Idioma:

Minimal factor XIII activity level to prevent major spontaneous bleeds

Menegatti, M. ; Palla, R. ; Boscarino, M. ; Bucciarelli, P. ; Muszbek, L. ; Katona, E. ; Makris, M. ; Peyvandi, F. ; Halimeh, S. ; Lachmann, B. ; Bidlingmaier, C. ; Platokouki, H. ; Pergantou, H. ; Siboni, S. M. ; Schutgens, R. E. G. ; Borhany, M. ; Fatima, N. ; Mikovic, D. ; Saracevic, M. ; Moerloose, P. ; Casini, A. ; Ozdemir, N. ; Ay, Y. ; Mumford, A. ; Harvey, A. ; Payne, J. ; Shapiro, A. D. ; Williamson, A. ; Chapin, J. ; Hsu, F.

Journal of thrombosis and haemostasis, 2017-09, Vol.15 (9), p.1728-1736 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Minimal factor XIII activity level to prevent major spontaneous bleeds
Autor: Menegatti, M. ; Palla, R. ; Boscarino, M. ; Bucciarelli, P. ; Muszbek, L. ; Katona, E. ; Makris, M. ; Peyvandi, F. ; Halimeh, S. ; Lachmann, B. ; Bidlingmaier, C. ; Platokouki, H. ; Pergantou, H. ; Siboni, S. M. ; Schutgens, R. E. G. ; Borhany, M. ; Fatima, N. ; Mikovic, D. ; Saracevic, M. ; Moerloose, P. ; Casini, A. ; Ozdemir, N. ; Ay, Y. ; Mumford, A. ; Harvey, A. ; Payne, J. ; Shapiro, A. D. ; Williamson, A. ; Chapin, J. ; Hsu, F.
Assuntos: Adolescent ; Adult ; Age of Onset ; Anticoagulants - therapeutic use ; Area Under Curve ; Biomarkers - blood ; Bleeding ; Blood Coagulation - drug effects ; Blood Coagulation Tests ; Central nervous system ; Clinical Decision-Making ; Coagulation factors ; Cross-Sectional Studies ; Data processing ; Databases, Factual ; Europe ; factor XIII ; Factor XIII - analysis ; Factor XIII - therapeutic use ; factor XIII deficiency ; Factor XIII Deficiency - blood ; Factor XIII Deficiency - complications ; Factor XIII Deficiency - diagnosis ; Factor XIII Deficiency - drug therapy ; Female ; Gastrointestinal tract ; hemorrhage ; Hemorrhage - blood ; Hemorrhage - etiology ; Hemorrhage - prevention & control ; Humans ; Male ; Pakistan ; Phenotype ; Predictive Value of Tests ; Prophylaxis ; Prospective Studies ; Retrospective Studies ; ROC Curve ; Severity of Illness Index ; United States ; Young Adult
É parte de: Journal of thrombosis and haemostasis, 2017-09, Vol.15 (9), p.1728-1736
Descrição: Essentials A strong association between bleeding severity and FXIII activity level (FXIII:C) was shown. The range 5–30 IU dL−1 of FXIII:C was associated with a high variability of bleeding severity. The PROspective study confirmed the association between FXIII:C activity and bleeding severity. A FXIII:C of 15 IU dL−1 is a proposed target to start prophylaxis for prevention of major bleeding. Summary Background Congenital factor XIII (FXIII) deficiency is a rare bleeding disorder associated with significant bleeding manifestations. The European Network of Rare Bleeding Disorders (EN‐RBD) study, performed from 2007 to 2010, showed a strong association between bleeding severity and FXIII activity in plasma of patients with FXIII deficiency. Among these patients, variable levels of FXIII activity, from undetectable to 30%, were associated with a wide range of bleeding severity. Objectives and patients The present cross‐sectional study, in the frame of the PRO‐RBDD project, a prospective cohort study, analyzed data of 64 patients with FXIII deficiency and different types of clinical and laboratory severity. Results The results of this analysis confirmed that FXIII coagulant activity in plasma is well associated with clinical severity of patients. In addition, 15 IU dL−1 of FXIII activity was identified to be the level under which the probability of spontaneous major bleeding sharply increases (from 50% for levels of 15 IU dL−1 to more than 90% for levels of 5 IU dL−1 or lower). Conclusion The PRO‐RBDD study suggests a FXIII coagulant activity level of 15 IU dL−1 as a target to start prophylaxis in order to prevent major bleedings, such as central nervous system or gastrointestinal tract hemorrhages.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Minimal factor XIII activity level to prevent major spontaneous bleeds

England: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.