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Interaction between Tobacco and Alcohol Consumption and the Risk of Cancers of the Upper Aero-Digestive Tract in Brazil

Schlecht, Nicolas F. ; Franco, Eduardo L. ; Pintos, Javier ; Negassa, Abdissa ; Kowalski, Luiz P. ; Oliveira, Benedito V. ; Curado, and Maria P.

American journal of epidemiology, 1999-12, Vol.150 (11), p.1129-1137 [Periódico revisado por pares]

Cary, NC: Oxford University Press

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Título:
Interaction between Tobacco and Alcohol Consumption and the Risk of Cancers of the Upper Aero-Digestive Tract in Brazil
Autor: Schlecht, Nicolas F. ; Franco, Eduardo L. ; Pintos, Javier ; Negassa, Abdissa ; Kowalski, Luiz P. ; Oliveira, Benedito V. ; Curado, and Maria P.
Assuntos: alcohol drinking ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Brazil ; Brazil - epidemiology ; Case-Control Studies ; Confidence Intervals ; Data Interpretation, Statistical ; epidemiologic methods ; Female ; Head and Neck Neoplasms - epidemiology ; hedd and neck neoplasms ; Humans ; larnx ; Laryngeal Neoplasms - epidemiology ; Male ; Medical sciences ; Middle Aged ; mouth ; Mouth Neoplasms - epidemiology ; Odds Ratio ; Otorhinolaryngology. Stomatology ; Pharyngeal Neoplasms - epidemiology ; pharynk ; Risk Factors ; smoking ; Smoking - adverse effects ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
É parte de: American journal of epidemiology, 1999-12, Vol.150 (11), p.1129-1137
Notas: ark:/67375/HXZ-5HKTLSDX-N
ArticleID:150.11.1129
Reprint requests to Dr. Eduardo L. Franco, Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, Canada H2W 1 S6.
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Descrição: The authors investigated the joint effects of tobacco and alcohol consumption on the risk of squamous cell carcinomas of the upper aero-digestive tract (UADT) using data from a hospital-based case-control study conducted in southern Brazil, 1986-1989. A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1,578 non-cancer controls matched on age, sex, hospital catchment area, and period of admission were interviewed about their smoking and drinking habits and other characteristics. Using logistic regression, evidence was found for interaction between the cumulative exposures for smoking and alcohol on UADT cancer risk. The joint effects for pharyngeal cancers exceeded the levels expected under a multiplicative model for moderate smokers (p = 0.007). There was little statistical evidence, however, for interaction on cancers of the mouth (p = 0.28) or larynx (p = 0.95). Among never smokers, heavy drinkers had 9.2 times (95% confidence interval 1.7, 48.5) greater risk of cancers of mouth, pharynx, and supraglottis than never drinkers, with a dose-response trend (p = 0.013) with cumulative consumption. The authors conclude that the interaction occurring in the pharynx between smoking and alcohol on UADT cancers is not uniform, with varying effects depending on the level of smoking exposure. Alcohol may act as both a promoter for tobacco and as an independent risk factor. Am J Epidemiol 1999; 150:1129-37.
Editor: Cary, NC: Oxford University Press
Idioma: Inglês

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Interaction between Tobacco and Alcohol Consumption and the Risk of Cancers of the Upper Aero-Digestive Tract in Brazil

Schlecht, Nicolas F. ; Franco, Eduardo L. ; Pintos, Javier ; Negassa, Abdissa ; Kowalski, Luiz P. ; Oliveira, Benedito V. ; Curado, and Maria P.

Cary, NC: Oxford University Press

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