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Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults

LANCHOTE, V. L ; BONATO, P. S ; CAMPOS, G. M ; RODRIGUES, I

Therapeutic drug monitoring, 1995-02, Vol.17 (1), p.47-52 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults
Autor: LANCHOTE, V. L ; BONATO, P. S ; CAMPOS, G. M ; RODRIGUES, I
Assuntos: Adolescent ; Adult ; Aging - metabolism ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - pharmacology ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Carbamazepine - analogs & derivatives ; Carbamazepine - blood ; Carbamazepine - pharmacokinetics ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Drug Interactions ; Epilepsy - blood ; Female ; Humans ; Infant ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments
É parte de: Therapeutic drug monitoring, 1995-02, Vol.17 (1), p.47-52
Descrição: Plasma carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) concentrations were measured in 160 epileptic patients in order to determine the effect of factors such as age, daily dosing schedule, formulation, and combination with other antiepileptic drugs on these concentrations in relation to the daily dose. The results showed that the CBZ plasma level/dose ratio was affected by all factors studied, whereas the CBZ-E plasma level/dose ratio was affected only by formulation and age. The ratio of CBZ-E to CBZ plasma levels (CBZ-E/CBZ) was affected by daily dosing schedule, age, and combination with other antiepileptic drugs. The present study demonstrated that many factors affect plasma CBZ/dose ratios, explaining the discrepancies observed in the literature.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults

LANCHOTE, V. L ; BONATO, P. S ; CAMPOS, G. M ; RODRIGUES, I

Hagerstown, MD: Lippincott Williams & Wilkins

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