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Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
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Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

Nishimoto, Norihiro ; Terao, Kimio ; Mima, Toru ; Nakahara, Hideko ; Takagi, Nobuhiro ; Kakehi, Takahiro

Blood, 2008-11, Vol.112 (10), p.3959-3964 [Periódico revisado por pares]

United States: Elsevier Inc

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2
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease
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Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease

Fajgenbaum, David C ; Langan, Ruth-Anne ; Japp, Alberto Sada ; Partridge, Helen L ; Pierson, Sheila K ; Singh, Amrit ; Arenas, Daniel J ; Ruth, Jason R ; Nabel, Christopher S ; Stone, Katie ; Okumura, Mariko ; Schwarer, Anthony ; Jose, Fábio Freire ; Hamerschlak, Nelson ; Wertheim, Gerald B ; Jordan, Michael B ; Cohen, Adam D ; Krymskaya, Vera ; Rubenstein, Arthur ; Betts, Michael R ; Kambayashi, Taku ; van Rhee, Frits ; Uldrick, Thomas S

The Journal of clinical investigation, 2019-10, Vol.129 (10), p.4451-4463 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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3
Efficacy of the anti–IL-6 receptor antibody tocilizumab in neuromyelitis optica: A pilot study
Efficacy of the anti–IL-6 receptor antibody tocilizumab in neuromyelitis optica: A pilot study
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Efficacy of the anti–IL-6 receptor antibody tocilizumab in neuromyelitis optica: A pilot study

Araki, Manabu ; Matsuoka, Takako ; Miyamoto, Katsuichi ; Kusunoki, Susumu ; Okamoto, Tomoko ; Murata, Miho ; Miyake, Sachiko ; Aranami, Toshimasa ; Yamamura, Takashi

Neurology, 2014-04, Vol.82 (15), p.1302-1306 [Periódico revisado por pares]

Hagerstown, MD: American Academy of Neurology

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4
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis
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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis

Shankar-Hari, Manu ; Vale, Claire L ; Godolphin, Peter J ; Fisher, David ; Higgins, Julian P. T ; Spiga, Francesca ; Savovic, Jelena ; Tierney, Jayne ; Baron, Gabriel ; Benbenishty, Julie S ; Berry, Lindsay R ; Broman, Niklas ; Cavalcanti, Alexandre Biasi ; Colman, Roos ; De Buyser, Stefanie L ; Derde, Lennie P. G ; Domingo, Pere ; Omar, Sharifah Faridah ; Fernandez-Cruz, Ana ; Feuth, Thijs ; Garcia, Felipe ; Garcia-Vicuna, Rosario ; Gonzalez-Alvaro, Isidoro ; Gordon, Anthony C ; Haynes, Richard ; Hermine, Olivier ; Horby, Peter W ; Horick, Nora K ; Kumar, Kuldeep ; Lambrecht, Bart N ; Landray, Martin J ; Leal, Lorna ; Lederer, David J ; Lorenzi, Elizabeth ; Mariette, Xavier ; Merchante, Nicolas ; Misnan, Nor Arisah ; Mohan, Shalini V ; Nivens, Michael C ; Oksi, Jarmo ; Perez-Molina, Jose A ; Pizov, Reuven ; Porcher, Raphael ; Postma, Simone ; Rajasuriar, Reena ; Ramanan, Athimalaipet V ; Ravaud, Philippe ; Reid, Pankti D ; Rutgers, Abraham ; Sancho-Lopez, Aranzazu ; Seto, Todd B ; Sivapalasingam, Sumathi ; Soin, Arvinder Singh ; Staplin, Natalie ; Stone, John H ; Strohbehn, Garth W ; Sunden-Cullberg, Jonas ; Torre-Cisneros, Julian ; Tsai, Larry W ; van Hoogstraten, Hubert ; van Meerten, Tom ; Veiga, Viviane Cordeiro ; Westerweel, Peter E ; Murthy, Srinivas ; Diaz, Janet V ; Marshall, John C ; Sterne, Jonathan A. C

