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High‐risk human papillomavirus 16/18 associated with improved survival in sinonasal squamous cell carcinoma

Ramkumar, Shreya P. ; Simpson, Matthew C. ; Adjei Boakye, Eric ; Bukatko, Aleksandr R. ; Antisdel, Jastin L. ; Massa, Sean T. ; Osazuwa‐Peters, Nosayaba

Cancer, 2023-05, Vol.129 (9), p.1372-1383 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
High‐risk human papillomavirus 16/18 associated with improved survival in sinonasal squamous cell carcinoma
Autor: Ramkumar, Shreya P. ; Simpson, Matthew C. ; Adjei Boakye, Eric ; Bukatko, Aleksandr R. ; Antisdel, Jastin L. ; Massa, Sean T. ; Osazuwa‐Peters, Nosayaba
Assuntos: Cancer ; cancer survival ; Carcinoma, Squamous Cell - pathology ; Cell survival ; Head & neck cancer ; Health hazards ; Health risks ; high‐risk human papillomavirus ; Human papillomavirus ; human papillomavirus (HPV) ; Human papillomavirus 16 - genetics ; human papillomavirus 16/18 ; Human Papillomavirus Viruses ; Humans ; National Cancer Database (NCDB) ; Oncology ; Papillomavirus Infections ; Paranasal sinus ; Paranasal Sinus Neoplasms - pathology ; Retrospective Studies ; Risk ; sinonasal cancer ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - complications ; Statistical analysis ; Survival ; Tumors
É parte de: Cancer, 2023-05, Vol.129 (9), p.1372-1383
Notas: The last two authors contributed equally to this article as co‐senior author.
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Descrição: Background There has been conflicting evidence on the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The objective of this study was to assess whether the survival of patients with sinonasal cancer differs based on various HPV statuses, including HPV‐negative, positive for the high‐risk HPV‐16 and HPV‐18 (HPV16/18) subtypes, and positive for other high‐risk and low‐risk HPV subtypes. Methods In this retrospective cohort study, data from the National Cancer Database were extracted from the years 2010–2017 for patients who had primary sinonasal cancer (N = 12,009). The outcome of interest was overall survival based on HPV tumor status. Results Study included an analytic cohort of 1070 patients with sinonasal cancer who had confirmed HPV tumor status (732 [68.4%] HPV‐negative; 280 [26.2%] HPV16/18‐positive; 40 [3.7%] positive for other high‐risk HPV; and 18 [1.7%] positive for low‐risk HPV). HPV‐negative patients had the lowest all‐cause survival probability at 5 years postdiagnosis (0.50). After controlling for covariates, HPV16/18‐positive patients had a 37% lower mortality hazard than HPV‐negative patients (adjusted hazard ratio, 0.63; 95% confidence interval [CI], 0.48–0.82). Patients aged 64–72 years (crude prevalence ratio, 0.66; 95% CI, 0.51–0.86) and 73 years and older (crude prevalence ratio, 0.43; 95% CI, 0.31–0.59) presented with lower rates of HPV16/18‐positive sinonasal cancer than those aged 40–54 years. In addition, Hispanic patients had a 2.36 times higher prevalence of non‐HPV16/18 sinonasal cancer than non‐Hispanic White patients. Conclusions These data suggest that, for patients with sinonasal cancer, HPV16/18‐positive disease may confer a significant survival advantage compared with HPV‐negative disease. Other high‐risk and low‐risk HPV subtypes have survival rates similar to the rates for HPV‐negative disease. HPV status might be an important independent prognostic factor in sinonasal cancer that could be used in patient selection and clinical decisions. In this retrospective cohort study, patients who were positive for the human papillomavirus (HPV) 16/18 subtypes had a statistically significant lower hazard of mortality than HPV‐negative patients. HPV tumor status may be prognostic for sinonasal cancer and should be collected routinely in this patient population.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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High‐risk human papillomavirus 16/18 associated with improved survival in sinonasal squamous cell carcinoma

Ramkumar, Shreya P. ; Simpson, Matthew C. ; Adjei Boakye, Eric ; Bukatko, Aleksandr R. ; Antisdel, Jastin L. ; Massa, Sean T. ; Osazuwa‐Peters, Nosayaba

United States: Wiley Subscription Services, Inc

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