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"I just wanted more": Hereditary cancer syndromes patients' perspectives on the utility of circulating tumour DNA testing for cancer screening

Adi-Wauran, Ella ; Clausen, Marc ; Shickh, Salma ; Gagliardi, Anna R ; Denburg, Avram ; Oldfield, Leslie E ; Sam, Jordan ; Reble, Emma ; Krishnapillai, Suvetha ; Regier, Dean A ; Baxter, Nancy N ; Dawson, Lesa ; Penney, Lynette S ; Foulkes, William ; Basik, Mark ; Sun, Sophie ; Schrader, Kasmintan A ; Karsan, Aly ; Pollett, Aaron ; Pugh, Trevor J ; Kim, Raymond H ; Bombard, Yvonne

European journal of human genetics : EJHG, 2024-02, Vol.32 (2), p.176-181 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
"I just wanted more": Hereditary cancer syndromes patients' perspectives on the utility of circulating tumour DNA testing for cancer screening
Autor: Adi-Wauran, Ella ; Clausen, Marc ; Shickh, Salma ; Gagliardi, Anna R ; Denburg, Avram ; Oldfield, Leslie E ; Sam, Jordan ; Reble, Emma ; Krishnapillai, Suvetha ; Regier, Dean A ; Baxter, Nancy N ; Dawson, Lesa ; Penney, Lynette S ; Foulkes, William ; Basik, Mark ; Sun, Sophie ; Schrader, Kasmintan A ; Karsan, Aly ; Pollett, Aaron ; Pugh, Trevor J ; Kim, Raymond H ; Bombard, Yvonne
Assuntos: Adult ; Canada ; Cancer ; Cancer screening ; Circulating Tumor DNA - genetics ; Deoxyribonucleic acid ; DNA ; Early Detection of Cancer ; Female ; Humans ; Medical screening ; Neoplastic Syndromes, Hereditary ; Qualitative Research ; Tumors ; Young Adult
É parte de: European journal of human genetics : EJHG, 2024-02, Vol.32 (2), p.176-181
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Hereditary cancer syndromes (HCS) predispose individuals to a higher risk of developing multiple cancers. However, current screening strategies have limited ability to screen for all cancer risks. Circulating tumour DNA (ctDNA) detects DNA fragments shed by tumour cells in the bloodstream and can potentially detect cancers early. This study aimed to explore patients' perspectives on ctDNA's utility to help inform its clinical adoption and implementation. We conducted a qualitative interpretive description study using semi-structured phone interviews. Participants were purposively sampled adult HCS patients recruited from a Canadian HCS research consortium. Thirty HCS patients were interviewed (n = 19 women, age range 20s-70s, n = 25 were white). Participants were highly concerned about developing cancers, particularly those without reliable screening options for early detection. They "just wanted more" than their current screening strategies. Participants were enthusiastic about ctDNA's potential to be comprehensive (detect multiple cancers), predictive (detect cancers early) and tailored (lead to personalized clinical management). Participants also acknowledged ctDNA's potential limitations, including false positives/negatives risks and experiencing additional anxiety. However, they saw ctDNA's potential benefits outweighing its limitations. In conclusion, participants' belief in ctDNA's potential to improve their care overshadowed its limitations, indicating patients' support for using ctDNA in HCS care.
Editor: England: Nature Publishing Group
Idioma: Inglês

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"I just wanted more": Hereditary cancer syndromes patients' perspectives on the utility of circulating tumour DNA testing for cancer screening

England: Nature Publishing Group

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