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Association of CYP3A4 genotype with detection of Vy/Jbeta trans-rearrangements in the peripheral blood leukocytes of pediatric cancer patients undergoing chemotherapy for ALL

Luiz F. Lopes Fábio De S Piccoli; Valéria A Paixão; Maria do Rosário Dias de Oliveira Latorre; Andrew J. G Simpson; Otávia L Caballero

Leukemia Research Oxford v. 28, n. 12, p. 1281-1286, 2004

Oxford 2004

Localização: FSP - Faculdade de Saúde Pública    (HEP-12/2004 )(Acessar)

  • Título:
    Association of CYP3A4 genotype with detection of Vy/Jbeta trans-rearrangements in the peripheral blood leukocytes of pediatric cancer patients undergoing chemotherapy for ALL
  • Autor: Luiz F. Lopes
  • Fábio De S Piccoli; Valéria A Paixão; Maria do Rosário Dias de Oliveira Latorre; Andrew J. G Simpson; Otávia L Caballero
  • Assuntos: NEOPLASIAS; QUIMIOTERAPIA; FÁRMACOS (TOXICIDADE)
  • É parte de: Leukemia Research Oxford v. 28, n. 12, p. 1281-1286, 2004
  • Descrição: Cancer patients receiving chemotherapy are exposed to high dose of cytotoxic and genotoxic drugs which, in some cases, can lead to treatment related leukemia. Since this only occurs in a minority of patients, however, it is possible some individuals are predisposed due to genetic polymorphisms in genes for enzymes that mediate drug metabolism. To address this possibility we measured the genotoxicity of chemotherapeutic agents in patients receiving treatment for ALL by the frequency of the Vã/Jâ trans-rerrangement in their peripheral blood leukocytes and compared this with CYP3A4 gonotype. CYP3A4 is the most abundant of the cytochrome P450 (CVP) enzyme in the liver and intestine which cuntains a common -392A>G substitution in the promoter region (CYP3A4*1B allele). We found a significant increase in lhe frequency of rerrangements during chemoterapy onJy in patients homozygous for the wild type CYP3A4*1A allele. This provides a direct link between CYP3A4 genotype and susceptibility to drug genotoxicity thus strengthening the possibility that predisposition to treatment related leukemia may be measurable by simple genetic testing.(AU)
  • Editor: Oxford
  • Data de criação/publicação: 2004
  • Formato: p. 1281-1286.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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