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Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease

Marx, R.E ; Tursun, R

International journal of oral and maxillofacial surgery, 2012-03, Vol.41 (3), p.283-289 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease
Autor: Marx, R.E ; Tursun, R
Assuntos: Bacterial arthritis and osteitis ; Bacterial diseases ; Biological and medical sciences ; Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology ; bisphosphonates ; Bone Density Conservation Agents - adverse effects ; Bone Marrow - blood supply ; Bone Marrow - drug effects ; Bone Marrow - pathology ; Bone Marrow - radiation effects ; Bones, joints and connective tissue. Antiinflammatory agents ; Collagen ; Dentistry ; Diphosphonates - adverse effects ; Haversian System - pathology ; Human bacterial diseases ; Humans ; Infectious diseases ; Jaw Diseases - etiology ; Jaw Diseases - pathology ; Medical sciences ; Microvessels - pathology ; Microvessels - radiation effects ; Necrosis ; Osteoblasts - pathology ; Osteoclasts - drug effects ; Osteoclasts - pathology ; Osteocytes - pathology ; osteomyelitis ; Osteomyelitis - etiology ; Osteomyelitis - microbiology ; Osteomyelitis - pathology ; osteonecrosis ; osteoradionecrosis ; Osteoradionecrosis - etiology ; Osteoradionecrosis - pathology ; Otorhinolaryngology. Stomatology ; Periosteum - pathology ; Periosteum - radiation effects ; Pharmacology. Drug treatments ; Single-Blind Method ; Suppuration ; Surgery ; Thrombosis - pathology
É parte de: International journal of oral and maxillofacial surgery, 2012-03, Vol.41 (3), p.283-289
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Statistically, significant numbers of central bone specimens of suppurative osteomyelitis of the jaws (SOJ), bisphosphonate induced osteonecrosis of the jaws (BIONJ), and osteoradionecrosis of the jaws (ORNJ) were compared. All three evidenced the common finding of necrotic bone with empty osteocytic lacunae, Haversian and Volkmann canals, but each showed a distinctive histopathologic pattern indicating a different disease mechanism and treatment options. Suppurative osteomyelitis was characterized by intense marrow inflammation and marrow vessel thrombosis with retention of viable osteoclasts and periosteum. Bisphosphonate induced osteonecrosis was characterized by an empty marrow space with empty Howship's lacunae and an absence of osteoclasts but viable periosteum. Osteoradionecrosis was characterized by a collagenous hypocellular, hypovascular marrow space and nonviable periosteum. Histologic evidence in SOJ indicates a microorganism provoked intense inflammation and marrow vascular thrombosis creating an environment conducive to continual bacterial proliferation. BIONJ is seen as a non-inflammatory drug toxicity to bone by osteoclastic death leading to over suppression of bone renewal, and ORN as another non-inflammatory condition caused by a high linear energy transfer that impairs or kills numerous cell types in the field of radiation including periosteum, bone, and all soft tissue.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease

Marx, R.E ; Tursun, R

Kidlington: Elsevier Ltd

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