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Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study

Mohr, Nicholas M ; Plumb, Ian D ; Harland, Kari K ; Pilishvili, Tamara ; Fleming-Dutra, Katherine E ; Krishnadasan, Anusha ; Hoth, Karin F ; Saydah, Sharon H ; Mankoff, Zachary ; Haran, John P ; Briggs-Hagen, Melissa ; León, Eliezer Santos ; Talan, David A ; Smithline, Howard A ; Hou, Peter C ; Lee, Lilly C ; Lim, Stephen C ; Moran, Gregory J ; Steele, Mark T ; Beiser, David G ; Faine, Brett ; Nandi, Utsav ; Schrading, Walter A ; Chinnock, Brian ; Chipman, Anne ; Fuentes, Megan ; LoVecchio, Frank ; Clinansmith, Bradley ; Landers, Shannon ; Horcher, Alysia ; Wallace, Kelli ; Uribe, Lisandra ; Pathmarajah, Kavitha ; Poronsky, Kye E ; Hashimoto, Dean M ; Bahamon, Monica ; Romain, Michelle St ; Kean, Efrat ; Krebs, Elizabeth ; Stubbs, Amy ; Roy, Sara ; Volturo, Gregory ; Higgins, Amanda ; Galbraith, James ; Crosby, James C ; Mulrow, Mary ; Gonzalez, Eva ; Gierke, Ryan ; Farrar, Jennifer L ; Xing, Wei ; Chung, Yunmi ; Yousaf, Anna ; Okaro, Jennifer Onukwube ; Briggs-Hagen, Melissa ; Abedi, Glen R ; Nyanseor, Sankan ; Watts, Christopher K

BMJ open, 2023-02, Vol.13 (2), p.e063141-e063141 [Periódico revisado por pares]

England: British Medical Journal Publishing Group

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Título:
Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
Autor: Mohr, Nicholas M ; Plumb, Ian D ; Harland, Kari K ; Pilishvili, Tamara ; Fleming-Dutra, Katherine E ; Krishnadasan, Anusha ; Hoth, Karin F ; Saydah, Sharon H ; Mankoff, Zachary ; Haran, John P ; Briggs-Hagen, Melissa ; León, Eliezer Santos ; Talan, David A ; Smithline, Howard A ; Hou, Peter C ; Lee, Lilly C ; Lim, Stephen C ; Moran, Gregory J ; Steele, Mark T ; Beiser, David G ; Faine, Brett ; Nandi, Utsav ; Schrading, Walter A ; Chinnock, Brian ; Chipman, Anne ; Fuentes, Megan ; LoVecchio, Frank ; Clinansmith, Bradley ; Landers, Shannon ; Horcher, Alysia ; Wallace, Kelli ; Uribe, Lisandra ; Pathmarajah, Kavitha ; Poronsky, Kye E ; Hashimoto, Dean M ; Bahamon, Monica ; Romain, Michelle St ; Kean, Efrat ; Krebs, Elizabeth ; Stubbs, Amy ; Roy, Sara ; Volturo, Gregory ; Higgins, Amanda ; Galbraith, James ; Crosby, James C ; Mulrow, Mary ; Gonzalez, Eva ; Gierke, Ryan ; Farrar, Jennifer L ; Xing, Wei ; Chung, Yunmi ; Yousaf, Anna ; Okaro, Jennifer Onukwube ; Briggs-Hagen, Melissa ; Abedi, Glen R ; Nyanseor, Sankan ; Watts, Christopher K
Assuntos: Cohort analysis ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Data collection ; Delivery of Health Care ; Drug dosages ; EPIDEMIOLOGY ; Humans ; Infections ; Infectious diseases ; Medical records ; mRNA Vaccines ; Prospective Studies ; SARS-CoV-2 ; Sensitivity analysis ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination
É parte de: BMJ open, 2023-02, Vol.13 (2), p.e063141-e063141
Notas: Original research
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: ObjectivesAlthough COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work.DesignCohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset.SettingHealth systems in 12 US states.ParticipantsHCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset.ExposuresTwo doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine.Main outcome measuresPrevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work.ResultsAmong 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79).ConclusionsReceipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work.
Editor: England: British Medical Journal Publishing Group
Idioma: Inglês

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Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study

England: British Medical Journal Publishing Group

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