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Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus

Jiang, Wen-Gao ; Li, Su-Xia ; Zhou, Shuang-Jiang ; Sun, Yan ; Shi, Jie ; Lu, Lin

Brain research, 2011-07, Vol.1399, p.25-32 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus
Autor: Jiang, Wen-Gao ; Li, Su-Xia ; Zhou, Shuang-Jiang ; Sun, Yan ; Shi, Jie ; Lu, Lin
Assuntos: Adult and adolescent clinical studies ; Analysis of Variance ; animal models ; Animals ; Antidepressive Agents, Tricyclic - pharmacology ; Antidepressive Agents, Tricyclic - therapeutic use ; Biological and medical sciences ; Chronic Disease ; Chronic unpredictable stress ; circadian rhythm ; Circadian Rhythm - physiology ; clinical trials ; Depression ; Desipramine - pharmacology ; Desipramine - therapeutic use ; Disease Models, Animal ; Exploratory Behavior - drug effects ; Exploratory Behavior - physiology ; face ; Food Preferences - drug effects ; Food Preferences - physiology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; hypothalamus ; Male ; mammals ; Medical sciences ; Mood disorders ; Neurology ; Period 2 ; Period Circadian Proteins - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological - drug therapy ; Stress, Psychological - pathology ; Stress, Psychological - physiopathology ; Sucrose - administration & dosage ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - drug effects ; Suprachiasmatic Nucleus - metabolism ; Time Factors
É parte de: Brain research, 2011-07, Vol.1399, p.25-32
Notas: http://dx.doi.org/10.1016/j.brainres.2011.05.001
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Descrição: Abstract Many clinical studies have shown that circadian rhythm abnormalities are strongly associated with major depression. The master clock of the circadian system in mammals is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus, where Per1 and Per2 are essential core components of circadian rhythm oscillation. Chronic unpredictable stress (CUS) is a reliable animal model of depression with good face, predictive, and constructive validity. In the present study, we investigated the effects of CUS on the circadian expression of PER1 and PER2 in the SCN. We found that CUS led to depressive-like behavior and reduced the amplitude of PER2 oscillation in the SCN, which were blocked by 3 weeks of desipramine (DMI) treatment. 2 weeks after termination of CUS, the decreased peak of PER2 expression returned to control levels, whereas depressive-like behavior remained unchanged. Our findings suggest that the dampened amplitude of PER2 expression in the SCN may participate in the development of depressive-like behavior induced by CUS but is unlikely involved in the long-lasting effects of CUS on depressive-like behavior.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus

Jiang, Wen-Gao ; Li, Su-Xia ; Zhou, Shuang-Jiang ; Sun, Yan ; Shi, Jie ; Lu, Lin

Amsterdam: Elsevier B.V

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