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In vivo and continuous measurement of bisulfide in the hippocampus of rat's brain by an on-line integrated microdialysis/droplet-based microfluidic system

Gu, Feidan ; Zhou, Xiaoyu ; Zhu, Xiaocui ; Zhao, Meiping ; Hao, Jie ; Yu, Ping ; Mao, Lanqun

Analyst (London), 2015-06, Vol.14 (11), p.3814-3819 [Periódico revisado por pares]

England

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Título:
In vivo and continuous measurement of bisulfide in the hippocampus of rat's brain by an on-line integrated microdialysis/droplet-based microfluidic system
Autor: Gu, Feidan ; Zhou, Xiaoyu ; Zhu, Xiaocui ; Zhao, Meiping ; Hao, Jie ; Yu, Ping ; Mao, Lanqun
Assuntos: Animals ; Biology ; Brain ; Dynamical systems ; Dynamics ; Fluorescein - chemistry ; Fluorescent Dyes - chemistry ; Glutathione - chemistry ; Gold - chemistry ; Hippocampus ; Hippocampus - metabolism ; Isothiocyanates - chemistry ; Lab-On-A-Chip Devices ; Metal Nanoparticles - chemistry ; Microdialysis - methods ; Microfluidics ; Monitoring ; On-line systems ; Online Systems ; Rats ; Sulfides - chemistry ; Sulfides - metabolism ; Systems Integration ; Wakefulness
É parte de: Analyst (London), 2015-06, Vol.14 (11), p.3814-3819
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: An on-line and continuous approach was demonstrated for in vivo measurement of bisulfide in rat's brain. A modified droplet-based microfluidic system was constructed, which allowed on-line qualification of the fluorescence responses of the gold nanoparticle-glutathione-fluorescein isothiocyanate probe to the variation of bisulfide in the presence of the cerebral microdialysate background. The on-line method achieved a dynamic working range from 5.0 μM to 40 μM and a detection limit of 2.5 μM. The in vivo bisulfide concentration in the hippocampus of rat's brain was measured under different physiological conditions. The on-line method may facilitate the study of H 2 S biology by providing a previously unattainable continuous record of H 2 S variation in living animals. It also provides a practical platform for in vivo and continuous monitoring of other important species in cerebral systems. An on-line and continuous approach was demonstrated for in vivo measurement of bisulfide in rat's brain.
Editor: England
Idioma: Inglês

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In vivo and continuous measurement of bisulfide in the hippocampus of rat's brain by an on-line integrated microdialysis/droplet-based microfluidic system

Gu, Feidan ; Zhou, Xiaoyu ; Zhu, Xiaocui ; Zhao, Meiping ; Hao, Jie ; Yu, Ping ; Mao, Lanqun

England

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