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Visual Abstract - PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab: 10.1016/j.jacbts.2016.06.006Villard, Elise F. ; Thedrez, Aurélie ; Blankenstein, Jorg ; Mikaël Croyal ; Thi-Thu-Trang Tran ; Poirier, Bruno ; Jean-Christophe Le Bail ; Illiano, Stéphane ; Nobécourt, Estelle ; Krempf, Michel ; Blom, Dirk J. ; A. David Marais ; Janiak, Philip ; Muslin, Anthony J. ; Guillot, Etienne ; Lambert, GillesFigshare 2019Texto completo disponível |
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Figure 1: Lp(a) Uptake Is Not Modulated by LDLR Expression in Human FibroblastsVillard, Elise F. ; Thedrez, Aurélie ; Blankenstein, Jorg ; Mikaël Croyal ; Thi-Thu-Trang Tran ; Poirier, Bruno ; Jean-Christophe Le Bail ; Illiano, Stéphane ; Nobécourt, Estelle ; Krempf, Michel ; Blom, Dirk J. ; A. David Marais ; Janiak, Philip ; Muslin, Anthony J. ; Guillot, Etienne ; Lambert, GillesFigshare 2019Texto completo disponível |
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Figure 3: Inhibiting LDLR Expression With PCSK9 or LDLR Function With a Blocking Antibody Does Not Affect Lp(a) Uptake by Human Primary HepatocytesVillard, Elise F. ; Thedrez, Aurélie ; Blankenstein, Jorg ; Mikaël Croyal ; Thi-Thu-Trang Tran ; Poirier, Bruno ; Jean-Christophe Le Bail ; Illiano, Stéphane ; Nobécourt, Estelle ; Krempf, Michel ; Blom, Dirk J. ; A. David Marais ; Janiak, Philip ; Muslin, Anthony J. ; Guillot, Etienne ; Lambert, GillesFigshare 2019Texto completo disponível |
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Figure 4: PCSK9 Treatment Increases Apo(a) Secretion From Primary Human Hepatocytes: An Effect Blocked by AlirocumabVillard, Elise F. ; Thedrez, Aurélie ; Blankenstein, Jorg ; Mikaël Croyal ; Thi-Thu-Trang Tran ; Poirier, Bruno ; Jean-Christophe Le Bail ; Illiano, Stéphane ; Nobécourt, Estelle ; Krempf, Michel ; Blom, Dirk J. ; A. David Marais ; Janiak, Philip ; Muslin, Anthony J. ; Guillot, Etienne ; Lambert, GillesFigshare 2019Texto completo disponível |
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Figure 2: PCSK9 Reduces LDLR Expression in Human Primary Hepatocytes: An Effect Blocked by AlirocumabVillard, Elise F. ; Thedrez, Aurélie ; Blankenstein, Jorg ; Mikaël Croyal ; Thi-Thu-Trang Tran ; Poirier, Bruno ; Jean-Christophe Le Bail ; Illiano, Stéphane ; Nobécourt, Estelle ; Krempf, Michel ; Blom, Dirk J. ; A. David Marais ; Janiak, Philip ; Muslin, Anthony J. ; Guillot, Etienne ; Lambert, GillesFigshare 2019Texto completo disponível |