy, Glen ; He, Simon ; Schwarer, Anthony P. ; Enjeti, Anoop K. ; D’Rozario, James ; Marlton, Paula ; Bilmon, Ian ; Taper, John ; Cull, Gavin ; Tiley, Campbell ; Verner, Emma ; Hahn, Uwe ; Hiwase, Devendra ; Iland, Harry J. ; Murphy, Nick ; Ramanathan, Sundra ; Reynolds, John ; Ong, Doen Ming ; Tiong, Ing S. ; Wall, Meaghan ; Murray, Michael ; Rawling, Tristan ; Leadbetter, Joanna ; Rowley, Leesa ; Latimer, Maya ; Yuen, Sam ; Ting, Stephen B. ; Fong, Chun Y. ; Morris, Kirk ; Bajel, Ashish ; Seymour, John F. ; Levis, Mark J. ; Wei, Andrew H.

United States: Elsevier Inc

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A Phase IB/II Study of Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia (ALL) and B-Cell Non-Hodgkin Lymphoma (NHL) As Post-Allogeneic Blood or Marrow Transplant (alloBMT) Remission Maintenance

Webster, Jonathan Allen ; Jones, Richard J. ; Blackford, Amanda ; Shedeck, Audra ; Ambinder, Richard F. ; Swinnen, Lode J. ; Wagner-Johnston, Nina ; Fuchs, Ephraim Joseph ; Bolanos-Meade, Javier ; Imus, Philip ; Bonifant, Challice L. ; Symons, Heather Jill ; Jain, Tania ; Prince, Gabrielle T. ; Levis, Mark J. ; Luznik, Leo ; Gojo, Ivana

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Quantum-First (Q-F): Clinical Bridging Study for FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD) Companion Diagnostic Development

Rohrbach, Jaime E ; Chang, Ken C N ; Karnoub, Maha ; Liu, Li ; Kamel, Yasser Mostafa ; Khambata-Ford, Shirin ; Rivera, Shawn ; Lameh, Jelveh ; Rudenko, Ekaterina ; Thornes, Jordan ; Todt, Sarah ; Gerhold, Jason ; Huang, Ying ; Miller, Jeffrey E ; Perl, Alexander ; Levis, Mark J. ; Ito, Kazumi

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Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) FLT3 -ITD+ AML Patients (pts)

Perl, Alexander ; Erba, Harry P. ; Montesinos, Pau ; Vrhovac, Radovan ; Patkowska, Elzbieta ; Kim, Heeje ; Zak, Pavel ; Wang, Po-Nan ; Rohrbach, Jaime E ; Chang, Ken C N ; Liu, Li ; Kamel, Yasser Mostafa ; Imadalou, Karima ; Lesegretain, Arnaud ; Cortes, Jorge ; Sekeres, Mikkael A. ; Dombret, Hervé ; Amadori, Sergio ; Wang, Jianxiang ; Schlenk, Richard F ; Levis, Mark J.

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Post-Hoc Analysis of Measurable Residual Disease from BMT-CTN 1506/Morpho: FLT3-ITD Variant Allele Frequency and Survival Are Highly Correlated

Levis, Mark J. ; Hamadani, Mehdi ; Logan, Brent R. ; Jones, Richard J. ; Singh, Anurag K. ; Litzow, Mark R. ; Wingard, John R. ; Papadopoulos, Esperanza B. ; Perl, Alexander ; Soiffer, Robert J. ; Ustun, Celalettin ; Ueda Oshima, Masumi ; Uy, Geoffrey L ; Waller, Edmund K. ; Vasu, Sumithira ; Solh, Melhem M. ; Mishra, Asmita ; Muffly, Lori S. ; Kim, Hee-Je ; Stelljes, Matthias ; Najima, Yuho ; Onozawa, Masahiro ; Thomson, Kirsty ; Nagler, Arnon ; Wei, Andrew H. ; Marcucci, Guido ; Hasabou, Nahla ; Rosales, Mathew ; Hill, Jason ; Gill, Stanley C. ; Nuthethi, Rishita ; King, Denise ; Wittsack, Heather ; Mendizabel, Adam ; Devine, Steven M. ; Horowitz, Mary M. ; Chen, Yi-Bin

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Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD) Positive Acute Myeloid Leukemia (AML)

Erba, Harry P. ; Dombret, Herve ; Perl, Alexander ; Mitov, Tsvetomir ; Liu, Li ; Kamel, Yasser Mostafa ; Imadalou, Karima ; Choi, Youngsook ; Levis, Mark J. ; Schlenk, Richard F

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Inhibition of NOTCH4 Sensitizes FLT3/ITD Acute Myeloid Leukemia Cells to FLT3 Tyrosine Kinase Inhibition

Zhu, Ruiqi ; Shirley, Courtney ; Chu, Haihua ; Li, Li ; Nguyen, Bao ; Seo, Jaesung ; Seale, Tessa ; Duffield, Amy ; Staudt, Louis M. ; Levis, Mark J. ; Hu, Yu ; Small, Donald

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A Phase I Trial of Activated Donor-Derived Marrow Infiltrating Lymphocytes to Treat Relapsed Hematologic Malignancies after Allogeneic Transplantation with Post-Transplantation Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis

Rimando, Joseph ; Mazziotta, Francesco ; Gareau, Alison ; Bettinotti, Maria ; Webster, Jonathan Allen ; Ali, Syed Abbas ; Imus, Philip ; Lemas, Mario Victor ; DeZern, Amy E. ; Levis, Mark J. ; Zahurak, Marianna ; Varadhan, Ravi ; Ambinder, Richard F. ; Huff, Carol ; Gojo, Ivana ; Jones, Richard J. ; Borrello, Ivan M. ; Luznik, Leo

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SHP2 Inhibition Overcomes Adaptive and Acquired Resistance to FLT3 TKI to Improve Efficacy Against FLT3/ITD AML

Seale, Tessa ; Li, Li ; Bruner, J. Kyle ; Nguyen, Bao ; Levis, Mark J. ; Pratilas, Christine ; Small, Donald

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Radiotherapy Consolidation Reduces Risk of Relapse in Diffuse Large B-Cell Lymphoma Patients with Bulky Disease in Complete Response after Frontline Immunochemotherapy: Results from a Retrospective Single Center Study

Benevolo Savelli, Corrado ; Novo, Mattia ; Vassallo, Francesco ; Evangelista, Andrea ; Bisio, Matteo ; Legato, Luca ; Peri, Veronica ; Clerico, Michele ; Levis, Mario ; Bartoncini, Sara ; Cavallin, Chiara ; Nicolosi, Maura ; Boccomini, Carola ; Orsucci, Lorella ; Cavallo, Federica ; Bruno, Benedetto ; Freilone, Roberto ; Ricardi, Umberto ; Botto, Barbara

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