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Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD

Santos-Terra, Júlio ; Deckmann, Iohanna ; Schwingel, Gustavo Brum ; Paz, André Vinicius Contri ; Gama, Clarissa S. ; Bambini-Junior, Victorio ; Fontes-Dutra, Mellanie ; Gottfried, Carmem

Brain research, 2021-10, Vol.1768, p.147593-147593, Article 147593 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD
Autor: Santos-Terra, Júlio ; Deckmann, Iohanna ; Schwingel, Gustavo Brum ; Paz, André Vinicius Contri ; Gama, Clarissa S. ; Bambini-Junior, Victorio ; Fontes-Dutra, Mellanie ; Gottfried, Carmem
Assuntos: Animal model ; Animals ; Autism Spectrum Disorder ; Autism Spectrum Disorder - drug therapy ; Autism Spectrum Disorder - metabolism ; Behavior, Animal - drug effects ; Disease Models, Animal ; Female ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Interneuron ; Interneurons - drug effects ; Interneurons - metabolism ; Long-term alterations ; Male ; Neurons - metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects - physiopathology ; Rats ; Rats, Wistar ; Resveratrol ; Resveratrol - metabolism ; Resveratrol - pharmacology ; Social Behavior ; Stereotyped Behavior - drug effects ; Valproic Acid - pharmacology
É parte de: Brain research, 2021-10, Vol.1768, p.147593-147593, Article 147593
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: [Display omitted] •Resveratrol prevents hippocampal morphological alterations induced by valproic acid;•Resveratrol prevents alterations induced by valproic acid in interneurons.•Valproic acid impairs protein expression associated with cell signaling pathways;•Identification of long-term alterations may optimize the understanding of ASD. Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in both communication and social interaction, besides repetitive or stereotyped behavior. Although the etiology is unknown, environmental factors such as valproic acid (VPA) increase the risk of ASD onset. Resveratrol (RSV), a neuroprotective molecule, has been shown to counteract the effects of intrauterine exposure to VPA. We aimed to evaluate histological parameters related to hippocampal morphology and to the distribution of parvalbumin- (PV), calbindin- (CB), and somatostatin-positive (SOM) interneurons sub-populations, in addition to evaluate the total/phosphorylation levels of PTEN, AKT, GSK3β and total CK2 in the animal model of autism induced by VPA, as well as addressing the potential protective effect of RSV. On postnatal day 120, histological analysis showed a loss in total neurons in the dentate gyrus (DG) and decreased CB+ neurons in DG and CA1 in VPA animals, both prevented by RSV. In addition, PV+ neurons were diminished in CA1, CA2, and CA3, and SOM+ were interestingly increased in DG (prevented by RSV) and decreased in CA1 and CA2. A hippocampal lesion similar to sclerosis was also observed in the samples from the VPA group. Besides that, VPA reduced AKT and PTEN immunocontent, and VPA increased CK2 immunocontent. Thus, this work demonstrated long-term effects of prenatal exposure to ASD in different sub-populations of interneurons, structural damage of hippocampus, and also alteration in proteins associated with pivotal cell signaling pathways, highlighting the role of RSV as a tool for understanding the pathophysiology of ASD.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD

Santos-Terra, Júlio ; Deckmann, Iohanna ; Schwingel, Gustavo Brum ; Paz, André Vinicius Contri ; Gama, Clarissa S. ; Bambini-Junior, Victorio ; Fontes-Dutra, Mellanie ; Gottfried, Carmem

Netherlands: Elsevier B.V

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