JAMA : the journal of the American Medical Association, 2021-08, Vol.326 (6), p.499-518 [Periódico revisado por pares]

United States: American Medical Association

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5
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent
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Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Mazzoni, Alessio ; Salvati, Lorenzo ; Maggi, Laura ; Capone, Manuela ; Vanni, Anna ; Spinicci, Michele ; Mencarini, Jessica ; Caporale, Roberto ; Peruzzi, Benedetta ; Antonelli, Alberto ; Trotta, Michele ; Zammarchi, Lorenzo ; Ciani, Luca ; Gori, Leonardo ; Lazzeri, Chiara ; Matucci, Andrea ; Vultaggio, Alessandra ; Rossi, Oliviero ; Almerigogna, Fabio ; Parronchi, Paola ; Fontanari, Paolo ; Lavorini, Federico ; Peris, Adriano ; Rossolini, Gian Maria ; Bartoloni, Alessandro ; Romagnani, Sergio ; Liotta, Francesco ; Annunziato, Francesco ; Cosmi, Lorenzo

The Journal of clinical investigation, 2020-09, Vol.130 (9), p.4694-4703 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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6
Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats
Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats
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Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats

Jain, Sushil K ; Rains, Justin ; Croad, Jennifer ; Larson, Bryon ; Jones, Kimberly

Antioxidants & redox signaling, 2009-02, Vol.11 (2), p.241-249 [Periódico revisado por pares]

United States: Mary Ann Liebert, Inc

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7
A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection
A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection
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A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection

Doberer, Konstantin ; Duerr, Michael ; Halloran, Philip F ; Eskandary, Farsad ; Budde, Klemens ; Regele, Heinz ; Reeve, Jeff ; Borski, Anita ; Kozakowski, Nicolas ; Reindl-Schwaighofer, Roman ; Waiser, Johannes ; Lachmann, Nils ; Schranz, Sabine ; Firbas, Christa ; Mühlbacher, Jakob ; Gelbenegger, Georg ; Perkmann, Thomas ; Wahrmann, Markus ; Kainz, Alexander ; Ristl, Robin ; Halleck, Fabian ; Bond, Gregor ; Chong, Edward ; Jilma, Bernd ; Böhmig, Georg A

Journal of the American Society of Nephrology, 2021-03, Vol.32 (3), p.708-722 [Periódico revisado por pares]

United States: American Society of Nephrology

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8
Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis
Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis
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Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis

Xiao, Yong-Tao ; Yan, Wei-Hui ; Cao, Yi ; Yan, Jun-Kai ; Cai, Wei

Cytokine (Philadelphia, Pa.), 2016-07, Vol.83, p.189-192 [Periódico revisado por pares]

England: Elsevier Ltd

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9
Origin and Function of Stress-Induced IL-6 in Murine Models
Origin and Function of Stress-Induced IL-6 in Murine Models
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Origin and Function of Stress-Induced IL-6 in Murine Models

Qing, Hua ; Desrouleaux, Reina ; Israni-Winger, Kavita ; Mineur, Yann S. ; Fogelman, Nia ; Zhang, Cuiling ; Rashed, Saleh ; Palm, Noah W. ; Sinha, Rajita ; Picciotto, Marina R. ; Perry, Rachel J. ; Wang, Andrew

Cell, 2020-07, Vol.182 (2), p.372-387.e14 [Periódico revisado por pares]

United States: Elsevier Inc

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10
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
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IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

Ridker, Paul M ; Devalaraja, Matt ; Baeres, Florian M M ; Engelmann, Mads D M ; Hovingh, G Kees ; Ivkovic, Milana ; Lo, Larry ; Kling, Douglas ; Pergola, Pablo ; Raj, Dominic ; Libby, Peter ; Davidson, Michael

The Lancet (British edition), 2021-05, Vol.397 (10289), p.2060-2069 [Periódico revisado por pares]

England: Elsevier Ltd

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