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Evaluation of purine-nucleoside degrading ability and in vivo uric acid lowering of Streptococcus thermophilus IDCC 2201, a novel antiuricemia strain

Kim, Dayoung ; Moon, Jin Seok ; Kim, Ji Eun ; Jang, Ye-Ji ; Choi, Han Sol ; Oh, Ikhoon Al Kassaa, Imad

PloS one, 2024-02, Vol.19 (2), p.e0293378-e0293378 [Periódico revisado por pares]

United States: Public Library of Science

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  • Título:
    Evaluation of purine-nucleoside degrading ability and in vivo uric acid lowering of Streptococcus thermophilus IDCC 2201, a novel antiuricemia strain
  • Autor: Kim, Dayoung ; Moon, Jin Seok ; Kim, Ji Eun ; Jang, Ye-Ji ; Choi, Han Sol ; Oh, Ikhoon
  • Al Kassaa, Imad
  • Assuntos: Analysis ; Animals ; Biology and Life Sciences ; Fatty acids ; Health aspects ; High performance liquid chromatography ; Humans ; Hyperuricemia - metabolism ; Instrument industry ; Medicine and Health Sciences ; Microbiota (Symbiotic organisms) ; Nucleosides ; People and places ; Physical Sciences ; Physiological aspects ; Purine Nucleosides - metabolism ; Rats ; Rats, Sprague-Dawley ; Streptococcus ; Streptococcus thermophilus ; Uric Acid ; Xanthine
  • É parte de: PloS one, 2024-02, Vol.19 (2), p.e0293378-e0293378
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Competing Interests: The authors have declared that no competing interests exist.
  • Descrição: This study evaluated 15 lactic acid bacteria with a focus on their ability to degrade inosine and hypo-xanthine-which are the intermediates in purine metabolism-for the management of hyperuricemia and gout. After a preliminary screening based on HPLC, Lactiplantibacillus plantarum CR1 and Lactiplantibacillus pentosus GZ1 were found to have the highest nucleoside degrading rates, and they were therefore selected for further characterization. S. thermophilus IDCC 2201, which possessed the hpt gene encoding hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and exhibited purine degradation, was also selected for further characterization. These three selected strains were examined in terms of their probiotic effect on lowering serum uric acid in a Sprague-Dawley (SD) rat model of potassium oxonate (PO)-induced hyperuricemia. Among these three strains, the level of serum uric acid was most reduced by S. thermophilus IDCC 2201 (p < 0.05). Further, analysis of the microbiome showed that administration of S. thermophlilus IDCC 2201 led to a significant difference in gut microbiota composition compared to that in the group administered with PO-induced hyperuricemia. Moreover, intestinal short-chain fatty acids (SCFAs) were found to be significantly increased. Altogether, the results of this work indicate that S. thermophilus IDCC 2201 lowers uric acid levels by degrading purine-nucleosides and also restores intestinal flora and SCFAs, ultimately suggesting that S. thermophilus IDCC 2201 is a promising candidate for use as an adjuvant treatment in patients with hyperuricemia.
  • Editor: United States: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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