Idioma:

Fumonisin and ochratoxin production in industrial Aspergillus niger strains

Frisvad, Jens C ; Larsen, Thomas O ; Thrane, Ulf ; Meijer, Martin ; Varga, Janos ; Samson, Robert A ; Nielsen, Kristian F McCluskey, Kevin

PloS one, 2011-08, Vol.6 (8), p.e23496 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Fumonisin and ochratoxin production in industrial Aspergillus niger strains
Autor: Frisvad, Jens C ; Larsen, Thomas O ; Thrane, Ulf ; Meijer, Martin ; Varga, Janos ; Samson, Robert A ; Nielsen, Kristian F
McCluskey, Kevin
Assuntos: Acid production ; Acids ; Agar ; Agriculture ; Alcohol ; Amino acids ; Animal feed ; Animal feeding and feeds ; Aspergillus ; Aspergillus foetidus ; Aspergillus niger ; Aspergillus niger - drug effects ; Aspergillus niger - metabolism ; Biodiversity ; Biology ; Biomass ; Biosynthesis ; Biotechnological microorganisms ; Biotechnology ; Carcinogens ; Citric acid ; Citric Acid - metabolism ; Culture media ; Culture Media - pharmacology ; Fermentation ; Food ; Food contamination ; Fumonisins ; Fumonisins - metabolism ; Fungi ; Fusarium ; Gene clusters ; Indoor environments ; Industrial applications ; Industrial Microbiology ; Industrial strains ; Metabolism ; Metabolites ; Microbial biotechnology ; Mycotoxins ; Ochratoxin A ; Ochratoxins - biosynthesis ; Random mutagenesis ; Soil contamination ; Species ; Species Specificity ; Toxins
É parte de: PloS one, 2011-08, Vol.6 (8), p.e23496
Notas: Conceived and designed the experiments: JCF KFN. Performed the experiments: JCF KFN MM. Analyzed the data: JCF KFN UT TOL MM RAS JV. Contributed reagents/materials/analysis tools: KFN MM. Wrote the paper: JCF KFN. Read and improved the draft paper: JCF KFN UT TOL RAS MM JV.
Descrição: Aspergillus niger is perhaps the most important fungus used in biotechnology, and is also one of the most commonly encountered fungi contaminating foods and feedstuffs, and occurring in soil and indoor environments. Many of its industrial applications have been given GRAS status (generally regarded as safe). However, A. niger has the potential to produce two groups of potentially carcinogenic mycotoxins: fumonisins and ochratoxins. In this study all available industrial and many non-industrial strains of A. niger (180 strains) as well as 228 strains from 17 related black Aspergillus species were examined for mycotoxin production. None of the related 17 species of black Aspergilli produced fumonisins. Fumonisins (B(2), B(4), and B(6)) were detected in 81% of A. niger, and ochratoxin A in 17%, while 10% of the strains produced both mycotoxins. Among the industrial strains the same ratios were 83%, 33% and 26% respectively. Some of the most frequently used strains in industry NRRL 337, 3112 and 3122 produced both toxins and several strains used for citric acid production were among the best producers of fumonisins in pure agar culture. Most strains used for other biotechnological processes also produced fumonisins. Strains optimized through random mutagenesis usually maintained their mycotoxin production capability. Toxigenic strains were also able to produce the toxins on media suggested for citric acid production with most of the toxins found in the biomass, thereby questioning the use of the remaining biomass as animal feed. In conclusion it is recommended to use strains of A. niger with inactive or inactivated gene clusters for fumonisins and ochratoxins, or to choose isolates for biotechnological uses in related non-toxigenic species such as A. tubingensis, A. brasiliensis, A vadensis or A. acidus, which neither produce fumonisins nor ochratoxins.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 14 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Fumonisin and ochratoxin production in industrial Aspergillus niger strains

Frisvad, Jens C ; Larsen, Thomas O ; Thrane, Ulf ; Meijer, Martin ; Varga, Janos ; Samson, Robert A ; Nielsen, Kristian F McCluskey, Kevin

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.