skip to main content
Idioma:
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

Sohn, Mira ; Korzeniowski, Marek ; Zewe, James P. ; Wills, Rachel C. ; Hammond, Gerald R.V. ; Humpolickova, Jana ; Vrzal, Lukas ; Chalupska, Dominika ; Veverka, Vaclav ; Fairn, Gregory D. ; Boura, Evzen ; Balla, Tamas

The Journal of cell biology, 2018-05, Vol.217 (5), p.1797-1813 [Periódico revisado por pares]

Rockefeller University Press

Texto completo disponível

Citações Citado por
  • Título:
    PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites
  • Autor: Sohn, Mira ; Korzeniowski, Marek ; Zewe, James P. ; Wills, Rachel C. ; Hammond, Gerald R.V. ; Humpolickova, Jana ; Vrzal, Lukas ; Chalupska, Dominika ; Veverka, Vaclav ; Fairn, Gregory D. ; Boura, Evzen ; Balla, Tamas
  • É parte de: The Journal of cell biology, 2018-05, Vol.217 (5), p.1797-1813
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P2 levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum (ER)–resident ORP5 and ORP8 is regulated by both PM PI4P and PI(4,5)P2. Dynamic control of ORP5/8 recruitment to the PM occurs through interactions with the N-terminal Pleckstrin homology domains and adjacent basic residues of ORP5/8 with both PI4P and PI(4,5)P2. Although ORP5 activity requires normal levels of these inositides, ORP8 is called on only when PI(4,5)P2 levels are increased. Regulation of the ORP5/8 attachment to the PM by both phosphoinositides provides a powerful means to determine the relative flux of PI4P toward the ER for PS transport and Sac1-mediated dephosphorylation and PIP 5-kinase–mediated conversion to PI(4,5)P2. Using this rheostat, cells can maintain PI(4,5)P2 levels by adjusting the availability of PI4P in the PM.
  • Editor: Rockefeller University Press
  • Idioma: Inglês
Voltar para lista de resultados
Resultado  1 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.