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Cardiovascular correlates of sleep apnea phenotypes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Wu, Benson ; Tarraf, Wassim ; Wallace, Douglas M ; Stickel, Ariana M ; Schneiderman, Neil ; Redline, Susan ; Patel, Sanjay R ; Gallo, Linda C ; Mossavar-Rahmani, Yasmin ; Daviglus, Martha L ; Zee, Phyllis C ; Talavera, Gregory A ; Sotres-Alvarez, Daniela ; González, Hector M ; Ramos, Alberto Iannella, Giannicola

PloS one, 2022-04, Vol.17 (4), p.e0265151-e0265151 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Cardiovascular correlates of sleep apnea phenotypes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Autor: Wu, Benson ; Tarraf, Wassim ; Wallace, Douglas M ; Stickel, Ariana M ; Schneiderman, Neil ; Redline, Susan ; Patel, Sanjay R ; Gallo, Linda C ; Mossavar-Rahmani, Yasmin ; Daviglus, Martha L ; Zee, Phyllis C ; Talavera, Gregory A ; Sotres-Alvarez, Daniela ; González, Hector M ; Ramos, Alberto
Iannella, Giannicola
Assuntos: Adults ; Aged ; Alzheimer's disease ; Alzheimers disease ; Apnea ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular system ; Clinical trials ; Complications ; Congestive heart failure ; Coronary artery disease ; Diabetes ; Diabetes mellitus ; Disease prevention ; Empirical analysis ; Female ; Genetic aspects ; Health aspects ; Health risks ; Heart diseases ; Hispanic Americans ; Hispanic or Latino ; Humans ; Hypertension ; Insomnia ; Medicine ; Medicine and Health Sciences ; Middle age ; Middle Aged ; Neurology ; Neurosciences ; Older people ; Phenotype ; Phenotypes ; Physiological aspects ; Public health ; Risk factors ; Self Report ; Signs and symptoms ; Sleep and wakefulness ; Sleep apnea ; Sleep apnea syndromes ; Sleep Apnea, Obstructive ; Sleep disorders ; Sleep Initiation and Maintenance Disorders ; Sleepiness ; Sociodemographics ; Stroke ; Supervision
É parte de: PloS one, 2022-04, Vol.17 (4), p.e0265151-e0265151
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
Descrição: Identifying Obstructive Sleep Apnea (OSA) phenotypes among middle-aged and older Hispanics/Latinos can facilitate personalized care, better inform treatment decisions, and could lead to improved clinical outcomes. We focused on middle-aged and older adults (ages ≥45-74 years at baseline) with an apnea-hypopnea index (AHI) ≥5 from the HCHS/SOL (2008-2011) (unweighted n = 3,545). We used latent class analyses (LCA) to identify empirical and clinically meaningful OSA phenotypes. Sleep variables included AHI, percent sleep time SpO2<90%, Epworth Sleepiness Scale (ESS), Women's Health Initiative Insomnia Rating Scale (WHIIRS) score, self-reported average sleep duration, restless legs symptoms, napping frequency, and self-reported sleep quality. We used survey logistic and Poisson regression to test the associations between our OSA phenotypes and prevalent and incident cardiovascular measures (cardiovascular disease, heart failure, Stroke/TIA, hypertension, diabetes, and the Framingham Cardiovascular Risk Score). Average AHI, ESS, WHIIRS, and sleep duration were 18.1±19.5, 6.3±6.1, 7.4±6.6, and 7.8±1.7 hours, respectively, and 2.9% had zero percent time SpO2 <90%. We identified a three-class solution that clustered individuals into (1) insomnia OSA (44.3%), (2) asymptomatic mild OSA, (36.2%) and (3) symptomatic OSA (19.5%). Elevated WHIIRS and AHI scores primarily drove classification into groups one and three, respectively. In covariate adjusted models, OSA phenotypes were differentially associated with prevalence (baseline and seven years later) and incidence of cardiovascular measures. OSA subtypes in diverse U.S. Hispanic/Latino adults have different cardiovascular complications. More targeted research, that takes these variations into account, could help ameliorate Hispanic/Latino sleep and cardiovascular health disparities.
Editor: United States: Public Library of Science
Idioma: Inglês

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Cardiovascular correlates of sleep apnea phenotypes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

United States: Public Library of Science

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