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Volumetric assessment of myocardial viability in rats using 3D double contrast enhanced T1 and T2-weighted MRI

Chapon, C ; Franconi, F ; Lemaire, L ; Marescaux, L ; Legras, P ; Denizot, B ; Le Jeune, J-J

Magma (New York, N.Y.), 2005-12, Vol.18 (6), p.302-308 [Periódico revisado por pares]

Germany: Springer Nature B.V

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Título:
Volumetric assessment of myocardial viability in rats using 3D double contrast enhanced T1 and T2-weighted MRI
Autor: Chapon, C ; Franconi, F ; Lemaire, L ; Marescaux, L ; Legras, P ; Denizot, B ; Le Jeune, J-J
Assuntos: Analysis of Variance ; Animals ; Bioengineering ; Contrast Media ; Heterocyclic Compounds ; Imaging ; Imaging, Three-Dimensional - methods ; Life Sciences ; Magnetic Resonance Imaging - methods ; Medication ; Myocardial Infarction - pathology ; Myocardial Infarction - therapy ; Nanotechnology ; Organometallic Compounds ; Particle Size ; Pharmaceutical sciences ; Rats
É parte de: Magma (New York, N.Y.), 2005-12, Vol.18 (6), p.302-308
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Volumetric evaluation of the myocardial viability post-infarction in rats using 3D in vivo MR imaging at 7 T using injection of an extracellular paramagnetic contrast agent and intravascular superparamagnetic iron oxide nanoparticles in the same imaging session. Five hours after induction of permanent myocardial infarction in rats (n=6), 3D in vivo T1- and T2-weighted MR Imaging was performed prior to and after Gd-DOTA injection (0.2 mmol/kg) and prior to and after nanoparticle injection (5 mg Fe/kg) to assess infarct size and myocardial viability. 3D MR Imaging using a successive contrast agent injection showed a difference of infarct size after Gd-DOTA injection on T1-weighted images compared to the one measured on T2-weighted images after Gd-DOTA and nanoparticle injection. The use of 3D T1- and T2-weighted MR Imaging using a double contrast agents protocol made possible the accurate characterization of myocardial infarction volume and allowed the detection of myocardial viability post-infarction in rats.
Editor: Germany: Springer Nature B.V
Idioma: Inglês

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Volumetric assessment of myocardial viability in rats using 3D double contrast enhanced T1 and T2-weighted MRI

Chapon, C ; Franconi, F ; Lemaire, L ; Marescaux, L ; Legras, P ; Denizot, B ; Le Jeune, J-J

Germany: Springer Nature B.V

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